Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOCS5
  • Mouse genes Socs5
  • Rat genes Socs5
  • Zfish genes socs5a,socs5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Socs5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Socs5	IPI	PR:Q01279	Mouse	PMID:15695332
Molecular Function	GO:0005515	protein binding	SOCS5	IPI	UniProtKB:Q15369	Human	PMID:15590694
Molecular Function	GO:0005515	protein binding	SOCS5	IPI	UniProtKB:Q15370	Human	PMID:15590694
Molecular Function	GO:0005515	protein binding	SOCS5	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	Socs5	IPI	UniProtKB:P16382	Mouse	MGI:MGI:3687909|PMID:12242343
Molecular Function	GO:0030971	receptor tyrosine kinase binding	SOCS5	IPI	UniProtKB:P00533	Human	PMID:15590694
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Socs5	IMP		Mouse	MGI:MGI:5659826|PMID:24255059
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Socs5	IDA		Mouse	MGI:MGI:3687909|PMID:12242343
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Socs5	IDA		Mouse	PMID:15695332
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	SOCS5	IDA		Human	PMID:15590694
Biological Process	GO:0050728	negative regulation of inflammatory response	Socs5	IMP		Mouse	MGI:MGI:5659826|PMID:24255059
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Socs5	IMP		Mouse	MGI:MGI:5659826|PMID:24255059
Biological Process	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	Socs5	IMP		Mouse	MGI:MGI:5659826|PMID:24255059
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	Socs5	IDA		Mouse	MGI:MGI:3687909|PMID:12242343
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	SOCS5	IMP		Human	PMID:15590694
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	Socs5	IDA		Mouse	MGI:MGI:3687909|PMID:12242343
Biological Process	GO:0097699	vascular endothelial cell response to fluid shear stress	Socs5	IMP		Mouse	MGI:MGI:5659826|PMID:24255059

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern