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Socs5 Gene Detail
Summary
  • Symbol
    Socs5
  • Name
    suppressor of cytokine signaling 5
  • Synonyms
    1810018L08Rik, Cish5, SOCS-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385459
    NCBI Gene: 56468
  • Gene Overview
    MyGene.info: SOCS5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:87107679-87137583 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 56.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    254 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385459
protein coding gene Chr17:87107295-87137647 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024099
protein coding gene Chr17:90470905-90500975 (+)
A/J MGP_AJ_G0024058
protein coding gene Chr17:87562218-87592094 (+)
AKR/J MGP_AKRJ_G0024027
protein coding gene Chr17:89030571-89060493 (+)
BALB/cJ MGP_BALBcJ_G0024059
protein coding gene Chr17:87410442-87441632 (+)
C3H/HeJ MGP_C3HHeJ_G0023824
protein coding gene Chr17:89902344-89932270 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024504
protein coding gene Chr17:93595507-93625385 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021943
protein coding gene Chr17:82705293-82734351 (+)
CAST/EiJ MGP_CASTEiJ_G0023303
protein coding gene Chr17:90726316-90757382 (+)
CBA/J MGP_CBAJ_G0023798
protein coding gene Chr17:97526992-97556875 (+)
DBA/2J MGP_DBA2J_G0023926
protein coding gene Chr17:85999274-86029175 (+)
FVB/NJ MGP_FVBNJ_G0023892
protein coding gene Chr17:85509759-85539662 (+)
LP/J MGP_LPJ_G0024010
protein coding gene Chr17:91256080-91287225 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023920
protein coding gene Chr17:97427260-97457182 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024549
protein coding gene Chr17:89545753-89575676 (+)
PWK/PhJ MGP_PWKPhJ_G0023048
protein coding gene Chr17:85638282-85668579 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022859
protein coding gene Chr17:86302401-86331943 (+)
WSB/EiJ MGP_WSBEiJ_G0023369
protein coding gene Chr17:90385577-90416319 (+)



Homology
more
  • Human Ortholog
    SOCS5, suppressor of cytokine signaling 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOCS5, suppressor of cytokine signaling 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CIS6, Cish5, CISH6, SOCS-5
  • Links
    NCBI Gene ID: 9655
    neXtProt AC: NX_O75159
    UniProt: O75159

  • Chr Location
    2p21; chr2:46698960-46762788 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are viable and fertile with normal immune system morphology and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037104 Ensembl Gene Model | MGI Sequence Detail 29905 C57BL/6J ±  kb
transcript ENSMUST00000041369 Ensembl | MGI Sequence Detail 4392 Not Applicable  
polypeptide ENSMUSP00000038591 Ensembl | MGI Sequence Detail 536 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 63
    cDNA 63

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916302
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:51029 Hilton DJ, et al., Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):114-9
  • Latest
    J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory