Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLX4
  • Mouse genes Slx4
  • Rat genes Slx4
  • Zfish genes slx4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slx4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008047	enzyme activator activity	SLX4	IDA		Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q92889	Human	PMID:19595721
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q9BQ83	Human	PMID:19595721
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q92889	Human	PMID:19595722
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:P07992	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:P43246	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:P53350	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q15554	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q5VYV7	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q92889	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q96AY2	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q96NY9	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q9BQ83	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q9NYB0	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:P07992	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q15554	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q92889	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q96AY2	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q96NY9	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q9BQ83	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q15554	Human	PMID:24012755
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q92889	Human	PMID:24012755
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q96NY9	Human	PMID:24012755
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:P53350	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q96NY9	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:Q96NY9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLX4	IPI	UniProtKB:P53350	Human	PMID:32707033
Cellular Component	GO:0030054	cell junction	SLX4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000785	chromatin	SLX4	IDA		Human	PMID:19596235
Cellular Component	GO:0000781	chromosome, telomeric region	SLX4	IDA		Human	PMID:19596235
Cellular Component	GO:0000781	chromosome, telomeric region	SLX4	IDA		Human	PMID:24012755
Cellular Component	GO:0005829	cytosol	SLX4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SLX4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0033557	Slx1-Slx4 complex	SLX4	IDA		Human	PMID:19595721
Cellular Component	GO:0033557	Slx1-Slx4 complex	SLX4	IDA		Human	PMID:19596235
Cellular Component	GO:0033557	Slx1-Slx4 complex	SLX4	IDA		Human	PMID:19596236
Biological Process	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	SLX4	IMP		Human	PMID:19595721
Biological Process	GO:0006281	DNA repair	SLX4	IMP		Human	PMID:19595722
Biological Process	GO:0000724	double-strand break repair via homologous recombination	SLX4	IMP		Human	PMID:19595721
Biological Process	GO:0000724	double-strand break repair via homologous recombination	SLX4	IMP		Human	PMID:19596235
Biological Process	GO:0061010	gallbladder development	slx4	IMP	ZFIN:ZDB-GENO-151130-1	Zfish	PMID:25947162
Biological Process	GO:0061011	hepatic duct development	slx4	IMP	ZFIN:ZDB-GENO-151130-1	Zfish	PMID:25947162
Biological Process	GO:0061008	hepaticobiliary system development	slx4	IMP	ZFIN:ZDB-GENO-151130-1	Zfish	PMID:25947162
Biological Process	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	SLX4	IMP		Human	PMID:24012755
Biological Process	GO:0006289	nucleotide-excision repair	SLX4	IMP		Human	PMID:19596236
Biological Process	GO:1904431	positive regulation of t-circle formation	Slx4	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0032206	positive regulation of telomere maintenance	SLX4	IDA		Human	PMID:24012755
Biological Process	GO:0072429	response to intra-S DNA damage checkpoint signaling	SLX4	IMP		Human	PMID:23361013
Biological Process	GO:0090656	t-circle formation	SLX4	IMP		Human	PMID:24012755
Biological Process	GO:0090656	t-circle formation	Slx4	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0061820	telomeric D-loop disassembly	SLX4	IMP		Human	PMID:24012755

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern