Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLK
  • Mouse genes Slk
  • Rat genes Slk
  • Zfish genes slka,slkb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	SLK	HDA		Human	PMID:25468996
Molecular Function	GO:0035173	histone kinase activity	Slk	IDA		Rat	PMID:21572393|RGD:9587767
Molecular Function	GO:0042802	identical protein binding	SLK	IPI	UniProtKB:Q9H2G2	Human	PMID:18239682
Molecular Function	GO:0005515	protein binding	SLK	IPI	UniProtKB:P61969	Human	PMID:25882817
Molecular Function	GO:0005515	protein binding	SLK	IPI	UniProtKB:F6ZDS4	Human	PMID:26094769
Molecular Function	GO:0005515	protein binding	Slk	IPI	UniProtKB:P61969	Mouse	MGI:MGI:5751633|PMID:25882817
Molecular Function	GO:0005515	protein binding	Slk	IPI	UniProtKB:O55203|UniProtKB:P70662	Mouse	MGI:MGI:5751678|PMID:19675209
Molecular Function	GO:0005515	protein binding	Slk	IPI	RGD:619921	Rat	PMID:18420945|RGD:2306409
Molecular Function	GO:0005515	protein binding	Slk	IPI	RGD:621227	Rat	PMID:21572393|RGD:9587767
Molecular Function	GO:0042803	protein homodimerization activity	SLK	IDA		Human	PMID:18239682
Molecular Function	GO:0042803	protein homodimerization activity	SLK	IDA		Human	PMID:22203681
Molecular Function	GO:0004672	protein kinase activity	Slk	IDA		Rat	PMID:18420945|RGD:2306409
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SLK	IDA		Human	PMID:18239682
Cellular Component	GO:0031252	cell leading edge	Slk	IDA		Mouse	MGI:MGI:5751633|PMID:25882817
Cellular Component	GO:0005737	cytoplasm	SLK	IDA		Human	PMID:18287541
Cellular Component	GO:0005737	cytoplasm	SLK	IDA		Human	PMID:26094769
Cellular Component	GO:0005737	cytoplasm	Slk	IDA		Rat	PMID:12965890|RGD:2304069
Cellular Component	GO:0070062	extracellular exosome	SLK	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SLK	HDA		Human	PMID:19199708
Cellular Component	GO:0048471	perinuclear region of cytoplasm	SLK	IDA		Human	PMID:26094769
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Slk	IEP		Rat	PMID:21572393|RGD:9587767
Biological Process	GO:0071346	cellular response to type II interferon	Slk	IDA		Rat	PMID:21572393|RGD:9587767
Biological Process	GO:0031122	cytoplasmic microtubule organization	SLK	IMP		Human	PMID:18287541
Biological Process	GO:0043065	positive regulation of apoptotic process	Slk	IMP		Rat	PMID:21572393|RGD:9587767
Biological Process	GO:0046777	protein autophosphorylation	SLK	IDA		Human	PMID:18239682
Biological Process	GO:0046777	protein autophosphorylation	Slk	IDA		Rat	PMID:12965890|RGD:2304069
Biological Process	GO:0006468	protein phosphorylation	Slk	IDA		Rat	PMID:12965890|RGD:2304069
Biological Process	GO:0042981	regulation of apoptotic process	SLK	IDA		Human	PMID:22203681
Biological Process	GO:0030334	regulation of cell migration	SLK	IMP		Human	PMID:26818812
Biological Process	GO:0030334	regulation of cell migration	Slk	IMP		Mouse	MGI:MGI:5751633|PMID:25882817
Biological Process	GO:0051893	regulation of focal adhesion assembly	SLK	IDA		Human	PMID:23128389

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern