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Slk Gene Detail
Summary
  • Symbol
    Slk
  • Name
    STE20-like kinase
  • Synonyms
    9A2, Etk4, mKIAA0204, mSLK, SLK, Stk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103241
    NCBI Gene: 20874
  • Gene Overview
    MyGene.info: SLK
Location & Maps
more
  • Sequence Map
    Chr19:47579678-47645246 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65569 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLK, STE20 like kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLK, STE20 like kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA16H23.1, LOSK, se20-9, STK2
  • Links
    NCBI Gene ID: 9748
    neXtProt AC: NX_Q9H2G2

  • Chr Location
    10q24.33; chr10:103967182-104029233 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 22515
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
  • HCOP
    human homology predictions: SLK
  • Gene Tree
    Slk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die by E14.5, exhibiting severe developmental defects, impaired neuronal and skeletal muscle development, abnormal placental differentiation and vascularization, and increased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029687 VEGA Gene Model | MGI Sequence Detail 65569 C57BL/6J ±  kb
transcript OTTMUST00000073655 VEGA | MGI Sequence Detail 4239 Not Applicable  
polypeptide OTTMUSP00000038163 VEGA | MGI Sequence Detail 1233 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    303 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 192
    Genomic 1
    cDNA 191

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-24116, MGI:2147668, MGI:2147725
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:13545 Biesecker LG, et al., Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
  • Latest
    J:229328 Baron KD, et al., Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4. Biochim Biophys Acta. 2015 Jul;1853(7):1683-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory