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Slk Gene Detail
Summary
  • Symbol
    Slk
  • Name
    STE20-like kinase
  • Synonyms
    9A2, Etk4, mKIAA0204, mSLK, SLK, Stk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103241
    NCBI Gene: 20874
  • Gene Overview
    MyGene.info: SLK
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:47579678-47645246 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65569 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 39.77 cM, cytoband D2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLK, STE20 like kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLK, STE20 like kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA16H23.1, LOSK, se20-9, STK2
  • Links
    NCBI Gene ID: 9748
    neXtProt AC: NX_Q9H2G2
    UniProt: Q9H2G2

  • Chr Location
    10q24.33-q25.1; chr10:103967173-104029233 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22515
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
  • HCOP
    human homology predictions: SLK
  • Gene Tree
    Slk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die by E14.5, exhibiting severe developmental defects, impaired neuronal and skeletal muscle development, abnormal placental differentiation and vascularization, and increased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029687 VEGA Gene Model | MGI Sequence Detail 65569 C57BL/6J ±  kb
    transcript OTTMUST00000073655 VEGA | MGI Sequence Detail 4239 Not Applicable  
    polypeptide OTTMUSP00000038163 VEGA | MGI Sequence Detail 1233 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      303 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 193
      Genomic 1
      cDNA 192

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-24116, MGI:2147668, MGI:2147725
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:31015 Hanks SK, et al., The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988 Jul 1;241(4861):42-52
    • Latest
      J:253620 Pryce BR, et al., Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. Skelet Muscle. 2017 Feb 2;7(1):3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory