Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc7a5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC7A5
- Mouse genes Slc7a5
- Rat genes Slc7a5
- Zfish genes slc7a5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc7a5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A5	IMP		Human	PMID:23567998
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A5	IDA		Human	PMID:26305885
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A5	IMP		Human	PMID:30374619
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	Slc7a5	IMP		Rat	PMID:28490336\|RGD:30309939
Molecular Function	GO:0015297	antiporter activity	SLC7A5	IDA		Human	PMID:11847106
Molecular Function	GO:0015173	aromatic amino acid transmembrane transporter activity	SLC7A5	IGI	UniProtKB:P08195	Human	PMID:15589117
Molecular Function	GO:0015179	L-amino acid transmembrane transporter activity	Slc7a5	IDA		Mouse	PMID:15659399
Molecular Function	GO:0015190	L-leucine transmembrane transporter activity	SLC7A5	IDA		Human	PMID:19075510
Molecular Function	GO:0015190	L-leucine transmembrane transporter activity	SLC7A5	IMP		Human	PMID:24038088
Molecular Function	GO:0015190	L-leucine transmembrane transporter activity	SLC7A5	IDA		Human	PMID:30867591
Molecular Function	GO:0015196	L-tryptophan transmembrane transporter activity	SLC7A5	IDA		Human	PMID:30867591
Molecular Function	GO:0015175	neutral L-amino acid transmembrane transporter activity	SLC7A5	IMP		Human	PMID:17197568
Molecular Function	GO:0015175	neutral L-amino acid transmembrane transporter activity	SLC7A5	IMP		Human	PMID:26050671
Molecular Function	GO:0015175	neutral L-amino acid transmembrane transporter activity	SLC7A5	IDA		Human	PMID:26305885
Molecular Function	GO:0005515	protein binding	SLC7A5	IPI	UniProtKB:Q86VI4	Human	PMID:25998567
Molecular Function	GO:0005515	protein binding	SLC7A5	IPI	UniProtKB:P08195	Human	PMID:30867591
Molecular Function	GO:0005515	protein binding	SLC7A5	IPI	UniProtKB:Q6P1M3	Human	PMID:30996345
Molecular Function	GO:0005515	protein binding	SLC7A5	IPI	UniProtKB:P08195-1	Human	PMID:31160781
Molecular Function	GO:0015349	thyroid hormone transmembrane transporter activity	SLC7A5	IDA		Human	PMID:26305885
Cellular Component	GO:1990184	amino acid transport complex	SLC7A5	IDA		Human	PMID:30867591
Cellular Component	GO:0016324	apical plasma membrane	SLC7A5	IDA		Human	PMID:11742812
Cellular Component	GO:0016324	apical plasma membrane	SLC7A5	IDA		Human	PMID:31791063
Cellular Component	GO:0016324	apical plasma membrane	Slc7a5	IDA		Rat	PMID:25089378\|RGD:151361121
Cellular Component	GO:0016324	apical plasma membrane	Slc7a5	IDA		Rat	PMID:11095508\|RGD:30309922
Cellular Component	GO:0009925	basal plasma membrane	Slc7a5	IDA		Rat	PMID:18619525\|RGD:2301072
Cellular Component	GO:0009925	basal plasma membrane	Slc7a5	IDA		Rat	PMID:11095508\|RGD:30309922
Cellular Component	GO:0016323	basolateral plasma membrane	Slc7a5	IDA		Rat	PMID:18619525\|RGD:2301072
Cellular Component	GO:0005737	cytoplasm	Slc7a5	IDA		Rat	PMID:28339760\|RGD:151361118
Cellular Component	GO:0005829	cytosol	SLC7A5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098591	external side of apical plasma membrane	Slc7a5	IDA		Rat	PMID:18619525\|RGD:2301072
Cellular Component	GO:0070062	extracellular exosome	SLC7A5	HDA		Human	PMID:20458337
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SLC7A5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	SLC7A5	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	SLC7A5	IDA		Human	PMID:30867591
Cellular Component	GO:0031528	microvillus membrane	SLC7A5	IDA		Human	PMID:26050671
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:11557028
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:12225859
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:16496379
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:25998567
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:9751058
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:19075510
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	SLC7A5	IDA		Human	PMID:28112518
Cellular Component	GO:0005886	plasma membrane	Slc7a5	IDA		Mouse	MGI:MGI:1329273\|PMID:9915839
Cellular Component	GO:0005886	plasma membrane	Slc7a5	IDA		Rat	PMID:11311135\|RGD:155230809
Cellular Component	GO:0005886	plasma membrane	Slc7a5	IDA		Rat	PMID:28339760\|RGD:151361118
Biological Process	GO:0032328	alanine transport	SLC7A5	IDA		Human	PMID:18262359
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC7A5	IMP		Human	PMID:23567998
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC7A5	IDA		Human	PMID:26305885
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC7A5	IMP		Human	PMID:30374619
Biological Process	GO:0089718	amino acid import across plasma membrane	Slc7a5	IMP		Rat	PMID:28490336\|RGD:30309939
Biological Process	GO:0071230	cellular response to amino acid stimulus	Slc7a5	IEP		Rat	PMID:9882595\|RGD:151357002
Biological Process	GO:0042149	cellular response to glucose starvation	Slc7a5	IEP		Rat	PMID:22185814\|RGD:151361127
Biological Process	GO:1903577	cellular response to L-arginine	Slc7a5	IEP		Rat	PMID:10681508\|RGD:151361135
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Slc7a5	IEP		Rat	PMID:29687865\|RGD:151357004
Biological Process	GO:0015818	isoleucine transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:0015818	isoleucine transport	Slc7a5	IDA		Rat	PMID:11311135\|RGD:155230809
Biological Process	GO:0015818	isoleucine transport	Slc7a5	IMP		Rat	PMID:25049270\|RGD:151361107
Biological Process	GO:0015807	L-amino acid transport	Slc7a5	IDA		Mouse	PMID:15659399
Biological Process	GO:0015807	L-amino acid transport	Slc7a5	IMP		Rat	PMID:15980244\|RGD:151361128
Biological Process	GO:1902024	L-histidine transport	SLC7A5	IDA		Human	PMID:10049700
Biological Process	GO:1902024	L-histidine transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:1902024	L-histidine transport	SLC7A5	IDA		Human	PMID:9751058
Biological Process	GO:1903801	L-leucine import across plasma membrane	SLC7A5	IDA		Human	PMID:19075510
Biological Process	GO:1903801	L-leucine import across plasma membrane	SLC7A5	IMP		Human	PMID:24038088
Biological Process	GO:1904556	L-tryptophan transmembrane transport	SLC7A5	IDA		Human	PMID:30867591
Biological Process	GO:0098713	leucine import across plasma membrane	SLC7A5	IMP		Human	PMID:17197568
Biological Process	GO:0098713	leucine import across plasma membrane	SLC7A5	IMP		Human	PMID:26050671
Biological Process	GO:0098713	leucine import across plasma membrane	SLC7A5	IDA		Human	PMID:26305885
Biological Process	GO:0015820	leucine transport	SLC7A5	IDA		Human	PMID:10049700
Biological Process	GO:0015820	leucine transport	SLC7A5	IDA		Human	PMID:10574970
Biological Process	GO:0015820	leucine transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:0015820	leucine transport	SLC7A5	IDA		Human	PMID:11564694
Biological Process	GO:0015820	leucine transport	SLC7A5	IDA		Human	PMID:12225859
Biological Process	GO:0015820	leucine transport	SLC7A5	IDA		Human	PMID:15769744
Biological Process	GO:0015820	leucine transport	SLC7A5	IDA		Human	PMID:9751058
Biological Process	GO:0015820	leucine transport	Slc7a5	IDA		Mouse	MGI:MGI:1329273\|PMID:9915839
Biological Process	GO:0015820	leucine transport	Slc7a5	IDA		Rat	PMID:15980244\|RGD:151361128
Biological Process	GO:0015820	leucine transport	Slc7a5	IDA		Rat	PMID:9726963\|RGD:634189
Biological Process	GO:0097421	liver regeneration	Slc7a5	IEP		Rat	PMID:9882595\|RGD:151357002
Biological Process	GO:0015821	methionine transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:0015821	methionine transport	SLC7A5	IDA		Human	PMID:12117417
Biological Process	GO:0010507	negative regulation of autophagy	Slc7a5	IMP		Rat	PMID:25049270\|RGD:151361107
Biological Process	GO:0010629	negative regulation of gene expression	SLC7A5	IMP		Human	PMID:24038088
Biological Process	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	Slc7a5	IDA		Rat	PMID:29687865\|RGD:151357004
Biological Process	GO:0015804	neutral amino acid transport	SLC7A5	IDA		Human	PMID:11847106
Biological Process	GO:0042476	odontogenesis	Slc7a5	IEP		Rat	PMID:15027953\|RGD:151361134
Biological Process	GO:0015823	phenylalanine transport	SLC7A5	IDA		Human	PMID:10049700
Biological Process	GO:0015823	phenylalanine transport	SLC7A5	IDA		Human	PMID:10574970
Biological Process	GO:0015823	phenylalanine transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:0015823	phenylalanine transport	SLC7A5	IDA		Human	PMID:11564694
Biological Process	GO:0015823	phenylalanine transport	SLC7A5	IGI	UniProtKB:P08195	Human	PMID:15589117
Biological Process	GO:0015823	phenylalanine transport	SLC7A5	IDA		Human	PMID:9751058
Biological Process	GO:0060252	positive regulation of glial cell proliferation	Slc7a5	IMP		Rat	PMID:16496379\|RGD:151361115
Biological Process	GO:0032740	positive regulation of interleukin-17 production	SLC7A5	IMP		Human	PMID:24038088
Biological Process	GO:0032753	positive regulation of interleukin-4 production	SLC7A5	IMP		Human	PMID:24038088
Biological Process	GO:1905534	positive regulation of leucine import across plasma membrane	Slc7a5	IMP		Rat	PMID:25049270\|RGD:151361107
Biological Process	GO:0032729	positive regulation of type II interferon production	SLC7A5	IMP		Human	PMID:24038088
Biological Process	GO:0015824	proline transport	SLC7A5	IDA		Human	PMID:10574970
Biological Process	GO:0055093	response to hyperoxia	Slc7a5	IEP		Rat	PMID:25089378\|RGD:151361121
Biological Process	GO:0014850	response to muscle activity	Slc7a5	IEP		Rat	PMID:24016666\|RGD:151361119
Biological Process	GO:0070327	thyroid hormone transport	SLC7A5	IDA		Human	PMID:11564694
Biological Process	GO:0070327	thyroid hormone transport	SLC7A5	IDA		Human	PMID:26305885
Biological Process	GO:0015827	tryptophan transport	SLC7A5	IDA		Human	PMID:10049700
Biological Process	GO:0015827	tryptophan transport	SLC7A5	IDA		Human	PMID:10574970
Biological Process	GO:0015827	tryptophan transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:0015827	tryptophan transport	SLC7A5	IDA		Human	PMID:11564694
Biological Process	GO:0015827	tryptophan transport	Slc7a5	IDA		Rat	PMID:12614332\|RGD:155230770
Biological Process	GO:0015828	tyrosine transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:0015828	tyrosine transport	SLC7A5	IDA		Human	PMID:11564694
Biological Process	GO:0015828	tyrosine transport	SLC7A5	IDA		Human	PMID:18262359
Biological Process	GO:0015829	valine transport	SLC7A5	IDA		Human	PMID:11557028
Biological Process	GO:0015829	valine transport	Slc7a5	IMP		Rat	PMID:25049270\|RGD:151361107
Biological Process	GO:0042908	xenobiotic transport	SLC7A5	IMP		Human	PMID:23567998
Biological Process	GO:0042908	xenobiotic transport	SLC7A5	IMP		Human	PMID:30374619

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.