Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC25A12
  • Mouse genes Slc25a12
  • Rat genes Slc25a12
  • Zfish genes slc25a12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc25a12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000514	3-sulfino-L-alanine: proton, glutamate antiporter activity	SLC25A12	IDA		Human	PMID:11566871
Molecular Function	GO:0015172	acidic amino acid transmembrane transporter activity	SLC25A12	EXP		Human	PMID:11566871
Molecular Function	GO:0015172	acidic amino acid transmembrane transporter activity	Slc25a12	IMP	MGI:MGI:3603462	Mouse	PMID:15987682
Molecular Function	GO:0000515	aspartate:glutamate, proton antiporter activity	SLC25A12	IDA		Human	PMID:11566871
Molecular Function	GO:0000515	aspartate:glutamate, proton antiporter activity	SLC25A12	IDA		Human	PMID:24515575
Molecular Function	GO:0005509	calcium ion binding	SLC25A12	IDA		Human	PMID:25410934
Molecular Function	GO:0005509	calcium ion binding	SLC25A12	IDA		Human	PMID:9722566
Molecular Function	GO:0042802	identical protein binding	SLC25A12	IDA		Human	PMID:25410934
Molecular Function	GO:0005515	protein binding	SLC25A12	IPI	UniProtKB:Q7Z434	Human	PMID:31767682
Cellular Component	GO:0005743	mitochondrial inner membrane	SLC25A12	IDA		Human	PMID:11566871
Cellular Component	GO:0005743	mitochondrial inner membrane	Slc25a12	IMP	MGI:MGI:3603462	Mouse	PMID:15987682
Cellular Component	GO:0005743	mitochondrial inner membrane	Slc25a12	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	SLC25A12	IDA		Human	PMID:11566871
Cellular Component	GO:0005739	mitochondrion	SLC25A12	IDA		Human	PMID:19641205
Cellular Component	GO:0005739	mitochondrion	SLC25A12	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	SLC25A12	IDA		Human	PMID:24515575
Cellular Component	GO:0005739	mitochondrion	SLC25A12	IDA		Human	PMID:9722566
Cellular Component	GO:0005739	mitochondrion	Slc25a12	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Slc25a12	IDA		Mouse	PMID:14701727
Cellular Component	GO:0005739	mitochondrion	Slc25a12	IMP	MGI:MGI:3603462	Mouse	PMID:17213189
Cellular Component	GO:0043209	myelin sheath	Slc25a12	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Biological Process	GO:0015810	aspartate transmembrane transport	SLC25A12	IDA		Human	PMID:11566871
Biological Process	GO:0015810	aspartate transmembrane transport	SLC25A12	IDA		Human	PMID:19641205
Biological Process	GO:0015810	aspartate transmembrane transport	SLC25A12	IDA		Human	PMID:24515575
Biological Process	GO:0006537	glutamate biosynthetic process	Slc25a12	IMP		Rat	PMID:19764902|RGD:13628741
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC25A12	IDA		Human	PMID:11566871
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC25A12	IDA		Human	PMID:19641205
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC25A12	IDA		Human	PMID:24515575
Biological Process	GO:0043490	malate-aspartate shuttle	SLC25A12	IDA		Human	PMID:11566871
Biological Process	GO:0043490	malate-aspartate shuttle	Slc25a12	IMP	MGI:MGI:3603462	Mouse	PMID:17213189
Biological Process	GO:0043490	malate-aspartate shuttle	Slc25a12	IMP		Rat	PMID:19764902|RGD:13628741
Biological Process	GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate	Slc25a12	IMP		Rat	PMID:19764902|RGD:13628741
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	Slc25a12	IMP		Rat	PMID:19764902|RGD:13628741
Biological Process	GO:0010907	positive regulation of glucose metabolic process	Slc25a12	IMP		Rat	PMID:19764902|RGD:13628741
Biological Process	GO:0031643	positive regulation of myelination	Slc25a12	IMP		Rat	PMID:20015484|RGD:13628737
Biological Process	GO:0051592	response to calcium ion	SLC25A12	IDA		Human	PMID:11566871

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern