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Slc25a12
Gene Detail
Symbol

Name
ID
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
MGI:1926080
Synonyms
B230107K20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:71271063-71367749 bp, - strand
From VEGA annotation of GRCm38

  96687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48235  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC25A12
Gene Tree: Slc25a12

Human
homologs
SLC25A12, solute carrier family 25 (aspartate/glutamate carrier), member 12
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8604
neXtProt AC: NX_O75746

Human Synonyms: AGC1, ARALAR

Human Chr (Location): 2q24; chr2:171783405-171894306 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC25A12

Mutations,
alleles, and
phenotypes
All mutations/alleles(122) : Gene trapped(122)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele show severe growth defects, generalized tremors, postnatal lethality, impaired motor coordination, and CNS dysmyelination associated with decreased synthesis of myelin lipids and a striking reduction in brain aspartate and N-acetylaspartate levels.
 
Interactions
Slc25a12 interacts with 405 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process aspartate transport, L-aspartate transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function calcium ion binding, L-aspartate transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (6)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase slc25a12 ; ZFIN slc25a12    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000013185 (Evidence)
Ensembl Gene Model ENSMUSG00000027010 (Evidence)
Entrez Gene 78830 (Evidence)
DFCI TC1575716, TC1607485, TC1717817
DoTS DT.101151232, DT.40164755, DT.40181348, DT.87069150, DT.94180826
NIA Mouse Gene Index U022726, U022727
Consensus CDS Project CCDS16113.1
International Mouse Phenotyping Consortium Status Slc25a12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013185 VEGA Gene Model | MGI Sequence Detail 96687 C57BL/6J ±  kb
transcript OTTMUST00000031854 VEGA | MGI Sequence Detail 6351 Not Applicable 
polypeptide OTTMUSP00000014191 VEGA | MGI Sequence Detail 677 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(1231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR002067 Mitochondrial carrier protein
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000015007 calcium-binding mitochondrial carrier protein Aralar1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:216575 Lindsay KJ, et al., Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15579-84
All references(44)
Other
accession IDs
MGI:2139062, MGI:2139433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory