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Slc25a12
Gene Detail
Symbol

Name
ID
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
MGI:1926080
Synonyms
B230107K20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:71271063-71367749 bp, - strand
From VEGA annotation of GRCm38

  96687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48235  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc25a12

Human
homologs
Human Homolog SLC25A12, solute carrier family 25 (aspartate/glutamate carrier), member 12
NCBI Gene ID 8604
neXtProt AC  NX_O75746
Human Synonyms  AGC1, ARALAR
Human Chr (Location)  2q24; chr2:171783405-171894306 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC25A12
Mutations,
alleles, and
phenotypes
All mutations/alleles(122) : Gene trapped(122)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show severe growth defects, generalized tremors, postnatal lethality, impaired motor coordination, and CNS dysmyelination associated with decreased synthesis of myelin lipids and a striking reduction in brain aspartate and N-acetylaspartate levels.
 
Interactions
Slc25a12 interacts with 406 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (6)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000013185 (Evidence)
Ensembl Gene ModelENSMUSG00000027010 (Evidence)
Entrez Gene78830 (Evidence)
DFCITC1575716, TC1607485, TC1717817
DoTSDT.101151232, DT.40164755, DT.40181348, DT.87069150, DT.94180826
NIA Mouse Gene IndexU022726, U022727
Consensus CDS ProjectCCDS16113.1
International Mouse Knockout Project StatusSlc25a12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013185 VEGA Gene Model | MGI Sequence Detail 96687 C57BL/6J ±  kb
transcript OTTMUST00000031854 VEGA | MGI Sequence Detail 6351 Not Applicable 
polypeptide OTTMUSP00000014191 VEGA | MGI Sequence Detail 677 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(1231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR002067 Mitochondrial carrier protein
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000015007 calcium-binding mitochondrial carrier protein Aralar1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202932 Du J, et al., Cytosolic reducing power preserves glutamate in retina. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18501-6
All references(44)
Other
accession IDs
MGI:2139062, MGI:2139433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory