Slc25a12
Gene Detail

Symbol

Name
ID

Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
MGI:1926080

Synonyms

B230107K20Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:71271063-71367749 bp, - strand From VEGA annotation of GRCm38   96687 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:48235  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc25a12

Human
homologs

Human Homolog		SLC25A12, solute carrier family 25 (aspartate/glutamate carrier), member 12
NCBI Gene ID		8604
neXtProt AC		NX_O75746
Human Synonyms		AGC1, ARALAR
Human Chr (Location)		2q24; chr2:171783405-171894306 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human SLC25A12

Mutations,
alleles, and
phenotypes

All mutations/alleles(122) : Gene trapped(122)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele show severe growth defects, generalized tremors, postnatal lethality, impaired motor coordination, and CNS dysmyelination associated with decreased synthesis of myelin lipids and a striking reduction in brain aspartate and N-acetylaspartate levels.

 

Interactions

Slc25a12 interacts with 406 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (21 annotations)

Process	aspartate transport, L-aspartate transmembrane transport, ...
Component	integral component of membrane, membrane, ...
Function	calcium ion binding, L-aspartate transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (10)    Tissues (6)    Images (6)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	10

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000013185 (Evidence)
Ensembl Gene Model	ENSMUSG00000027010 (Evidence)
Entrez Gene	78830 (Evidence)
DFCI	TC1575716, TC1717817, TC1607485
DoTS	DT.101151232, DT.40164755, DT.94180826, DT.40181348, DT.87069150
NIA Mouse Gene Index	U022727, U022726
Consensus CDS Project	CCDS16113.1
International Mouse Knockout Project Status	Slc25a12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013185	VEGA Gene Model | MGI Sequence Detail	96687	C57BL/6J
transcript	OTTMUST00000031854	VEGA | MGI Sequence Detail	6351	Not Applicable
polypeptide	OTTMUSP00000014191	VEGA | MGI Sequence Detail	677	Not Applicable

All sequences(70) RefSeq(6) UniProt(3)

Polymorphisms

SNPs within 2kb(1231 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR023395	Mitochondrial carrier domain
InterPro	IPR002067	Mitochondrial carrier protein
InterPro	IPR018108	Mitochondrial substrate/solute carrier
Protein Ontology	PR:000015007	calcium-binding mitochondrial carrier protein Aralar1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202932 Du J, et al., Cytosolic reducing power preserves glutamate in retina. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18501-6
All references(45)

Other
accession IDs

MGI:2139062, MGI:2139433