Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc22a3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC22A3
- Mouse genes Slc22a3
- Rat genes Slc22a3
- Zfish genes slc22a3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc22a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc22a3	IDA		Rat	PMID:9830022\|RGD:1643215
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A3	IDA		Human	PMID:10196521
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A3	IDA		Human	PMID:16581093
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A3	IDA		Human	PMID:20858707
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A3	IMP		Human	PMID:23505051
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc22a3	IDA		Rat	PMID:16581093\|RGD:155663558
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	SLC22A3	IDA		Human	PMID:10196521
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	SLC22A3	IDA		Human	PMID:16581093
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	SLC22A3	IDA		Human	PMID:20858707
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	SLC22A3	IMP		Human	PMID:23505051
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	Slc22a3	IDA		Rat	PMID:16581093\|RGD:155663558
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	Slc22a3	IDA		Rat	PMID:20924140\|RGD:30309940
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A3	IDA		Human	PMID:10966924
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A3	IDA		Human	PMID:16024787
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A3	IDA		Human	PMID:17460754
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A3	EXP		Human	PMID:19141712
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A3	IDA		Human	PMID:22806583
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A3	IDA		Human	PMID:24291757
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a3	IDA		Mouse	PMID:10966924
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a3	IDA		Rat	PMID:9632645\|RGD:70010
Molecular Function	GO:0005515	protein binding	SLC22A3	IPI	UniProtKB:P00519	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	Slc22a3	IPI	UniProtKB:Q9WV19	Rat	PMID:11238452\|RGD:2324636
Molecular Function	GO:0005515	protein binding	Slc22a3	IPI	UniProtKB:Q9WVI9	Rat	PMID:11238452\|RGD:2324636
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A3	IDA		Human	PMID:10966924
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A3	IDA		Human	PMID:20858707
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a3	IDA		Mouse	PMID:10966924
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a3	IMP		Rat	PMID:9632645\|RGD:70010
Molecular Function	GO:0015606	spermidine transmembrane transporter activity	Slc22a3	IDA		Rat	PMID:23458604\|RGD:155663537
Molecular Function	GO:0019534	toxin transmembrane transporter activity	SLC22A3	IDA		Human	PMID:22806583
Molecular Function	GO:0019534	toxin transmembrane transporter activity	SLC22A3	IDA		Human	PMID:24291757
Molecular Function	GO:0019534	toxin transmembrane transporter activity	Slc22a3	IDA		Rat	PMID:12411423\|RGD:1643218
Molecular Function	GO:0019534	toxin transmembrane transporter activity	Slc22a3	IDA		Rat	PMID:9830022\|RGD:1643215
Molecular Function	GO:0022857	transmembrane transporter activity	Slc22a3	IDA		Mouse	PMID:28543680
Cellular Component	GO:0016324	apical plasma membrane	SLC22A3	IDA		Human	PMID:15817714
Cellular Component	GO:0016324	apical plasma membrane	SLC22A3	IDA		Human	PMID:16263091
Cellular Component	GO:0016324	apical plasma membrane	Slc22a3	IDA		Mouse	MGI:MGI:7434543\|PMID:15817714
Cellular Component	GO:0016324	apical plasma membrane	Slc22a3	IDA		Rat	PMID:15817714\|RGD:2317432
Cellular Component	GO:0016323	basolateral plasma membrane	SLC22A3	IDA		Human	PMID:15817714
Cellular Component	GO:0012505	endomembrane system	Slc22a3	IDA		Mouse	MGI:MGI:6822945\|PMID:27659446
Cellular Component	GO:0012505	endomembrane system	Slc22a3	IDA		Rat	PMID:27659446\|RGD:155888561
Cellular Component	GO:0031966	mitochondrial membrane	Slc22a3	IDA		Mouse	MGI:MGI:6822945\|PMID:27659446
Cellular Component	GO:0031966	mitochondrial membrane	Slc22a3	IDA		Rat	PMID:27659446\|RGD:155888561
Cellular Component	GO:0043025	neuronal cell body	Slc22a3	IDA		Mouse	MGI:MGI:3805626\|PMID:18513366
Cellular Component	GO:0005886	plasma membrane	SLC22A3	IDA		Human	PMID:20858707
Cellular Component	GO:0005886	plasma membrane	SLC22A3	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	Slc22a3	IDA		Mouse	MGI:MGI:7434543\|PMID:15817714
Cellular Component	GO:0005886	plasma membrane	Slc22a3	IDA		Mouse	MGI:MGI:6436398\|PMID:20858707
Cellular Component	GO:0005886	plasma membrane	Slc22a3	IDA		Mouse	MGI:MGI:6822945\|PMID:27659446
Cellular Component	GO:0005886	plasma membrane	Slc22a3	IDA		Rat	PMID:27659446\|RGD:155888561
Biological Process	GO:0015872	dopamine transport	SLC22A3	IDA		Human	PMID:16581093
Biological Process	GO:0015872	dopamine transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0015872	dopamine transport	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Biological Process	GO:0015872	dopamine transport	Slc22a3	IDA		Rat	PMID:9830022\|RGD:1643215
Biological Process	GO:0090494	dopamine uptake	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0048241	epinephrine transport	SLC22A3	IDA		Human	PMID:10196521
Biological Process	GO:0048241	epinephrine transport	SLC22A3	IDA		Human	PMID:16581093
Biological Process	GO:0048241	epinephrine transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0048241	epinephrine transport	Slc22a3	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0051625	epinephrine uptake	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0051649	establishment of localization in cell	Slc22a3	IMP	MGI:MGI:2388117	Mouse	PMID:16061728
Biological Process	GO:0051608	histamine transport	SLC22A3	IDA		Human	PMID:16581093
Biological Process	GO:0051608	histamine transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0051608	histamine transport	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Biological Process	GO:0051608	histamine transport	Slc22a3	IMP	MGI:MGI:2388117	Mouse	PMID:16061728
Biological Process	GO:0051608	histamine transport	Slc22a3	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0051615	histamine uptake	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0051615	histamine uptake	SLC22A3	IMP		Human	PMID:23505051
Biological Process	GO:0051615	histamine uptake	Slc22a3	IMP	MGI:MGI:2388117	Mouse	PMID:16061728
Biological Process	GO:0015844	monoamine transport	SLC22A3	IMP		Human	PMID:23505051
Biological Process	GO:0015844	monoamine transport	Slc22a3	IMP	MGI:MGI:2388117	Mouse	PMID:11390648
Biological Process	GO:0015718	monocarboxylic acid transport	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Biological Process	GO:0006836	neurotransmitter transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0006836	neurotransmitter transport	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Biological Process	GO:0015874	norepinephrine transport	SLC22A3	IDA		Human	PMID:10196521
Biological Process	GO:0015874	norepinephrine transport	SLC22A3	IDA		Human	PMID:16581093
Biological Process	GO:0015874	norepinephrine transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0015874	norepinephrine transport	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Biological Process	GO:0015874	norepinephrine transport	Slc22a3	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0051620	norepinephrine uptake	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0015711	organic anion transport	Slc22a3	IDA		Rat	PMID:20924140\|RGD:30309940
Biological Process	GO:0015695	organic cation transport	SLC22A3	IDA		Human	PMID:10966924
Biological Process	GO:0015695	organic cation transport	SLC22A3	IDA		Human	PMID:16024787
Biological Process	GO:0015695	organic cation transport	SLC22A3	IDA		Human	PMID:22806583
Biological Process	GO:0015695	organic cation transport	SLC22A3	IDA		Human	PMID:24291757
Biological Process	GO:0015695	organic cation transport	Slc22a3	IDA		Mouse	PMID:10966924
Biological Process	GO:0015695	organic cation transport	Slc22a3	IDA		Rat	PMID:12411423\|RGD:1643218
Biological Process	GO:0015695	organic cation transport	Slc22a3	IDA		Rat	PMID:9632645\|RGD:70010
Biological Process	GO:0015695	organic cation transport	Slc22a3	IDA		Rat	PMID:9830022\|RGD:1643215
Biological Process	GO:0015850	organic hydroxy compound transport	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A3	IDA		Human	PMID:10966924
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a3	IDA		Mouse	PMID:10966924
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a3	IMP		Rat	PMID:9632645\|RGD:70010
Biological Process	GO:0032098	regulation of appetite	Slc22a3	IMP	MGI:MGI:2388117	Mouse	PMID:15028779
Biological Process	GO:0006837	serotonin transport	SLC22A3	IDA		Human	PMID:10196521
Biological Process	GO:0006837	serotonin transport	SLC22A3	IDA		Human	PMID:16581093
Biological Process	GO:0006837	serotonin transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0006837	serotonin transport	Slc22a3	IMP		Mouse	MGI:MGI:3805626\|PMID:18513366
Biological Process	GO:0006837	serotonin transport	Slc22a3	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0051610	serotonin uptake	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0015848	spermidine transport	Slc22a3	IDA		Rat	PMID:23458604\|RGD:155663537
Biological Process	GO:1901998	toxin transport	SLC22A3	IDA		Human	PMID:22806583
Biological Process	GO:1901998	toxin transport	SLC22A3	IDA		Human	PMID:24291757
Biological Process	GO:0042908	xenobiotic transport	SLC22A3	IDA		Human	PMID:20858707
Biological Process	GO:0042908	xenobiotic transport	SLC22A3	IDA		Human	PMID:22806583
Biological Process	GO:0042908	xenobiotic transport	SLC22A3	IDA		Human	PMID:24291757

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.