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Slc22a3
Gene Detail
Symbol

Name
ID
Slc22a3
solute carrier family 22 (organic cation transporter), member 3
MGI:1333817
Synonyms
EMT, Oct3, Orct3
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:12419972-12507704 bp, - strand
From NCBI annotation of GRCm38

  87733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22630  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC22A3
Gene Tree: Slc22a3

Human
homologs
SLC22A3, solute carrier family 22 (organic cation transporter), member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6581
neXtProt AC: NX_O75751

Human Synonyms: EMT, EMTH, OCT3

Human Chr (Location): 6q25.3; chr6:160348373-160452581 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to paraquat-induced dopamine neuron neurotoxicity.
 
Interactions
Slc22a3 interacts with 193 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (9 records)
Data Summary: Results (107)    Tissues (24)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
Northern blot 43
RT-PCR 9
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(6) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000023828 (Evidence)
Entrez Gene 20519 (Evidence)
UniGene 99252
DFCI TC1587535
DoTS DT.524760, DT.55266042
NIA Mouse Gene Index U037424
Consensus CDS Project CCDS28391.1
International Mouse Phenotyping Consortium Status Slc22a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20519 NCBI Gene Model | MGI Sequence Detail 87733 C57BL/6J ±  kb
transcript NM_011395 RefSeq | MGI Sequence Detail 3501 C57BL/6 
polypeptide Q9WTW5 UniProt | EBI | MGI Sequence Detail 551 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 Major facilitator, sugar transporter-like
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004749 Organic cation transport protein
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000014990 solute carrier family 22 member 3
Graphical View of Protein Domain Structure
References
(Earliest) J:52875 Verhaagh S, et al., Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics. 1999 Jan 15;55(2):209-18
(Latest) J:222397 Kulinski TM, et al., Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory