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Slc22a3 Gene Detail
Summary
  • Symbol
    Slc22a3
  • Name
    solute carrier family 22 (organic cation transporter), member 3
  • Synonyms
    EMT, Oct3, Orct3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333817
    NCBI Gene: 20519
  • Gene Overview
    MyGene.info: SLC22A3
Location & Maps
more
  • Sequence Map
    Chr17:12419972-12507704 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87733 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC22A3, solute carrier family 22 member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC22A3, solute carrier family 22 member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EMT, EMTH, OCT3
  • Links
    NCBI Gene ID: 6581
    neXtProt AC: NX_O75751

  • Chr Location
    6q25.3; chr6:160348373-160452581 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to paraquat-induced dopamine neuron neurotoxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20519 NCBI Gene Model | MGI Sequence Detail 87733 C57BL/6J ±  kb
transcript NM_011395 RefSeq | MGI Sequence Detail 3501 C57BL/6  
polypeptide Q9WTW5 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    291 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014990 solute carrier family 22 member 3
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR004749 Organic cation transport protein/SVOP
    IPR005829 Sugar transporter, conserved site
Molecular
Reagents
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  • All nucleic 21
    Genomic 6
    cDNA 10
    Primer pair 4
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 9
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:52875 Verhaagh S, et al., Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics. 1999 Jan 15;55(2):209-18
  • Latest
    J:222397 Kulinski TM, et al., Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory