Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc22a2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC22A2
- Mouse genes Slc22a2
- Rat genes Slc22a2
- Zfish genes slc22a2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc22a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005277	acetylcholine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:15817714
Molecular Function	GO:0005277	acetylcholine transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:15817714\|RGD:2317432
Molecular Function	GO:0005275	amine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9687576
Molecular Function	GO:0015220	choline transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9687576
Molecular Function	GO:0015220	choline transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:11553644\|RGD:628453
Molecular Function	GO:0015562	efflux transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9687576
Molecular Function	GO:0015179	L-amino acid transmembrane transporter activity	SLC22A2	IMP		Human	PMID:23864433
Molecular Function	GO:0061459	L-arginine transmembrane transporter activity	SLC22A2	IMP		Human	PMID:23864433
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:12089365
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:15212162
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:16581093
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:17072098
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:17460754
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9687576
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:11758759\|RGD:155888557
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:16581093\|RGD:155663558
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:9812985\|RGD:155888554
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	SLC22A2	IDA		Human	PMID:16581093
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9687576
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:16581093\|RGD:155663558
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:9812985\|RGD:155888554
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	SLC22A2	IDA		Human	PMID:11907186
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:12089365
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:12538837
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:16024787
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:17460754
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	EXP		Human	PMID:19141712
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:21128598
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:22806583
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IMP		Human	PMID:23864433
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:24291757
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9260930
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9687576
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a2	IDA		Mouse	PMID:12176030
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:10889205\|RGD:155888564
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:11758759\|RGD:155888557
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:12538837\|RGD:1299324
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:18361503\|RGD:7243886
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:20924140\|RGD:30309940
Molecular Function	GO:0015132	prostaglandin transmembrane transporter activity	SLC22A2	IDA		Human	PMID:11907186
Molecular Function	GO:0015489	putrescine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:21128598
Molecular Function	GO:0015214	pyrimidine nucleoside transmembrane transporter activity	SLC22A2	IMP		Human	PMID:20477935
Molecular Function	GO:0015214	pyrimidine nucleoside transmembrane transporter activity	Slc22a2	IMP		Mouse	MGI:MGI:6436440\|PMID:20477935
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9260930
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:10889205\|RGD:155888564
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:9808712\|RGD:1643123
Molecular Function	GO:0005496	steroid binding	Slc22a2	IDA		Rat	PMID:14573752\|RGD:2317437
Molecular Function	GO:0015234	thiamine transmembrane transporter activity	SLC22A2	IDA		Human	PMID:24961373
Molecular Function	GO:0019534	toxin transmembrane transporter activity	SLC22A2	IMP		Human	PMID:20477935
Molecular Function	GO:0019534	toxin transmembrane transporter activity	SLC22A2	IDA		Human	PMID:22806583
Molecular Function	GO:0019534	toxin transmembrane transporter activity	SLC22A2	IDA		Human	PMID:24291757
Molecular Function	GO:0019534	toxin transmembrane transporter activity	SLC22A2	IDA		Human	PMID:9687576
Molecular Function	GO:0019534	toxin transmembrane transporter activity	Slc22a2	IMP		Mouse	MGI:MGI:6436440\|PMID:20477935
Molecular Function	GO:0019534	toxin transmembrane transporter activity	Slc22a2	IMP		Rat	PMID:20477935\|RGD:30309941
Molecular Function	GO:0019534	toxin transmembrane transporter activity	Slc22a2	IDA		Rat	PMID:20924140\|RGD:30309940
Molecular Function	GO:0022857	transmembrane transporter activity	slc22a2	IDA		Zfish	PMID:28363126
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	SLC22A2	IDA		Human	PMID:12395288
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	SLC22A2	IDA		Human	PMID:16394027
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	SLC22A2	IMP		Human	PMID:20477935
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	Slc22a2	IMP		Mouse	MGI:MGI:6436440\|PMID:20477935
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	Slc22a2	IMP		Rat	PMID:20477935\|RGD:30309941
Cellular Component	GO:0016324	apical plasma membrane	SLC22A2	IDA		Human	PMID:15817714
Cellular Component	GO:0016324	apical plasma membrane	SLC22A2	IDA		Human	PMID:20477935
Cellular Component	GO:0016324	apical plasma membrane	Slc22a2	IDA		Mouse	MGI:MGI:6436440\|PMID:20477935
Cellular Component	GO:0016324	apical plasma membrane	Slc22a2	IDA		Rat	PMID:15817714\|RGD:2317432
Cellular Component	GO:0016324	apical plasma membrane	Slc22a2	IDA		Rat	PMID:20477935\|RGD:30309941
Cellular Component	GO:0009925	basal plasma membrane	SLC22A2	IDA		Human	PMID:35307651
Cellular Component	GO:0016323	basolateral plasma membrane	Slc22a2	IDA		Rat	PMID:10997918\|RGD:1643124
Cellular Component	GO:0016323	basolateral plasma membrane	Slc22a2	IDA		Rat	PMID:11083459\|RGD:155663544
Cellular Component	GO:0016323	basolateral plasma membrane	Slc22a2	IDA		Rat	PMID:9808712\|RGD:1643123
Cellular Component	GO:0098981	cholinergic synapse	Slc22a2	IDA		Rat	PMID:23958595\|RGD:155230726
Cellular Component	GO:0070062	extracellular exosome	SLC22A2	HDA		Human	PMID:19056867
Cellular Component	GO:0005886	plasma membrane	SLC22A2	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	Slc22a2	IDA		Rat	PMID:11553644\|RGD:628453
Cellular Component	GO:0005886	plasma membrane	Slc22a2	IDA		Rat	PMID:12176030\|RGD:8553962
Cellular Component	GO:0005886	plasma membrane	slc22a2	IDA		Zfish	PMID:28363126
Cellular Component	GO:0042734	presynaptic membrane	Slc22a2	IDA		Rat	PMID:23958595\|RGD:155230726
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc22a2	IDA		Rat	PMID:23958595\|RGD:155230726
Biological Process	GO:0015870	acetylcholine transport	SLC22A2	IDA		Human	PMID:15817714
Biological Process	GO:0015870	acetylcholine transport	Slc22a2	IDA		Rat	PMID:15817714\|RGD:2317432
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Slc22a2	IMP		Rat	PMID:30120945\|RGD:30309911
Biological Process	GO:0015837	amine transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC22A2	IMP		Human	PMID:23864433
Biological Process	GO:0015871	choline transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0061371	determination of heart left/right asymmetry	slc22a2	IMP	ZFIN:ZDB-MRPHLNO-191114-5	Zfish	PMID:31075101
Biological Process	GO:0015872	dopamine transport	SLC22A2	IDA		Human	PMID:16581093
Biological Process	GO:0015872	dopamine transport	Slc22a2	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0015872	dopamine transport	Slc22a2	IDA		Rat	PMID:9812985\|RGD:155888554
Biological Process	GO:0090494	dopamine uptake	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0048241	epinephrine transport	SLC22A2	IDA		Human	PMID:16581093
Biological Process	GO:0048241	epinephrine transport	Slc22a2	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0048241	epinephrine transport	Slc22a2	IDA		Rat	PMID:9812985\|RGD:155888554
Biological Process	GO:0140115	export across plasma membrane	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0051608	histamine transport	SLC22A2	IDA		Human	PMID:16581093
Biological Process	GO:0051608	histamine transport	Slc22a2	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0051608	histamine transport	Slc22a2	IDA		Rat	PMID:16648665\|RGD:2317431
Biological Process	GO:0051615	histamine uptake	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:1902475	L-alpha-amino acid transmembrane transport	SLC22A2	IMP		Human	PMID:23864433
Biological Process	GO:0097638	L-arginine import across plasma membrane	SLC22A2	IMP		Human	PMID:23864433
Biological Process	GO:0006812	monoatomic cation transport	Slc22a2	IDA		Mouse	PMID:12176030
Biological Process	GO:0006836	neurotransmitter transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0015874	norepinephrine transport	SLC22A2	IDA		Human	PMID:16581093
Biological Process	GO:0015874	norepinephrine transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0015874	norepinephrine transport	Slc22a2	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0015874	norepinephrine transport	Slc22a2	IDA		Rat	PMID:9812985\|RGD:155888554
Biological Process	GO:0051620	norepinephrine uptake	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0015695	organic cation transport	SLC22A2	IDA		Human	PMID:16024787
Biological Process	GO:0015695	organic cation transport	SLC22A2	IDA		Human	PMID:22806583
Biological Process	GO:0015695	organic cation transport	SLC22A2	IMP		Human	PMID:23864433
Biological Process	GO:0015695	organic cation transport	SLC22A2	IDA		Human	PMID:24291757
Biological Process	GO:0015695	organic cation transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0015695	organic cation transport	Slc22a2	IDA		Rat	PMID:19211691\|RGD:2317436
Biological Process	GO:0015695	organic cation transport	Slc22a2	IDA		Rat	PMID:20924140\|RGD:30309940
Biological Process	GO:0010628	positive regulation of gene expression	Slc22a2	IMP		Rat	PMID:30120945\|RGD:30309911
Biological Process	GO:0015732	prostaglandin transport	SLC22A2	IDA		Human	PMID:11907186
Biological Process	GO:0015847	putrescine transport	SLC22A2	IDA		Human	PMID:21128598
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a2	IDA		Rat	PMID:9808712\|RGD:1643123
Biological Process	GO:0006837	serotonin transport	SLC22A2	IDA		Human	PMID:16581093
Biological Process	GO:0006837	serotonin transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0006837	serotonin transport	Slc22a2	IDA		Rat	PMID:16581093\|RGD:155663558
Biological Process	GO:0006837	serotonin transport	Slc22a2	IDA		Rat	PMID:9812985\|RGD:155888554
Biological Process	GO:0051610	serotonin uptake	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0071934	thiamine transmembrane transport	SLC22A2	IDA		Human	PMID:24961373
Biological Process	GO:1901998	toxin transport	SLC22A2	IMP		Human	PMID:20477935
Biological Process	GO:1901998	toxin transport	SLC22A2	IDA		Human	PMID:22806583
Biological Process	GO:1901998	toxin transport	SLC22A2	IDA		Human	PMID:24291757
Biological Process	GO:1901998	toxin transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:1901998	toxin transport	Slc22a2	IMP		Mouse	MGI:MGI:6436440\|PMID:20477935
Biological Process	GO:1901998	toxin transport	Slc22a2	IMP		Rat	PMID:20477935\|RGD:30309941
Biological Process	GO:1901998	toxin transport	Slc22a2	IDA		Rat	PMID:20924140\|RGD:30309940
Biological Process	GO:0042908	xenobiotic transport	SLC22A2	IMP		Human	PMID:20477935
Biological Process	GO:0042908	xenobiotic transport	SLC22A2	IDA		Human	PMID:22806583
Biological Process	GO:0042908	xenobiotic transport	SLC22A2	IDA		Human	PMID:24291757
Biological Process	GO:0042908	xenobiotic transport	SLC22A2	IDA		Human	PMID:9687576
Biological Process	GO:0042908	xenobiotic transport	Slc22a2	IMP		Mouse	MGI:MGI:6436440\|PMID:20477935
Biological Process	GO:0042908	xenobiotic transport	Slc22a2	IMP		Rat	PMID:20477935\|RGD:30309941
Biological Process	GO:0042908	xenobiotic transport	Slc22a2	IDA		Rat	PMID:20924140\|RGD:30309940

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.