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Slc22a2
Gene Detail
Symbol

Name
ID
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
MGI:1335072
Synonyms
MGC:18339, Oct2, Orct2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:12584189-12628465 bp, + strand
From Ensembl annotation of GRCm38

  44277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC22A2
Gene Tree: Slc22a2

Human
homologs
SLC22A2, solute carrier family 22 (organic cation transporter), member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6582
neXtProt AC: NX_O15244

Human Synonyms: OCT2

Human Chr (Location): 6q25.3; chr6:160216762-160258931 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knockout allele are viable and fertile and display no obvious phenotypic abnormalities. No significant defects in the renal secretion of a model organic cation are observed.
 
Interactions
Slc22a2 interacts with 88 markers (Mir7-1, Mir29b-2, Mir92-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (208)    Tissues (151)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 192
Northern blot 2
RT-PCR 12
RNase protection 2
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc22a2 ; ZFIN slc22a2    NEW 
Molecular
reagents
All nucleic(38) Genomic(6) cDNA(27) Primer pair(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000040966 (Evidence)
Entrez Gene 20518 (Evidence)
UniGene 17322
DFCI TC1583143, TC1596092
DoTS DT.91307542, DT.483072
Consensus CDS Project CCDS28392.1
International Mouse Phenotyping Consortium Status Slc22a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040966 Ensembl Gene Model | MGI Sequence Detail 44277 C57BL/6J ±  kb
transcript ENSMUST00000046959 Ensembl | MGI Sequence Detail 2115 Not Applicable 
polypeptide ENSMUSP00000041186 Ensembl | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004749 Organic cation transport protein
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000014988 solute carrier family 22 member 2
References
(Earliest) J:47780 Koehler MR, et al., The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. Cytogenet Cell Genet. 1997;79(3-4):198-200
(Latest) J:220967 Pabla N, et al., Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5231-6
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory