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Slc22a2 Gene Detail
Summary
  • Symbol
    Slc22a2
  • Name
    solute carrier family 22 (organic cation transporter), member 2
  • Synonyms
    MGC:18339, Oct2, Orct2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335072
    NCBI Gene: 20518
  • Gene Overview
    MyGene.info: SLC22A2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:12584189-12628465 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.61 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335072
protein coding gene Chr17:12583958-12628488 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023147
protein coding gene Chr17:10249538-10292838 (+)
A/J MGP_AJ_G0023115
protein coding gene Chr17:10076324-10120553 (+)
AKR/J MGP_AKRJ_G0023079
protein coding gene Chr17:9904873-9947618 (+)
BALB/cJ MGP_BALBcJ_G0023115
protein coding gene Chr17:9849446-9892757 (+)
C3H/HeJ MGP_C3HHeJ_G0022878
protein coding gene Chr17:10150664-10192307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023558
protein coding gene Chr17:10630169-10676175 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021050
protein coding gene Chr17:4326337-4378754 (-)
CAST/EiJ MGP_CASTEiJ_G0022392
protein coding gene Chr17:10226942-10272506 (+)
CBA/J MGP_CBAJ_G0022850
protein coding gene Chr17:11021646-11075130 (+)
DBA/2J MGP_DBA2J_G0022983
protein coding gene Chr17:9704117-9755482 (+)
FVB/NJ MGP_FVBNJ_G0022953
protein coding gene Chr17:9653170-9695797 (+)
LP/J MGP_LPJ_G0023055
protein coding gene Chr17:10058029-10100626 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022972
protein coding gene Chr17:10635493-10685513 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023584
protein coding gene Chr17:10166992-10213678 (+)
PWK/PhJ MGP_PWKPhJ_G0022140
protein coding gene Chr17:9405905-9451027 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021970
protein coding gene Chr17:9592532-9635237 (+)
WSB/EiJ MGP_WSBEiJ_G0022449
protein coding gene Chr17:10487639-10533899 (+)



Homology
more
  • Human Ortholog
    SLC22A2, solute carrier family 22 member 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC22A2, solute carrier family 22 member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OCT2
  • Links
    NCBI Gene ID: 6582
    neXtProt AC: NX_O15244
    UniProt: O15244

  • Chr Location
    6q25.3; chr6:160216762-160258931 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Mice homozygous for a knockout allele are viable and fertile and display no obvious phenotypic abnormalities. No significant defects in the renal secretion of a model organic cation are observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040966 Ensembl Gene Model | MGI Sequence Detail 44277 C57BL/6J ±  kb
transcript ENSMUST00000046959 Ensembl | MGI Sequence Detail 2195 Not Applicable  
polypeptide ENSMUSP00000041186 Ensembl | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 39
    Genomic 6
    cDNA 28
    Primer pair 5

    Microarray probesets 3
References
more
  • Summaries
    All 50
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:47780 Koehler MR, et al., The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. Cytogenet Cell Genet. 1997;79(3-4):198-200
  • Latest
    J:236752 Sprowl JA, et al., A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16;7:10880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory