Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc18a2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC18A2
- Mouse genes Slc18a2
- Rat genes Slc18a2
- Zfish genes slc18a2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc18a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005275	amine transmembrane transporter activity	Slc18a2	IDA		Rat	PMID:1505023\|RGD:729674
Molecular Function	GO:0019899	enzyme binding	Slc18a2	IPI	RGD:2494	Rat	PMID:19903816\|RGD:5128868
Molecular Function	GO:0019899	enzyme binding	Slc18a2	IPI	RGD:3853	Rat	PMID:19903816\|RGD:5128868
Molecular Function	GO:0031072	heat shock protein binding	Slc18a2	IPI	RGD:621725	Rat	PMID:19457116\|RGD:5130974
Molecular Function	GO:1901363	heterocyclic compound binding	Slc18a2	IPI	CHEBI:9467\|CHEBI:28790	Rat	PMID:20007701\|RGD:5130957
Molecular Function	GO:0015311	monoamine:proton antiporter activity	SLC18A2	IDA		Human	PMID:23363473
Molecular Function	GO:0015311	monoamine:proton antiporter activity	SLC18A2	IDA		Human	PMID:8643547
Molecular Function	GO:0015311	monoamine:proton antiporter activity	SLC18A2	IDA		Human	PMID:8860238
Molecular Function	GO:0015311	monoamine:proton antiporter activity	Slc18a2	IDA		Rat	PMID:25355561\|RGD:155230738
Molecular Function	GO:0015311	monoamine:proton antiporter activity	Slc18a2	IDA		Rat	PMID:8125935\|RGD:155663520
Molecular Function	GO:0015311	monoamine:proton antiporter activity	Slc18a2	IDA		Rat	PMID:8860238\|RGD:155663540
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:P25025	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q16617	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q6N075	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q6PL45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q8TDV0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q96B49	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q96DZ9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q9BVC6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A2	IPI	UniProtKB:Q9BXR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Slc18a2	IPI	UniProtKB:Q8R191	Mouse	MGI:MGI:3840716\|PMID:19357284
Cellular Component	GO:0030424	axon	Slc18a2	IDA		Rat	PMID:16301178\|RGD:155663549
Cellular Component	GO:0043679	axon terminus	Slc18a2	IDA		Rat	PMID:18973576\|RGD:2317336
Cellular Component	GO:0044297	cell body	Slc18a2	IDA		Rat	PMID:18973576\|RGD:2317336
Cellular Component	GO:0042995	cell projection	Slc18a2	IDA		Rat	PMID:21342027\|RGD:5130775
Cellular Component	GO:0005813	centrosome	SLC18A2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	Slc18a2	IDA		Rat	PMID:19457116\|RGD:5130974
Cellular Component	GO:0030425	dendrite	Slc18a2	IDA		Rat	PMID:16301178\|RGD:155663549
Cellular Component	GO:0031045	dense core granule	Slc18a2	IDA		Rat	PMID:7568015\|RGD:2317337
Cellular Component	GO:0098691	dopaminergic synapse	Slc18a2	IDA		Mouse	PMID:9427251
Cellular Component	GO:0098691	dopaminergic synapse	Slc18a2	IMP		Mouse	PMID:9427251
Cellular Component	GO:0098691	dopaminergic synapse	Slc18a2	IDA		Rat	PMID:8753875\|RGD:13702244
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SLC18A2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Slc18a2	IDA		Rat	PMID:20007701\|RGD:5130957
Cellular Component	GO:0043005	neuron projection	Slc18a2	IDA		Rat	PMID:19457116\|RGD:5130974
Cellular Component	GO:0043025	neuronal cell body	Slc18a2	IDA		Rat	PMID:19457116\|RGD:5130974
Cellular Component	GO:0098992	neuronal dense core vesicle	Slc18a2	IDA		Rat	PMID:8753875\|RGD:13702244
Cellular Component	GO:0099012	neuronal dense core vesicle membrane	Slc18a2	IDA		Rat	PMID:7568015\|RGD:2317337
Cellular Component	GO:0098794	postsynapse	Slc18a2	IDA		Rat	PMID:8753875\|RGD:13702244
Cellular Component	GO:0030667	secretory granule membrane	Slc18a2	IDA		Rat	PMID:16301178\|RGD:155663549
Cellular Component	GO:0008021	synaptic vesicle	Slc18a2	IDA		Rat	PMID:19903816\|RGD:5128868
Cellular Component	GO:0008021	synaptic vesicle	Slc18a2	IDA		Rat	PMID:7568015\|RGD:2317337
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc18a2	IDA		Mouse	MGI:MGI:1194523\|PMID:9427251
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc18a2	IDA		Rat	PMID:8753875\|RGD:13702244
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc18a2	IDA		Rat	PMID:16301178\|RGD:155663549
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc18a2	IDA		Rat	PMID:19038779\|RGD:5130996
Cellular Component	GO:0043195	terminal bouton	Slc18a2	IDA		Rat	PMID:20534840\|RGD:5130935
Biological Process	GO:0007568	aging	Slc18a2	IDA		Rat	PMID:17582657\|RGD:2317339
Biological Process	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	Slc18a2	IMP		Rat	PMID:19903816\|RGD:5128868
Biological Process	GO:0071242	cellular response to ammonium ion	Slc18a2	IEP		Rat	PMID:20534840\|RGD:5130935
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Slc18a2	IMP		Rat	PMID:20007701\|RGD:5130957
Biological Process	GO:0032456	endocytic recycling	Slc18a2	IEP		Rat	PMID:20534840\|RGD:5130935
Biological Process	GO:0042593	glucose homeostasis	Slc18a2	IDA		Rat	PMID:18577569\|RGD:2317338
Biological Process	GO:0002553	histamine secretion by mast cell	Slc18a2	IMP		Mouse	MGI:MGI:1351429\|PMID:10618388
Biological Process	GO:0051615	histamine uptake	SLC18A2	IDA		Human	PMID:8860238
Biological Process	GO:0051615	histamine uptake	Slc18a2	IDA		Rat	PMID:8860238\|RGD:155663540
Biological Process	GO:0030073	insulin secretion	Slc18a2	IDA		Rat	PMID:18577569\|RGD:2317338
Biological Process	GO:0007626	locomotory behavior	Slc18a2	IMP	MGI:MGI:3620458	Mouse	PMID:9275230
Biological Process	GO:0015844	monoamine transport	Slc18a2	IDA		Rat	PMID:1438304\|RGD:729773
Biological Process	GO:0051589	negative regulation of neurotransmitter transport	Slc18a2	IMP		Rat	PMID:16926160\|RGD:5130998
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	Slc18a2	IMP		Mouse	PMID:9427251
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	Slc18a2	IDA		Mouse	PMID:9427251
Biological Process	GO:0006836	neurotransmitter transport	Slc18a2	IDA		Rat	PMID:19008227\|RGD:5131091
Biological Process	GO:0009791	post-embryonic development	Slc18a2	IMP	MGI:MGI:3620458	Mouse	PMID:9275230
Biological Process	GO:0001975	response to amphetamine	Slc18a2	IMP	MGI:MGI:3620458	Mouse	PMID:9275230
Biological Process	GO:0001975	response to amphetamine	Slc18a2	IEP		Rat	PMID:21159748\|RGD:5130776
Biological Process	GO:0042220	response to cocaine	Slc18a2	IEP		Rat	PMID:19038779\|RGD:5130996
Biological Process	GO:0051412	response to corticosterone	Slc18a2	IEP		Rat	PMID:19494803\|RGD:5130973
Biological Process	GO:0009635	response to herbicide	Slc18a2	IEP		Rat	PMID:20553223\|RGD:5130934
Biological Process	GO:0010038	response to metal ion	Slc18a2	IEP		Rat	PMID:20224926\|RGD:5130952
Biological Process	GO:0042594	response to starvation	Slc18a2	IEP		Rat	PMID:17536021\|RGD:5131180
Biological Process	GO:0009636	response to toxic substance	Slc18a2	IMP	MGI:MGI:3620458	Mouse	PMID:9275230
Biological Process	GO:0009410	response to xenobiotic stimulus	Slc18a2	IEP		Rat	PMID:18992277\|RGD:5131093
Biological Process	GO:0010043	response to zinc ion	Slc18a2	IEP		Rat	PMID:20553223\|RGD:5130934
Biological Process	GO:0002552	serotonin secretion by mast cell	Slc18a2	IMP		Mouse	MGI:MGI:1351429\|PMID:10618388
Biological Process	GO:0051610	serotonin uptake	SLC18A2	IDA		Human	PMID:23363473
Biological Process	GO:0051610	serotonin uptake	SLC18A2	IDA		Human	PMID:8643547
Biological Process	GO:0051610	serotonin uptake	Slc18a2	IMP		Rat	PMID:20007701\|RGD:5130957
Biological Process	GO:0051610	serotonin uptake	Slc18a2	IDA		Rat	PMID:25355561\|RGD:155230738
Biological Process	GO:0051610	serotonin uptake	Slc18a2	IDA		Rat	PMID:8125935\|RGD:155663520
Biological Process	GO:0099123	somato-dendritic dopamine secretion	Slc18a2	IDA		Rat	PMID:16301178\|RGD:155663549
Biological Process	GO:0036269	swimming behavior	slc18a2	IMP	ZFIN:ZDB-GENO-170518-6	Zfish	PMID:26801555
Biological Process	GO:0036269	swimming behavior	slc18a2	IMP	ZFIN:ZDB-GENO-170518-5	Zfish	PMID:26801555

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.