About   Help   FAQ
Slc18a2
Gene Detail
Symbol

Name
ID
Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
MGI:106677
Synonyms
1110037L13Rik, Vmat2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
54.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:59260878-59296012 bp, + strand
From Ensembl annotation of GRCm38

  35135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC18A2
Protein SuperFamily: synaptic vesicle amine transporter
Gene Tree: Slc18a2

Human
homologs
SLC18A2, solute carrier family 18 (vesicular monoamine transporter), member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6571
neXtProt AC: NX_Q05940

Human Synonyms: SVAT, SVMT, VAT2, VMAT2

Human Chr (Location): 10q25; chr10:117241073-117279430 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice exhibit early postnatal death accompanied by reduced body size, hypokinesia, and reduced brain monoamine levels. Hypomorphic mutants show impaired olfaction, gastroparesis, altered sleep latency, neuron degeneration, enhanced MPTP sensitivity, anxiety- and depressive-like behavior.
 
Interactions
Slc18a2 interacts with 335 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process aging, ammonium transmembrane transport, ...
Component axon terminus, cell body, ...
Function amine transmembrane transporter activity, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (113)    Tissues (106)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 100
Western blot 4
RT-PCR 7
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN slc18a2    NEW 
Molecular
reagents
All nucleic(24) Genomic(5) cDNA(16) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000025094 (Evidence)
Entrez Gene 214084 (Evidence)
Consensus CDS Project CCDS29935.1
International Mouse Phenotyping Consortium Status Slc18a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025094 Ensembl Gene Model | MGI Sequence Detail 35135 C57BL/6J ±  kb
transcript ENSMUST00000026084 Ensembl | MGI Sequence Detail 3803 Not Applicable 
polypeptide ENSMUSP00000026084 Ensembl | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(3) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004734 Multidrug resistance protein
Protein Ontology PR:000014967 synaptic vesicular amine transporter
References
(Earliest) J:33165 Roghani A, et al., Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis. Mamm Genome. 1996 May;7(5):393-4
(Latest) J:220591 Kim JY, et al., Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. Mol Brain. 2014;7:48
All references(101)
Other
accession IDs
MGD-MRK-35136, MGI:1916004

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory