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Slc18a2
Gene Detail
Symbol

Name
ID
Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
MGI:106677
Synonyms
1110037L13Rik, Vmat2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
54.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:59260878-59296012 bp, + strand
From NCBI annotation of GRCm38

  35135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: synaptic vesicle amine transporter
Gene Tree: Slc18a2

Human
homologs
Human Homolog SLC18A2, solute carrier family 18 (vesicular monoamine transporter), member 2
NCBI Gene ID 6571
neXtProt AC  NX_Q05940
Human Synonyms  SVAT, SVMT, VAT2, VMAT2
Human Chr (Location)  10q25; chr10:117241073-117279430 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice exhibit early postnatal death accompanied by reduced body size, hypokinesia, and reduced brain monoamine levels. Hypomorphic mutants show impaired olfaction, gastroparesis, altered sleep latency, neuron degeneration, enhanced MPTP sensitivity, anxiety- and depressive-like behavior.
 
Interactions
Slc18a2 interacts with 335 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process aging, cation transmembrane transport, ...
Component axon terminus, cell body, ...
Function amine transmembrane transporter activity, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (113)    Tissues (106)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 100
Western blot 4
RT-PCR 7
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(5) cDNA(16) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000025094 (Evidence)
Entrez Gene214084 (Evidence)
Consensus CDS ProjectCCDS29935.1
International Mouse Knockout Project StatusSlc18a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 214084 NCBI Gene Model | MGI Sequence Detail 35135 C57BL/6J ±  kb
transcript NM_172523 RefSeq | MGI Sequence Detail 3803 C57BL/6 
polypeptide Q8BRU6 UniProt | EBI | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(3) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004734 Multidrug resistance protein
Protein Ontology PR:000014967 synaptic vesicular amine transporter
Graphical View of Protein Domain Structure
References
(Earliest) J:33165 Roghani A, et al., Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis. Mamm Genome. 1996 May;7(5):393-4
(Latest) J:212154 Lohr KM, et al., Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9977-82
All references(99)
Other
accession IDs
MGD-MRK-35136, MGI:1916004

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory