Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc12a5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC12A5
- Mouse genes Slc12a5
- Rat genes Slc12a5
- Zfish genes slc12a5a,slc12a5b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc12a5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	Slc12a5	IDA		Rat	PMID:15175220\|RGD:2303821
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	Slc12a5	IDA		Rat	PMID:16420452\|RGD:2303953
Molecular Function	GO:0015108	chloride transmembrane transporter activity	SLC12A5	IDA		Human	PMID:26333769
Molecular Function	GO:0015379	potassium:chloride symporter activity	SLC12A5	IDA		Human	PMID:12106695
Molecular Function	GO:0015379	potassium:chloride symporter activity	Slc12a5	IMP	MGI:MGI:2181025	Mouse	PMID:11395011
Molecular Function	GO:0015379	potassium:chloride symporter activity	Slc12a5	IDA		Rat	PMID:10942735\|RGD:2303818
Molecular Function	GO:0015379	potassium:chloride symporter activity	Slc12a5	IDA		Rat	PMID:11551954\|RGD:153298944
Molecular Function	GO:0015379	potassium:chloride symporter activity	Slc12a5	IDA		Rat	PMID:12040048\|RGD:628350
Molecular Function	GO:0015379	potassium:chloride symporter activity	Slc12a5	IDA		Rat	PMID:15175220\|RGD:2303821
Molecular Function	GO:0015379	potassium:chloride symporter activity	Slc12a5	IDA		Rat	PMID:9374636\|RGD:2303952
Molecular Function	GO:0005515	protein binding	Slc12a5	IPI	RGD:2357	Rat	PMID:15094054\|RGD:1598444
Molecular Function	GO:0005515	protein binding	Slc12a5	IPI	UniProtKB:Q7TPH6	Rat	PMID:18769030\|RGD:8553981
Cellular Component	GO:0071944	cell periphery	SLC12A5	IDA		Human	PMID:16227993
Cellular Component	GO:0071944	cell periphery	Slc12a5	IDA		Mouse	MGI:MGI:5629870\|PMID:25716834
Cellular Component	GO:0032590	dendrite membrane	Slc12a5	IDA		Rat	PMID:12967985\|RGD:2303820
Cellular Component	GO:0016020	membrane	SLC12A5	IDA		Human	PMID:12106695
Cellular Component	GO:0043005	neuron projection	SLC12A5	IDA		Human	PMID:16227993
Cellular Component	GO:0043025	neuronal cell body	SLC12A5	IDA		Human	PMID:16227993
Cellular Component	GO:0043025	neuronal cell body	Slc12a5	IDA		Mouse	MGI:MGI:5629870\|PMID:25716834
Cellular Component	GO:0043204	perikaryon	Slc12a5	IDA		Rat	PMID:12967985\|RGD:2303820
Cellular Component	GO:0005886	plasma membrane	Slc12a5	IDA		Mouse	PMID:11395011
Cellular Component	GO:0005886	plasma membrane	Slc12a5	IDA		Rat	PMID:10942735\|RGD:2303818
Cellular Component	GO:0005886	plasma membrane	Slc12a5	IDA		Rat	PMID:15175220\|RGD:2303821
Cellular Component	GO:0005886	plasma membrane	Slc12a5	IDA		Rat	PMID:9374636\|RGD:2303952
Biological Process	GO:0072488	ammonium transmembrane transport	Slc12a5	IDA		Rat	PMID:15175220\|RGD:2303821
Biological Process	GO:0072488	ammonium transmembrane transport	Slc12a5	IDA		Rat	PMID:16420452\|RGD:2303953
Biological Process	GO:0007268	chemical synaptic transmission	Slc12a5	IMP	MGI:MGI:2181025	Mouse	PMID:11395011
Biological Process	GO:1902476	chloride transmembrane transport	Slc12a5	IMP	MGI:MGI:2181025	Mouse	MGI:MGI:1935009\|PMID:11395011
Biological Process	GO:0006821	chloride transport	Slc12a5	IMP	MGI:MGI:2181025	Mouse	PMID:11395011
Biological Process	GO:0006821	chloride transport	Slc12a5	IDA		Rat	PMID:10942735\|RGD:2303818
Biological Process	GO:0006821	chloride transport	Slc12a5	IDA		Rat	PMID:12040048\|RGD:628350
Biological Process	GO:0006821	chloride transport	Slc12a5	IDA		Rat	PMID:15175220\|RGD:2303821
Biological Process	GO:0006821	chloride transport	Slc12a5	IDA		Rat	PMID:9374636\|RGD:2303952
Biological Process	GO:0060996	dendritic spine development	SLC12A5	IDA		Human	PMID:24668262
Biological Process	GO:0060996	dendritic spine development	Slc12a5	IDA		Rat	PMID:22345354\|RGD:10449516
Biological Process	GO:0006971	hypotonic response	SLC12A5	IDA		Human	PMID:12106695
Biological Process	GO:0030644	intracellular chloride ion homeostasis	SLC12A5	IDA		Human	PMID:26333769
Biological Process	GO:0051452	intracellular pH reduction	Slc12a5	IDA		Rat	PMID:16420452\|RGD:2303953
Biological Process	GO:0007612	learning	Slc12a5	IMP	MGI:MGI:3762883	Mouse	PMID:15813942
Biological Process	GO:0006811	monoatomic ion transport	SLC12A5	IDA		Human	PMID:12106695
Biological Process	GO:0035264	multicellular organism growth	Slc12a5	IMP	MGI:MGI:3762883	Mouse	PMID:15813942
Biological Process	GO:0048919	posterior lateral line neuromast development	slc12a5b	IMP	ZFIN:ZDB-MRPHLNO-110929-6	Zfish	PMID:23300475
Biological Process	GO:0048919	posterior lateral line neuromast development	slc12a5b	IGI	ZFIN:ZDB-MRPHLNO-110929-6,ZFIN:ZDB-MRPHLNO-130220-5	Zfish	PMID:23300475
Biological Process	GO:0071805	potassium ion transmembrane transport	Slc12a5	IMP	MGI:MGI:2181025	Mouse	MGI:MGI:1935009\|PMID:11395011
Biological Process	GO:0071805	potassium ion transmembrane transport	Slc12a5	IDA		Rat	PMID:11551954\|RGD:153298944
Biological Process	GO:0006813	potassium ion transport	Slc12a5	IDA		Rat	PMID:10942735\|RGD:2303818
Biological Process	GO:0006813	potassium ion transport	Slc12a5	IDA		Rat	PMID:15175220\|RGD:2303821
Biological Process	GO:0006813	potassium ion transport	Slc12a5	IDA		Rat	PMID:9374636\|RGD:2303952
Biological Process	GO:0009410	response to xenobiotic stimulus	Slc12a5	IMP	MGI:MGI:3762883	Mouse	PMID:15813942
Biological Process	GO:0060041	retina development in camera-type eye	slc12a5b	IMP	ZFIN:ZDB-MRPHLNO-110929-6	Zfish	PMID:20498234
Biological Process	GO:0040040	thermosensory behavior	Slc12a5	IMP	MGI:MGI:3762883	Mouse	PMID:15813942

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.