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Slc12a5
Gene Detail
 Symbol
Name
ID
Slc12a5
solute carrier family 12, member 5
MGI:1862037
Synonyms KCC2, mKIAA1176
Feature Type protein coding gene
Genetic Map
Chromosome 2
85.28 cM, cytoband G2-G3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:164960816-164999727 bp, + strand
From VEGA annotation of GRCm38

  38912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc12a5

Human
homologs
Human Homolog SLC12A5, solute carrier family 12 (potassium/chloride transporter), member 5
NCBI Gene ID 57468
neXtProt AC  NX_Q9H2X9
Human Synonyms  KCC2
Human Chr (Location)  20q13.12; chr20:46021690-46060150 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die within a few minutes of birth of respiratory failure resulting from a motor nerve defect. Mice homozygous for a hypomorphic allele display postnatal lethality and tonic-clonic seizures.
 
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process ammonium transmembrane transport, ammonium transport, ...
Component cell projection, dendrite membrane, ...
Function ammonium transmembrane transporter activity, cation:chloride symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (155)    Tissues (43)    Images (37)
Theiler Stages: 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 153
RT-PCR 2
cDNA source data(83)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(90) Genomic(5) cDNA(83) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019699 (Evidence)
Ensembl Gene ModelENSMUSG00000017740 (Evidence)
Entrez Gene57138 (Evidence)
UniGene252987
DFCITC1574615, TC1605874, TC1654271, TC1658398
DoTSDT.101122088, DT.101353454, DT.101400236, DT.110657038, DT.55204728
NIA Mouse Gene IndexU002825, U360279
Consensus CDS ProjectCCDS38332.1
International Mouse Knockout Project StatusSlc12a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019699 VEGA Gene Model | MGI Sequence Detail 38912 C57BL/6J ±  kb
transcript OTTMUST00000002164 VEGA | MGI Sequence Detail 6024 Not Applicable 
polypeptide OTTMUSP00000001056 VEGA | MGI Sequence Detail 1115 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004841 Amino acid permease domain
InterPro IPR000076 K-Cl co-transporter
InterPro IPR004842 Na/K/Cl co-transporter superfamily
Protein Ontology PR:000014928 solute carrier family 12 member 5
References (Earliest) J:63901 Haapa S, et al., An efficient DNA sequencing strategy based on the bacteriophage mu in vitro DNA transposition reaction. Genome Res. 1999 Mar;9(3):308-15
(Latest) J:198353 Shibasaki M, et al., Involvement of the K+-Cl- co-transporter KCC2 in the sensitization to morphine-induced hyperlocomotion under chronic treatment with zolpidem in the mesolimbic system. J Neurochem. 2013 Jun;125(5):747-55
All references(69)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory