Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIX6
  • Mouse genes Six6
  • Rat genes Six6
  • Zfish genes six6a,six6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Six6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003690	double-stranded DNA binding	six6b	IDA		Zfish	PMID:30765521
Molecular Function	GO:0005515	protein binding	Six6	IPI	PR:Q62441	Mouse	PMID:12050133
Molecular Function	GO:0005515	protein binding	Six6	IPI	PR:P63002	Mouse	PMID:12050133
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SIX6	IDA		Human	PMID:18836447
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Six6	IDA		Mouse	PMID:18836447
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SIX6	IDA		Human	PMID:28473536
Biological Process	GO:0043010	camera-type eye development	six6b	IMP	ZFIN:ZDB-MRPHLNO-140310-2	Zfish	PMID:24150847
Biological Process	GO:0008283	cell population proliferation	six6b	IMP	ZFIN:ZDB-MRPHLNO-140310-2	Zfish	PMID:24150847
Biological Process	GO:0001654	eye development	six6b	IMP	ZFIN:ZDB-MRPHLNO-140310-2	Zfish	PMID:28073927
Biological Process	GO:0010467	gene expression	six6b	IGI	ZFIN:ZDB-GENO-201007-3	Zfish	PMID:30765521
Biological Process	GO:0010467	gene expression	six6b	IGI	ZFIN:ZDB-GENE-990825-28	Zfish	PMID:30765521
Biological Process	GO:0010467	gene expression	six6a	IGI	ZFIN:ZDB-GENO-201006-7	Zfish	PMID:30765521
Biological Process	GO:0010467	gene expression	six6a	IGI	ZFIN:ZDB-GENO-201007-3	Zfish	PMID:30765521
Biological Process	GO:0003407	neural retina development	six6a	IMP	ZFIN:ZDB-MRPHLNO-140903-2	Zfish	PMID:24875647

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern