Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SFRP4
  • Mouse genes Sfrp4
  • Rat genes Sfrp4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sfrp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SFRP4	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:15607035
Molecular Function	GO:0005515	protein binding	SFRP4	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SFRP4	IPI	UniProtKB:Q8NBQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SFRP4	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0017147	Wnt-protein binding	SFRP4	IDA		Human	PMID:17462603
Molecular Function	GO:0017147	Wnt-protein binding	SFRP4	IPI	UniProtKB:P27467	Human	PMID:17462603
Molecular Function	GO:0017147	Wnt-protein binding	Sfrp4	IPI	RGD:69079	Rat	PMID:18567805|RGD:4107045
Cellular Component	GO:0009986	cell surface	SFRP4	IDA		Human	PMID:14760084
Cellular Component	GO:0005737	cytoplasm	SFRP4	IDA		Human	PMID:11793365
Cellular Component	GO:0005737	cytoplasm	SFRP4	IDA		Human	PMID:14760084
Cellular Component	GO:0005737	cytoplasm	SFRP4	IDA		Human	PMID:18938133
Cellular Component	GO:0005737	cytoplasm	Sfrp4	IDA		Rat	PMID:12960062|RGD:4107072
Cellular Component	GO:0005615	extracellular space	SFRP4	IDA		Human	PMID:14760084
Cellular Component	GO:0005615	extracellular space	Sfrp4	IDA		Rat	PMID:12960062|RGD:4107072
Cellular Component	GO:0005634	nucleus	SFRP4	IDA		Human	PMID:18938133
Biological Process	GO:0060349	bone morphogenesis	SFRP4	IMP		Human	PMID:27355534
Biological Process	GO:0060349	bone morphogenesis	Sfrp4	IMP		Mouse	MGI:MGI:5790095|PMID:27355534
Biological Process	GO:0046697	decidualization	Sfrp4	IEP		Rat	PMID:12063187|RGD:633927
Biological Process	GO:0007565	female pregnancy	Sfrp4	IEP		Rat	PMID:16540541|RGD:4107722
Biological Process	GO:0060056	mammary gland involution	Sfrp4	IEP		Rat	PMID:9409757|RGD:4107723
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SFRP4	IMP		Human	PMID:14760084
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SFRP4	IMP		Human	PMID:15705870
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SFRP4	IDA		Human	PMID:18945944
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp4	IMP		Mouse	MGI:MGI:5790095|PMID:27355534
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp4	IDA		Rat	PMID:12952927|RGD:8554482
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp4	IDA		Rat	PMID:18567805|RGD:4107045
Biological Process	GO:0008285	negative regulation of cell population proliferation	SFRP4	IMP		Human	PMID:14760084
Biological Process	GO:0008285	negative regulation of cell population proliferation	SFRP4	IMP		Human	PMID:15705870
Biological Process	GO:0008285	negative regulation of cell population proliferation	Sfrp4	IDA		Rat	PMID:18567805|RGD:4107045
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	SFRP4	IDA		Human	PMID:18945944
Biological Process	GO:0046329	negative regulation of JNK cascade	Sfrp4	IDA		Rat	PMID:18567805|RGD:4107045
Biological Process	GO:2000051	negative regulation of non-canonical Wnt signaling pathway	Sfrp4	IMP		Mouse	MGI:MGI:5790095|PMID:27355534
Biological Process	GO:2000119	negative regulation of sodium-dependent phosphate transport	SFRP4	IDA		Human	PMID:12952927
Biological Process	GO:2000119	negative regulation of sodium-dependent phosphate transport	SFRP4	IDA		Human	PMID:16151791
Biological Process	GO:0055062	phosphate ion homeostasis	SFRP4	IDA		Human	PMID:12952927
Biological Process	GO:0055062	phosphate ion homeostasis	SFRP4	IDA		Human	PMID:16151791
Biological Process	GO:0043065	positive regulation of apoptotic process	SFRP4	IMP		Human	PMID:15705870
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	SFRP4	IGI	UniProtKB:P27467	Human	PMID:18166153
Biological Process	GO:0045606	positive regulation of epidermal cell differentiation	SFRP4	IDA		Human	PMID:18938133
Biological Process	GO:0010628	positive regulation of gene expression	SFRP4	IDA		Human	PMID:18938133
Biological Process	GO:1902174	positive regulation of keratinocyte apoptotic process	SFRP4	IDA		Human	PMID:18938133
Biological Process	GO:0002092	positive regulation of receptor internalization	SFRP4	IDA		Human	PMID:16151791
Biological Process	GO:0030510	regulation of BMP signaling pathway	Sfrp4	IMP		Mouse	MGI:MGI:5790095|PMID:27355534
Biological Process	GO:0032355	response to estradiol	Sfrp4	IEP		Rat	PMID:12063187|RGD:633927
Biological Process	GO:0051384	response to glucocorticoid	Sfrp4	IEP		Rat	PMID:16540541|RGD:4107722
Biological Process	GO:0043434	response to peptide hormone	Sfrp4	IEP		Rat	PMID:12960062|RGD:4107072

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern