Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SETD1A
  • Mouse genes Setd1a
  • Rat genes Setd1a
  • Zfish genes setd1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Setd1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	SETD1A	IPI	UniProtKB:Q02248	Human	PMID:22723415
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	SETD1A	IDA		Human	PMID:20862685
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Setd1a	IMP		Mouse	MGI:MGI:6189337|PMID:29490266
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Setd1a	IMP	MGI:MGI:5568936	Mouse	PMID:24550110
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:P14859	Human	PMID:12670868
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:P51610	Human	PMID:12670868
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:P24928	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:P51610	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:P61964	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q15291	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q6UXN9	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q9P0U4	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q9UBL3	Human	PMID:17998332
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q8NI51	Human	PMID:18765639
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q9UPP1	Human	PMID:20622854
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:P61964	Human	PMID:22266653
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:P61964	Human	PMID:22665483
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q02248	Human	PMID:22723415
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q62383	Human	PMID:22843687
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q15291	Human	PMID:23870121
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q9UBL3-3	Human	PMID:26886794
Molecular Function	GO:0005515	protein binding	SETD1A	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Setd1a	IPI	UniProtKB:P28656	Mouse	MGI:MGI:6189337|PMID:29490266
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	SETD1A	IPI	UniProtKB:P22415	Human	PMID:27141965
Cellular Component	GO:0000785	chromatin	SETD1A	IDA		Human	PMID:27141965
Cellular Component	GO:0000791	euchromatin	Setd1a	IDA		Mouse	MGI:MGI:5428344|PMID:22723415
Cellular Component	GO:0035097	histone methyltransferase complex	SETD1A	IDA		Human	PMID:17355966
Cellular Component	GO:0035097	histone methyltransferase complex	SETD1A	IDA		Human	PMID:17500065
Cellular Component	GO:0016607	nuclear speck	SETD1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SETD1A	IDA		Human	PMID:17500065
Cellular Component	GO:0005634	nucleus	SETD1A	IMP		Human	PMID:22723415
Cellular Component	GO:0005634	nucleus	Setd1a	IDA		Mouse	PMID:24550110
Cellular Component	GO:0048188	Set1C/COMPASS complex	SETD1A	IPI		Human	PMID:23508102
Cellular Component	GO:0048188	Set1C/COMPASS complex	SETD1A	IDA		Human	PMID:17998332
Cellular Component	GO:0048188	Set1C/COMPASS complex	SETD1A	IDA		Human	PMID:18838538
Biological Process	GO:0007420	brain development	SETD1A	IMP		Human	PMID:31197650
Biological Process	GO:0007420	brain development	Setd1a	IMP		Mouse	MGI:MGI:6467717|PMID:31197650
Biological Process	GO:0010628	positive regulation of gene expression	Setd1a	IMP		Mouse	MGI:MGI:5816640|PMID:27141965
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Setd1a	IMP	MGI:MGI:5568941	Mouse	PMID:24550110
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Setd1a	IMP	MGI:MGI:5568941	Mouse	PMID:24550110
Biological Process	GO:1902275	regulation of chromatin organization	SETD1A	IDA		Human	PMID:27141965
Biological Process	GO:1902275	regulation of chromatin organization	Setd1a	IDA		Mouse	MGI:MGI:5816640|PMID:27141965
Biological Process	GO:0045646	regulation of erythrocyte differentiation	Setd1a	IMP		Mouse	MGI:MGI:5816640|PMID:27141965
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	SETD1A	IDA		Human	PMID:27141965
Biological Process	GO:0019827	stem cell population maintenance	Setd1a	IMP	MGI:MGI:5568941	Mouse	PMID:24550110
Biological Process	GO:0072089	stem cell proliferation	Setd1a	IMP	MGI:MGI:5568941	Mouse	PMID:24550110

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern