Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SEPTIN4
  • Mouse genes Septin4
  • Rat genes Septin4
  • Zfish genes septin4a,septin4b,zgc:162239
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Septin4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005525	GTP binding	SEPTIN4	IMP		Human	PMID:17105210
Molecular Function	GO:0003924	GTPase activity	SEPTIN4	IMP		Human	PMID:17105210
Molecular Function	GO:0042802	identical protein binding	SEPTIN4	IPI	UniProtKB:O43236	Human	PMID:17105210
Molecular Function	GO:0000287	magnesium ion binding	SEPTIN4	IMP		Human	PMID:17105210
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:Q4V8G5	Human	PMID:17685441
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:P98170	Human	PMID:21695558
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:O15033,UniProtKB:O43464,UniProtKB:Q9NR28	Human	PMID:23479728
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:Q8IYM1	Human	PMID:25588830
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:Q8IYM1	Human	PMID:25775403
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:P10415,UniProtKB:P98170	Human	PMID:29020630
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:P63167	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:Q96FJ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SEPTIN4	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Septin4	IPI	UniProtKB:O35526|UniProtKB:O55042|UniProtKB:Q61327	Mouse	MGI:MGI:3796969|PMID:17296554
Molecular Function	GO:0005515	protein binding	Septin4	IPI	UniProtKB:Q9Z2Q6	Mouse	MGI:MGI:3822234|PMID:18809578
Molecular Function	GO:0005515	protein binding	Septin4	IPI	UniProtKB:Q9DA97	Mouse	MGI:MGI:6717245|PMID:20181826
Molecular Function	GO:0005515	protein binding	Septin4	IPI	UniProtKB:Q8CHG5,UniProtKB:Q9JIQ3,UniProtKB:Q9JIY5	Mouse	MGI:MGI:5498443|PMID:23479728
Molecular Function	GO:0005515	protein binding	Septin4	IPI	UniProtKB:Q60989	Mouse	MGI:MGI:6268242|PMID:30389919
Cellular Component	GO:0030424	axon	Septin4	IDA		Mouse	MGI:MGI:6717245|PMID:20181826
Cellular Component	GO:0043679	axon terminus	Septin4	IDA		Mouse	MGI:MGI:3796969|PMID:17296554
Cellular Component	GO:0042995	cell projection	Septin4	IDA		Mouse	PMID:11064363
Cellular Component	GO:0005737	cytoplasm	Septin4	IDA		Mouse	MGI:MGI:6717245|PMID:20181826
Cellular Component	GO:0030425	dendrite	Septin4	IDA		Mouse	MGI:MGI:6717245|PMID:20181826
Cellular Component	GO:0005739	mitochondrion	SEPTIN4	IDA		Human	PMID:21695558
Cellular Component	GO:0005739	mitochondrion	Septin4	HDA		Mouse	PMID:18614015
Cellular Component	GO:0031514	motile cilium	Septin4	IMP	MGI:MGI:3574368	Mouse	PMID:15737931
Cellular Component	GO:0043209	myelin sheath	Septin4	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005654	nucleoplasm	SEPTIN4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043204	perikaryon	Septin4	IDA		Mouse	MGI:MGI:6717245|PMID:20181826
Cellular Component	GO:0031105	septin complex	SEPTIN4	IMP		Human	PMID:17105210
Cellular Component	GO:0031105	septin complex	SEPTIN4	IDA		Human	PMID:25588830
Cellular Component	GO:0031105	septin complex	Septin4	IDA		Mouse	MGI:MGI:3822234|PMID:18809578
Cellular Component	GO:0097227	sperm annulus	SEPTIN4	IDA		Human	PMID:25588830
Cellular Component	GO:0097227	sperm annulus	Septin4	IDA		Mouse	MGI:MGI:3531235|PMID:15737930
Cellular Component	GO:0097227	sperm annulus	Septin4	IDA		Mouse	MGI:MGI:3531234|PMID:15737931
Cellular Component	GO:0097227	sperm annulus	Septin4	IDA		Mouse	PMID:23976951
Cellular Component	GO:0036126	sperm flagellum	Septin4	IDA		Mouse	PMID:23976951
Biological Process	GO:0007420	brain development	Septin4	IMP	MGI:MGI:3574373	Mouse	PMID:16314519
Biological Process	GO:0030317	flagellated sperm motility	Septin4	IMP		Mouse	MGI:MGI:3531234|PMID:15737931
Biological Process	GO:0030317	flagellated sperm motility	Septin4	IMP		Mouse	MGI:MGI:3531235|PMID:15737930
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Septin4	IMP		Mouse	MGI:MGI:4836271|PMID:20952537
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Septin4	IMP		Mouse	MGI:MGI:6268242|PMID:30389919
Biological Process	GO:0001764	neuron migration	Septin4	IMP		Mouse	MGI:MGI:6717245|PMID:20181826
Biological Process	GO:0043065	positive regulation of apoptotic process	SEPTIN4	IDA		Human	PMID:21185211
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	SEPTIN4	IMP		Human	PMID:21185211
Biological Process	GO:0031398	positive regulation of protein ubiquitination	SEPTIN4	IDA		Human	PMID:21185211
Biological Process	GO:0048240	sperm capacitation	Septin4	IMP	MGI:MGI:3574368	Mouse	PMID:15737931
Biological Process	GO:0030382	sperm mitochondrion organization	Septin4	IMP	MGI:MGI:3574368	Mouse	PMID:15737931
Biological Process	GO:0007286	spermatid development	Septin4	IMP	MGI:MGI:3574368	Mouse	PMID:15737931
Biological Process	GO:0048515	spermatid differentiation	Septin4	IMP		Mouse	MGI:MGI:3531234|PMID:15737931
Biological Process	GO:0048729	tissue morphogenesis	Septin4	IMP		Mouse	MGI:MGI:6268242|PMID:30389919

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern