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Sept4
Gene Detail
Symbol

Name
ID
Sept4
septin 4
MGI:1270156
Synonyms
ARTS, Bh5, cell division control-related protein 2b, Pnutl2, septin H5
Feature Type
protein coding gene
Genetic Map
Chromosome 11
52.14 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:87568903-87590539 bp, + strand
From VEGA annotation of GRCm38

  21637 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6107  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: septin
Gene Tree: Sept4

Human
homologs
Human Homolog SEPT4, septin 4
NCBI Gene ID 5414
neXtProt AC  NX_O43236
Human Synonyms  ARTS, BRADEION, CE5B3, H5, hCDCREL-2, MART, PNUTL2, SEP4
Human Chr (Location)  17q22; chr17:58520250-58540818 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null males are sterile and have immotile and structurally defective sperm that is bent and lacks the annulus.
 
Interactions
Sept4 interacts with 58 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process brain development, cell cycle, ...
Component cell projection, cytoplasm, ...
Function GTP binding, nucleotide binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (79)    Tissues (51)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 79
cDNA source data(57)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(58)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001264 (Evidence)
Ensembl Gene ModelENSMUSG00000020486 (Evidence)
Entrez Gene18952 (Evidence)
UniGene2214
DFCITC1576476, TC1587750, TC1605841, TC1654863, TC1690656
DoTSDT.101386318, DT.101386322, DT.110546065, DT.481763, DT.91428473, DT.94182905, DT.94204926, DT.94204936, DT.97394479
NIA Mouse Gene IndexU013140
Consensus CDS ProjectCCDS25213.1, CCDS70275.1, CCDS70276.1, CCDS70277.1
International Mouse Knockout Project StatusSept4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001264 VEGA Gene Model | MGI Sequence Detail 21637 C57BL/6J ±  kb
transcript OTTMUST00000002519 VEGA | MGI Sequence Detail 1726 Not Applicable 
polypeptide OTTMUSP00000001240 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(134) RefSeq(48) UniProt(4)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000038 Cell division protein GTP binding
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR016491 Septin
Protein Ontology PR:000014656 septin-4
References
(Earliest) J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory