Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SDC4
  • Mouse genes Sdc4
  • Rat genes Sdc4
  • Zfish genes sdc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sdc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001968	fibronectin binding	Sdc4	IDA		Rat	PMID:11372670|RGD:2312328
Molecular Function	GO:0042802	identical protein binding	SDC4	IPI	UniProtKB:P31431	Human	PMID:18093920
Molecular Function	GO:0042802	identical protein binding	Sdc4	IPI	UniProtKB:P34901	Rat	PMID:12571249|RGD:1580031
Molecular Function	GO:0042802	identical protein binding	Sdc4	IPI	UniProtKB:P34901	Rat	PMID:26601939|RGD:13825434
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	sdc4	IDA		Zfish	PMID:18753130
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:P17252	Human	PMID:12571249
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:O75056	Human	PMID:18093920
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:P34741	Human	PMID:18093920
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:Q14956	Human	PMID:19350579
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:Q6PRD1	Human	PMID:30282023
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:Q8C419	Human	PMID:30282023
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:P16871	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:P21145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:Q01453	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SDC4	IPI	UniProtKB:P0DTC2	Human	PMID:34069441
Molecular Function	GO:0005515	protein binding	Sdc4	IPI	UniProtKB:Q15113	Mouse	MGI:MGI:5787767|PMID:25286301
Molecular Function	GO:0005515	protein binding	Sdc4	IPI	UniProtKB:P04937	Rat	PMID:10640397|RGD:8554438
Molecular Function	GO:0005515	protein binding	Sdc4	IPI	UniProtKB:P05696	Rat	PMID:12571249|RGD:1580031
Molecular Function	GO:0005515	protein binding	Sdc4	IPI	UniProtKB:P34900	Rat	PMID:26601939|RGD:13825434
Molecular Function	GO:0005080	protein kinase C binding	Sdc4	IDA		Rat	PMID:12571249|RGD:1580031
Molecular Function	GO:0070053	thrombospondin receptor activity	SDC4	IMP		Human	PMID:17879962
Cellular Component	GO:0009986	cell surface	Sdc4	IDA		Mouse	PMID:15381701
Cellular Component	GO:0009986	cell surface	Sdc4	IDA		Rat	PMID:10504291|RGD:2312327
Cellular Component	GO:0043034	costamere	Sdc4	IDA		Rat	PMID:12209563|RGD:729823
Cellular Component	GO:0070062	extracellular exosome	SDC4	HDA		Human	PMID:19199708
Cellular Component	GO:0005925	focal adhesion	Sdc4	IDA		Rat	PMID:12493766|RGD:1304266
Cellular Component	GO:0005925	focal adhesion	sdc4	IDA		Zfish	PMID:18753130
Cellular Component	GO:0045121	membrane raft	Sdc4	IDA		Rat	PMID:11889131|RGD:1580030
Biological Process	GO:0007155	cell adhesion	sdc4	IDA		Zfish	PMID:16936286
Biological Process	GO:0033627	cell adhesion mediated by integrin	sdc4	IDA		Zfish	PMID:18753130
Biological Process	GO:0016477	cell migration	sdc4	IDA		Zfish	PMID:18753130
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	sdc4	IMP	ZFIN:ZDB-MRPHLNO-120425-8	Zfish	PMID:22399807
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Sdc4	IGI	MGI:MGI:2135272	Mouse	PMID:23760952
Biological Process	GO:0042130	negative regulation of T cell proliferation	SDC4	IMP		Human	PMID:19350579
Biological Process	GO:0001843	neural tube closure	Sdc4	IGI	MGI:MGI:2135272	Mouse	PMID:23760952
Biological Process	GO:0036445	neuronal stem cell division	sdc4	IMP	ZFIN:ZDB-MRPHLNO-120425-8	Zfish	PMID:27143125
Biological Process	GO:1903543	positive regulation of exosomal secretion	SDC4	IMP		Human	PMID:22660413
Biological Process	GO:1903553	positive regulation of extracellular exosome assembly	SDC4	IMP		Human	PMID:22660413
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	Sdc4	IMP		Rat	PMID:10504291|RGD:2312327
Biological Process	GO:0045860	positive regulation of protein kinase activity	Sdc4	IMP		Rat	PMID:12571249|RGD:1580031
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Sdc4	IMP		Rat	PMID:10504291|RGD:2312327
Biological Process	GO:0010762	regulation of fibroblast migration	Sdc4	IMP		Mouse	MGI:MGI:5621257|PMID:25074804
Biological Process	GO:0043149	stress fiber assembly	sdc4	IDA		Zfish	PMID:18753130
Biological Process	GO:0001657	ureteric bud development	Sdc4	IEP		Rat	PMID:15282150|RGD:1643132
Biological Process	GO:0042060	wound healing	Sdc4	IGI	MGI:MGI:2135272	Mouse	PMID:23760952
Biological Process	GO:0042060	wound healing	sdc4	IDA		Zfish	PMID:18753130

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern