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Sdc4
Gene Detail
Symbol

Name
ID
Sdc4
syndecan 4
MGI:1349164
Synonyms
ryudocan, Synd4, syndecan-4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
85.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:164424247-164443887 bp, - strand
From VEGA annotation of GRCm38

  19641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31121  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ryudocan
Gene Tree: Sdc4

Human
homologs
Human Homolog SDC4, syndecan 4
NCBI Gene ID 6385
neXtProt AC  NX_P31431
Human Synonyms  SYND4
Human Chr (Location)  20q12; chr20:45325288-45348424 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(23) Targeted(5)
 
Mice homozygous or heterozygous for a knock-out allele show delayed wound healing and impaired angiogenesis. Homozygotes for a different knock-out allele exhibit degenerated fetal vessels in the placental labyrinth, abnormal cell adhesion, and high susceptibility to induced renal and hepatic injury.
 
Interactions
Sdc4 interacts with 194 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (252)    Tissues (67)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 243
Northern blot 1
RT-PCR 4
cDNA source data(186)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(189) cDNA(186) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001157 (Evidence)
Ensembl Gene ModelENSMUSG00000017009 (Evidence)
Entrez Gene20971 (Evidence)
UniGene3815
DFCITC1574558, TC1596910
DoTSDT.87069462, DT.94350098, DT.97413294, DT.99848354
NIA Mouse Gene IndexU023635
Consensus CDS ProjectCCDS17036.1
International Mouse Knockout Project StatusSdc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001157 VEGA Gene Model | MGI Sequence Detail 19641 C57BL/6J ±  kb
transcript OTTMUST00000002252 VEGA | MGI Sequence Detail 2458 Not Applicable 
polypeptide OTTMUSP00000001098 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003585 Neurexin/syndecan/glycophorin C
InterPro IPR001050 Syndecan
Protein Ontology PR:000014553 syndecan-4
References
(Earliest) J:23985 Baciu PC, et al., Prediction of a novel integral membrane proteoglycan core protein related to Syndecan and Fibroglycan. J Cell Biol. 1991;115:125a
(Latest) J:209924 Chung JS, et al., The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells. J Immunol. 2014 Mar 15;192(6):2576-84
All references(102)
Other
accession IDs
MGD-MRK-14689, MGI:2138809, MGI:2139303, MGI:98466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory