Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN8A
  • Mouse genes Scn8a
  • Rat genes Scn8a
  • Zfish genes scn8aa,scn8ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn8a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SCN8A	IPI	UniProtKB:Q92915-2	Human	PMID:22364545
Molecular Function	GO:0005515	protein binding	SCN8A	IPI	UniProtKB:Q92915-2	Human	PMID:25659151
Molecular Function	GO:0005515	protein binding	SCN8A	IPI	UniProtKB:P62879	Human	PMID:26900580
Molecular Function	GO:0005515	protein binding	SCN8A	IPI	UniProtKB:P63215	Human	PMID:26900580
Molecular Function	GO:0005515	protein binding	SCN8A	IPI	UniProtKB:Q07699	Human	PMID:26900580
Molecular Function	GO:0005515	protein binding	SCN8A	IPI	UniProtKB:Q92915	Human	PMID:26900580
Molecular Function	GO:0005515	protein binding	Scn8a	IPI	UniProtKB:P14873	Mouse	MGI:MGI:5487502|PMID:22474336
Molecular Function	GO:0005515	protein binding	Scn8a	IPI	UniProtKB:Q92913	Rat	PMID:15282281|RGD:8554831
Molecular Function	GO:0031402	sodium ion binding	Scn8a	IDA		Rat	PMID:15664695|RGD:1599536
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN8A	IDA		Human	PMID:21078353
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN8A	IDA		Human	PMID:25239001
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN8A	IMP		Human	PMID:25725044
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn8a	IDA		Rat	PMID:15664695|RGD:1599536
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn8a	IMP		Rat	PMID:17273863|RGD:2289022
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn8a	IDA		Rat	PMID:9603190|RGD:69984
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn8aa	IMP	ZFIN:ZDB-MRPHLNO-070117-2	Zfish	PMID:16943272
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn8aa	IDA		Zfish	PMID:20225246
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn8aa	IMP	ZFIN:ZDB-MRPHLNO-050812-4	Zfish	PMID:15673553
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn8aa	IDA		Zfish	PMID:17623064
Cellular Component	GO:0030424	axon	Scn8a	IDA		Rat	PMID:21118538|RGD:15090835
Cellular Component	GO:0043194	axon initial segment	Scn8a	IDA		Rat	PMID:11724816|RGD:8553674
Cellular Component	GO:0030054	cell junction	SCN8A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Scn8a	IDA		Mouse	PMID:17928448
Cellular Component	GO:0098978	glutamatergic synapse	Scn8a	IDA		Rat	PMID:10779552|RGD:13702270
Cellular Component	GO:0016020	membrane	Scn8a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0016020	membrane	Scn8a	IDA		Rat	PMID:9603190|RGD:69984
Cellular Component	GO:0043025	neuronal cell body	Scn8a	IDA		Mouse	PMID:17928448
Cellular Component	GO:0033268	node of Ranvier	Scn8a	IDA		Mouse	MGI:MGI:2181223|PMID:11807096
Cellular Component	GO:0033268	node of Ranvier	Scn8a	IDA		Rat	PMID:16652168|RGD:8553545
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Scn8a	IDA		Rat	PMID:10779552|RGD:13702270
Cellular Component	GO:0005886	plasma membrane	SCN8A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Scn8a	IDA		Rat	PMID:17273863|RGD:2289022
Cellular Component	GO:0098839	postsynaptic density membrane	Scn8a	IDA		Rat	PMID:10779552|RGD:13702270
Cellular Component	GO:0048787	presynaptic active zone membrane	Scn8a	IDA		Rat	PMID:10779552|RGD:13702270
Cellular Component	GO:0034706	sodium channel complex	Scn8a	IPI	PR:P97952	Mouse	PMID:15272007
Cellular Component	GO:0034706	sodium channel complex	Scn8a	IPI	UniProtKB:A2APX8	Mouse	PMID:15272007
Cellular Component	GO:0034706	sodium channel complex	Scn8a	IPI	PR:Q9JJV9	Mouse	PMID:15272007
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn8a	IDA		Rat	PMID:15664695|RGD:1599536
Cellular Component	GO:0030018	Z disc	Scn8a	IDA		Mouse	MGI:MGI:3763979|PMID:17884088
Biological Process	GO:0007628	adult walking behavior	Scn8a	IMP	MGI:MGI:1856078	Mouse	PMID:7670495
Biological Process	GO:0008345	larval locomotory behavior	scn8aa	IMP	ZFIN:ZDB-MRPHLNO-080305-6	Zfish	PMID:17687633
Biological Process	GO:0008345	larval locomotory behavior	scn8aa	IMP	ZFIN:ZDB-MRPHLNO-080305-5	Zfish	PMID:17687633
Biological Process	GO:0008345	larval locomotory behavior	scn8aa	IMP	ZFIN:ZDB-MRPHLNO-080305-4	Zfish	PMID:17687633
Biological Process	GO:0007626	locomotory behavior	Scn8a	IMP	MGI:MGI:1856079	Mouse	PMID:12920299
Biological Process	GO:0007638	mechanosensory behavior	scn8aa	IMP	ZFIN:ZDB-GENO-100726-4	Zfish	PMID:20225246
Biological Process	GO:0007638	mechanosensory behavior	scn8aa	IMP	ZFIN:ZDB-GENO-100726-3	Zfish	PMID:20225246
Biological Process	GO:0008045	motor neuron axon guidance	scn8aa	IMP	ZFIN:ZDB-MRPHLNO-050812-4	Zfish	PMID:16943272
Biological Process	GO:0007517	muscle organ development	Scn8a	IMP	MGI:MGI:2429911	Mouse	PMID:15170223
Biological Process	GO:0042552	myelination	Scn8a	IEP		Rat	PMID:16652168|RGD:8553545
Biological Process	GO:0019228	neuronal action potential	Scn8a	IDA		Rat	PMID:15664695|RGD:1599536
Biological Process	GO:0019228	neuronal action potential	Scn8a	IDA		Rat	PMID:15917456|RGD:2289019
Biological Process	GO:0019228	neuronal action potential	Scn8a	IMP		Rat	PMID:17273863|RGD:2289022
Biological Process	GO:0021554	optic nerve development	Scn8a	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0007422	peripheral nervous system development	Scn8a	IEP		Rat	PMID:16652168|RGD:8553545
Biological Process	GO:0009636	response to toxic substance	Scn8a	IDA		Mouse	PMID:16029194
Biological Process	GO:0007605	sensory perception of sound	Scn8a	IMP	MGI:MGI:1856079	Mouse	PMID:12204355
Biological Process	GO:0035725	sodium ion transmembrane transport	scn8aa	IDA		Zfish	PMID:17623064
Biological Process	GO:0006814	sodium ion transport	Scn8a	IDA		Rat	PMID:9603190|RGD:69984

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern