Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RSPO3
  • Mouse genes Rspo3
  • Rat genes Rspo3
  • Zfish genes rspo3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rspo3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	Rspo3	IPI	PR:Q61091	Mouse	PMID:16543246
Molecular Function	GO:0008201	heparin binding	Rspo3	IDA		Mouse	PMID:16543246
Molecular Function	GO:0005102	signaling receptor binding	RSPO3	IPI	UniProtKB:Q9HBX8	Human	PMID:22615920
Molecular Function	GO:0005102	signaling receptor binding	Rspo3	IPI	UniProtKB:O75581	Mouse	PMID:16543246
Cellular Component	GO:0005576	extracellular region	Rspo3	IDA		Mouse	PMID:16543246
Biological Process	GO:0060612	adipose tissue development	rspo3	IMP	ZFIN:ZDB-GENO-210819-2	Zfish	PMID:32493999
Biological Process	GO:0001525	angiogenesis	Rspo3	IMP	MGI:MGI:5609537	Mouse	PMID:18842812
Biological Process	GO:0001974	blood vessel remodeling	Rspo3	IMP		Mouse	MGI:MGI:5751613|PMID:26766444
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	Rspo3	IMP	MGI:MGI:3695687	Mouse	PMID:16963017
Biological Process	GO:0060070	canonical Wnt signaling pathway	Rspo3	IMP	MGI:MGI:5609537	Mouse	PMID:18842812
Biological Process	GO:1904888	cranial skeletal system development	rspo3	IGI	ZFIN:ZDB-GENO-221013-7,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:1904888	cranial skeletal system development	rspo3	IGI	ZFIN:ZDB-GENO-221013-6,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:1904888	cranial skeletal system development	rspo3	IMP	ZFIN:ZDB-GENO-221013-6	Zfish	PMID:33712657
Biological Process	GO:0060829	negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation	rspo3	IMP	ZFIN:ZDB-MRPHLNO-140929-7	Zfish	PMID:24918770
Biological Process	GO:0060829	negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation	rspo3	IMP	ZFIN:ZDB-MRPHLNO-140929-8	Zfish	PMID:24918770
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	rspo3	IMP	ZFIN:ZDB-MRPHLNO-140929-8	Zfish	PMID:24918770
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	rspo3	IMP	ZFIN:ZDB-MRPHLNO-140929-7	Zfish	PMID:24918770
Biological Process	GO:0033339	pectoral fin development	rspo3	IGI	ZFIN:ZDB-GENO-221013-7,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0033339	pectoral fin development	rspo3	IGI	ZFIN:ZDB-GENO-221013-6,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Rspo3	IMP	MGI:MGI:5609537	Mouse	PMID:18842812
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Rspo3	IDA		Mouse	PMID:16543246
Biological Process	GO:2000052	positive regulation of non-canonical Wnt signaling pathway	Rspo3	IMP		Mouse	MGI:MGI:5751613|PMID:26766444
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	RSPO3	IDA		Human	PMID:29769720
Biological Process	GO:0048919	posterior lateral line neuromast development	rspo3	IMP	ZFIN:ZDB-MRPHLNO-150114-1	Zfish	PMID:23637337
Biological Process	GO:0042481	regulation of odontogenesis	rspo3	IGI	ZFIN:ZDB-GENO-221013-7,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0042481	regulation of odontogenesis	rspo3	IGI	ZFIN:ZDB-GENO-221013-6,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0042481	regulation of odontogenesis	rspo3	IMP	ZFIN:ZDB-GENO-221013-6	Zfish	PMID:33712657
Biological Process	GO:0002040	sprouting angiogenesis	Rspo3	IMP		Mouse	MGI:MGI:5751613|PMID:26766444

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern