Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RSPO2
  • Mouse genes Rspo2
  • Rat genes Rspo2
  • Zfish genes rspo2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rspo2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008201	heparin binding	Rspo2	IDA		Mouse	PMID:16543246
Molecular Function	GO:0008201	heparin binding	Rspo2	IDA		Mouse	PMID:18256198
Molecular Function	GO:0005515	protein binding	RSPO2	IPI	UniProtKB:P60372	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RSPO2	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RSPO2	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RSPO2	IPI	UniProtKB:Q9H8W4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RSPO2	IPI	UniProtKB:O75473|UniProtKB:Q68DV7|UniProtKB:Q9ULT6	Human	PMID:29769720
Molecular Function	GO:0005102	signaling receptor binding	RSPO2	IPI	UniProtKB:Q9HBX8	Human	PMID:22615920
Cellular Component	GO:0009986	cell surface	Rspo2	IDA		Mouse	PMID:18256198
Cellular Component	GO:0005576	extracellular region	Rspo2	IDA		Mouse	PMID:18256198
Cellular Component	GO:0005576	extracellular region	Rspo2	IDA		Mouse	PMID:16543246
Biological Process	GO:0033335	anal fin development	rspo2	IMP	ZFIN:ZDB-GENO-150311-8	Zfish	PMID:25448983
Biological Process	GO:0030282	bone mineralization	Rspo2	IGI	MGI:MGI:101948	Mouse	PMID:19213727
Biological Process	GO:0030282	bone mineralization	Rspo2	IGI	MGI:MGI:88177	Mouse	PMID:19213727
Biological Process	GO:0060070	canonical Wnt signaling pathway	Rspo2	IMP	MGI:MGI:3045965	Mouse	PMID:18256198
Biological Process	GO:0060070	canonical Wnt signaling pathway	Rspo2	IDA		Mouse	PMID:19213727
Biological Process	GO:0033336	caudal fin development	rspo2	IMP	ZFIN:ZDB-GENO-150311-8	Zfish	PMID:25448983
Biological Process	GO:1904888	cranial skeletal system development	rspo2	IGI	ZFIN:ZDB-GENO-221013-7,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:1904888	cranial skeletal system development	rspo2	IGI	ZFIN:ZDB-GENO-221013-6,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0071542	dopaminergic neuron differentiation	Rspo2	IMP	MGI:MGI:3762378	Mouse	PMID:24066094
Biological Process	GO:0033337	dorsal fin development	rspo2	IMP	ZFIN:ZDB-GENO-150311-8	Zfish	PMID:25448983
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Rspo2	IMP	MGI:MGI:3045965	Mouse	PMID:18256198
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Rspo2	IGI	MGI:MGI:1298218	Mouse	PMID:18256198
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Rspo2	IMP	MGI:MGI:3045965	Mouse	PMID:18256198
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Rspo2	IGI	MGI:MGI:1298218	Mouse	PMID:18256198
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Rspo2	IMP	MGI:MGI:3045965	Mouse	PMID:18256198
Biological Process	GO:0060173	limb development	RSPO2	IMP		Human	PMID:29769720
Biological Process	GO:0060437	lung growth	Rspo2	IMP	MGI:MGI:3045965	Mouse	PMID:18256198
Biological Process	GO:0033338	medial fin development	rspo2	IMP	ZFIN:ZDB-GENO-150311-8	Zfish	PMID:25448983
Biological Process	GO:0042489	negative regulation of odontogenesis of dentin-containing tooth	Rspo2	IMP	MGI:MGI:3839444	Mouse	PMID:24616052
Biological Process	GO:0001649	osteoblast differentiation	Rspo2	IGI	MGI:MGI:88177	Mouse	PMID:19213727
Biological Process	GO:0033339	pectoral fin development	rspo2	IGI	ZFIN:ZDB-GENO-221013-6,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0033339	pectoral fin development	rspo2	IGI	ZFIN:ZDB-GENO-221013-7,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0033339	pectoral fin development	rspo2	IMP	ZFIN:ZDB-GENO-150311-8	Zfish	PMID:25448983
Biological Process	GO:0033340	pelvic fin development	rspo2	IMP	ZFIN:ZDB-GENO-150311-8	Zfish	PMID:25448983
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Rspo2	IDA		Mouse	PMID:19213727
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Rspo2	IDA		Mouse	PMID:18256198
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Rspo2	IGI	MGI:MGI:1298218	Mouse	PMID:18256198
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Rspo2	IMP	MGI:MGI:3045965	Mouse	PMID:18256198
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	RSPO2	IDA		Human	PMID:29769720
Biological Process	GO:0042481	regulation of odontogenesis	rspo2	IGI	ZFIN:ZDB-GENO-221013-7,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0042481	regulation of odontogenesis	rspo2	IGI	ZFIN:ZDB-GENO-221013-6,ZFIN:ZDB-CRISPR-211118-1,ZFIN:ZDB-CRISPR-211118-2,ZFIN:ZDB-CRISPR-211118-3,ZFIN:ZDB-CRISPR-211118-4	Zfish	PMID:33712657
Biological Process	GO:0001501	skeletal system development	rspo2	IMP	ZFIN:ZDB-GENO-150311-8	Zfish	PMID:25448983
Biological Process	GO:0001501	skeletal system development	rspo2	IMP	ZFIN:ZDB-GENO-150311-9	Zfish	PMID:25448983
Biological Process	GO:0060535	trachea cartilage morphogenesis	Rspo2	IGI	MGI:MGI:1298218	Mouse	PMID:18256198

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern