Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RRM2
  • Mouse genes Rrm2
  • Rat genes LOC100359539,Rrm2
  • Zfish genes rrm2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rrm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008199	ferric iron binding	Rrm2	IDA		Mouse	MGI:MGI:5882921|PMID:8876648
Molecular Function	GO:0042802	identical protein binding	Rrm2	IMP		Mouse	MGI:MGI:5888982|PMID:8130196
Molecular Function	GO:0005515	protein binding	RRM2	IPI	UniProtKB:P23921	Human	PMID:17726094
Molecular Function	GO:0005515	protein binding	RRM2	IPI	UniProtKB:P23921	Human	PMID:21336276
Molecular Function	GO:0005515	protein binding	RRM2	IPI	UniProtKB:P23921	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	RRM2	IPI	UniProtKB:P41002	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	RRM2	IPI	UniProtKB:Q9UM11	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	RRM2	IPI	UniProtKB:P23921	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RRM2	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rrm2	IPI	UniProtKB:P07742	Mouse	MGI:MGI:5888982|PMID:8130196
Molecular Function	GO:0005515	protein binding	Rrm2	IPI	PR:P07742	Mouse	PMID:16829694
Molecular Function	GO:0005515	protein binding	Rrm2	IPI	PR:P07742	Mouse	PMID:16861739
Molecular Function	GO:0005515	protein binding	Rrm2	IPI	PR:P09803	Mouse	PMID:12655059
Molecular Function	GO:0042803	protein homodimerization activity	Rrm2	IDA		Mouse	MGI:MGI:5882921|PMID:8876648
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm2	IDA		Mouse	MGI:MGI:3846285|PMID:19176520
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm2	IDA		Mouse	PMID:16829694
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm2	IDA		Mouse	PMID:16861739
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm2	IMP		Mouse	PMID:2684652
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm2	IDA		Mouse	PMID:8612737
Cellular Component	GO:0005829	cytosol	RRM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RRM2	IDA		Human	PMID:18997010
Cellular Component	GO:0005635	nuclear envelope	Rrm2	IDA		Rat	PMID:2205248|RGD:5133697
Cellular Component	GO:0005971	ribonucleoside-diphosphate reductase complex	RRM2	IPI		Human	PMID:22632967
Cellular Component	GO:0005971	ribonucleoside-diphosphate reductase complex	Rrm2	IDA		Mouse	MGI:MGI:5882921|PMID:8876648
Cellular Component	GO:0005971	ribonucleoside-diphosphate reductase complex	Rrm2	IMP		Mouse	MGI:MGI:5888982|PMID:8130196
Cellular Component	GO:0005971	ribonucleoside-diphosphate reductase complex	Rrm2	IDA		Mouse	PMID:19176520
Biological Process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	RRM2	IDA		Human	PMID:16376858
Biological Process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	Rrm2	IDA		Mouse	MGI:MGI:6810812|PMID:12578384
Biological Process	GO:0001824	blastocyst development	Rrm2	IMP		Mouse	PMID:26902285
Biological Process	GO:0009263	deoxyribonucleotide biosynthetic process	Rrm2	IDA		Mouse	MGI:MGI:3846285|PMID:19176520
Biological Process	GO:0009262	deoxyribonucleotide metabolic process	Rrm2	IDA		Mouse	PMID:12655059
Biological Process	GO:0000278	mitotic cell cycle	Rrm2	IEP		Rat	PMID:6388757|RGD:5133709
Biological Process	GO:0008284	positive regulation of cell population proliferation	Rrm2	IMP		Rat	PMID:17404105|RGD:2316866
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	RRM2	IDA		Human	PMID:24253041
Biological Process	GO:0051290	protein heterotetramerization	Rrm2	IPI	UniProtKB:P07742	Mouse	MGI:MGI:3846285|PMID:19176520
Biological Process	GO:0006206	pyrimidine nucleobase metabolic process	Rrm2	IEP		Rat	PMID:10204803|RGD:5133695
Biological Process	GO:0009185	ribonucleoside diphosphate metabolic process	RRM2	IDA		Human	PMID:16376858
Biological Process	GO:0009185	ribonucleoside diphosphate metabolic process	Rrm2	IDA		Mouse	MGI:MGI:6810812|PMID:12578384

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern