Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPS6KA5
  • Mouse genes Rps6ka5
  • Rat genes Rps6ka5
  • Zfish genes rps6ka5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6ka5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	RPS6KA5	IDA		Human	PMID:9687510
Molecular Function	GO:0005524	ATP binding	Rps6ka5	IDA		Mouse	MGI:MGI:3687920|PMID:12628924
Molecular Function	GO:0044024	histone H2AS1 kinase activity	RPS6KA5	IDA		Human	PMID:15010469
Molecular Function	GO:0035175	histone H3S10 kinase activity	RPS6KA5	IMP		Human	PMID:12773393
Molecular Function	GO:0044022	histone H3S28 kinase activity	RPS6KA5	IMP		Human	PMID:12773393
Molecular Function	GO:0005515	protein binding	RPS6KA5	IPI	UniProtKB:Q9NYL2	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	RPS6KA5	IPI	UniProtKB:Q9Y4C1	Human	PMID:25535969
Molecular Function	GO:0005515	protein binding	RPS6KA5	IPI	UniProtKB:Q9UI47-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rps6ka5	IPI	UniProtKB:P11416	Mouse	MGI:MGI:3830444|PMID:19078967
Molecular Function	GO:0004674	protein serine/threonine kinase activity	RPS6KA5	IDA		Human	PMID:9687510
Molecular Function	GO:0004674	protein serine/threonine kinase activity	RPS6KA5	IDA		Human	PMID:9873047
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Rps6ka5	IDA		Mouse	MGI:MGI:3687920|PMID:12628924
Molecular Function	GO:0004713	protein tyrosine kinase activity	RPS6KA5	IDA		Human	PMID:9873047
Cellular Component	GO:0005737	cytoplasm	RPS6KA5	IDA		Human	PMID:18511904
Cellular Component	GO:0005654	nucleoplasm	RPS6KA5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RPS6KA5	IMP		Human	PMID:12628924
Cellular Component	GO:0005634	nucleus	RPS6KA5	IDA		Human	PMID:18511904
Cellular Component	GO:0005634	nucleus	RPS6KA5	IDA		Human	PMID:9687510
Cellular Component	GO:0005634	nucleus	Rps6ka5	IDA		Mouse	MGI:MGI:3687920|PMID:12628924
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	RPS6KA5	IMP		Human	PMID:20018936
Biological Process	GO:0035556	intracellular signal transduction	RPS6KA5	IDA		Human	PMID:9687510
Biological Process	GO:0035556	intracellular signal transduction	Rps6ka5	IDA		Mouse	MGI:MGI:3687920|PMID:12628924
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	RPS6KA5	IDA		Human	PMID:15010469
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RPS6KA5	IMP		Human	PMID:12628924
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RPS6KA5	IMP		Human	PMID:18511904
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RPS6KA5	IMP		Human	PMID:20018936
Biological Process	GO:0043687	post-translational protein modification	RPS6KA5	IMP		Human	PMID:12773393
Biological Process	GO:0043687	post-translational protein modification	RPS6KA5	IDA		Human	PMID:15010469
Biological Process	GO:0006468	protein phosphorylation	RPS6KA5	IDA		Human	PMID:9687510
Biological Process	GO:0006468	protein phosphorylation	Rps6ka5	IDA		Mouse	MGI:MGI:3687920|PMID:12628924
Biological Process	GO:0006355	regulation of DNA-templated transcription	RPS6KA5	IMP		Human	PMID:12763138
Biological Process	GO:0006355	regulation of DNA-templated transcription	RPS6KA5	IDA		Human	PMID:9687510
Biological Process	GO:0006355	regulation of DNA-templated transcription	Rps6ka5	IDA		Mouse	MGI:MGI:3687920|PMID:12628924
Biological Process	GO:0099175	regulation of postsynapse organization	Rps6ka5	IDA		Mouse	PMID:23077336
Biological Process	GO:0099175	regulation of postsynapse organization	Rps6ka5	IMP		Mouse	PMID:23077336

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern