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Rps6ka5 Gene Detail
Summary
  • Symbol
    Rps6ka5
  • Name
    ribosomal protein S6 kinase, polypeptide 5
  • Synonyms
    3110005L17Rik, 6330404E13Rik, MSK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920336
    NCBI Gene: 73086
  • Gene Overview
    MyGene.info: RPS6KA5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:100549778-100725395 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 50.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920336
protein coding gene Chr12:100548439-100726983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020019
protein coding gene Chr12:102021618-102211166 (-)
A/J MGP_AJ_G0019974
protein coding gene Chr12:98185030-98370477 (-)
AKR/J MGP_AKRJ_G0019950
protein coding gene Chr12:100853653-101044483 (-)
BALB/cJ MGP_BALBcJ_G0019960
protein coding gene Chr12:98536504-98713959 (-)
C3H/HeJ MGP_C3HHeJ_G0019762
protein coding gene Chr12:101387804-101569568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020409
protein coding gene Chr12:105180997-105379153 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018023
protein coding gene Chr12:95163791-95342401 (-)
CAST/EiJ MGP_CASTEiJ_G0019308
protein coding gene Chr12:96510451-96689631 (-)
CBA/J MGP_CBAJ_G0019734
protein coding gene Chr12:109069719-109253216 (-)
DBA/2J MGP_DBA2J_G0019845
protein coding gene Chr12:97633579-97811369 (-)
FVB/NJ MGP_FVBNJ_G0019834
protein coding gene Chr12:96350610-96532278 (-)
LP/J MGP_LPJ_G0019921
protein coding gene Chr12:101861358-102047857 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019876
protein coding gene Chr12:112649602-112853111 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020438
protein coding gene Chr12:100421122-100608034 (-)
PWK/PhJ MGP_PWKPhJ_G0019072
protein coding gene Chr12:92266900-92445947 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018868
protein coding gene Chr12:94616168-94805427 (-)
WSB/EiJ MGP_WSBEiJ_G0019362
protein coding gene Chr12:101281531-101466785 (-)



Homology
more
  • Human Ortholog
    RPS6KA5, ribosomal protein S6 kinase A5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RPS6KA5, ribosomal protein S6 kinase A5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSK1, MSPK1, RLPK
  • Links
    NCBI Gene ID: 9252
    neXtProt AC: NX_O75582
    UniProt: O75582

  • Chr Location
    14q32.11; chr14:90868122-91060649 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a mutant allele exhibit altered response to cocaine including decreased hyperlocomotor activity and sensitization at a lower dose. Mice homozygous for a kinase dead allele exhibit altered experience-dependent synaptic plasticity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73086 NCBI Gene Model | MGI Sequence Detail 175618 C57BL/6J ±  kb
transcript NM_153587 RefSeq | MGI Sequence Detail 5852 C57BL/6  
polypeptide Q8C050 UniProt | EBI | MGI Sequence Detail 863 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1917998, MGI:2144911
References
more
  • Summaries
    All 80
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 42
  • Earliest
    J:49137 Deak M, et al., Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41
  • Latest
    J:255785 Daumas S, et al., The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory. eNeuro. 2017 Jan-Feb;4(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory