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Rps6ka5 Gene Detail
Summary
  • Symbol
    Rps6ka5
  • Name
    ribosomal protein S6 kinase, polypeptide 5
  • Synonyms
    3110005L17Rik, 6330404E13Rik, MSK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920336
    NCBI Gene: 73086
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:100514692-100691693 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 50.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1007 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920336
 protein coding gene Chr12:100514692-100693242 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020019
 protein coding gene Chr12:102021618-102211166 (-)
A/J MGP_AJ_G0019974
 protein coding gene Chr12:98185030-98370477 (-)
AKR/J MGP_AKRJ_G0019950
 protein coding gene Chr12:100853653-101044483 (-)
BALB/cJ MGP_BALBcJ_G0019960
 protein coding gene Chr12:98536504-98713959 (-)
C3H/HeJ MGP_C3HHeJ_G0019762
 protein coding gene Chr12:101387804-101569568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020409
 protein coding gene Chr12:105180997-105379153 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018023
 protein coding gene Chr12:95163791-95342401 (-)
CAST/EiJ MGP_CASTEiJ_G0019308
 protein coding gene Chr12:96510451-96689631 (-)
CBA/J MGP_CBAJ_G0019734
 protein coding gene Chr12:109069719-109253216 (-)
DBA/2J MGP_DBA2J_G0019845
 protein coding gene Chr12:97633579-97811369 (-)
FVB/NJ MGP_FVBNJ_G0019834
 protein coding gene Chr12:96350610-96532278 (-)
LP/J MGP_LPJ_G0019921
 protein coding gene Chr12:101861358-102047857 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019876
 protein coding gene Chr12:112649602-112853111 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020438
 protein coding gene Chr12:100421122-100608034 (-)
PWK/PhJ MGP_PWKPhJ_G0019072
 protein coding gene Chr12:92266900-92445947 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018868
 protein coding gene Chr12:94616168-94805427 (-)
WSB/EiJ MGP_WSBEiJ_G0019362
 protein coding gene Chr12:101281531-101466785 (-)



Homology
more
  • Human Ortholog
    RPS6KA5, ribosomal protein S6 kinase A5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS6KA5, ribosomal protein S6 kinase A5
  • Synonyms
    MSK1, MSPK1, RLPK
  • Links
    NCBI Gene ID: 9252
    neXtProt AC: NX_O75582
    UniProt: O75582

  • Chr Location
    14q32.11; chr14:90847861-91060641 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutant allele exhibit altered response to cocaine including decreased hyperlocomotor activity and sensitization at a lower dose. Mice homozygous for a kinase dead allele exhibit altered experience-dependent synaptic plasticity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73086 NCBI Gene Model | MGI Sequence Detail 177002 C57BL/6J ±  kb
    transcript NM_153587 RefSeq | MGI Sequence Detail 5852 C57BL/6  
    polypeptide Q8C050 UniProt | EBI | MGI Sequence Detail 863 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917998, MGI:2144911
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 50
    • Earliest
      J:49137 Deak M, et al., Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41
    • Latest
      J:342912 More L, et al., MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan. Aging (Albany NY). 2023 Jul 10;15(13):6031-6072
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory