Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RNF43
  • Mouse genes Rnf43
  • Rat genes Rnf43
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rnf43

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	RNF43	IPI	UniProtKB:Q13467	Human	PMID:22895187
Molecular Function	GO:0005515	protein binding	RNF43	IPI	UniProtKB:P0CG47	Human	PMID:18313049
Molecular Function	GO:0005515	protein binding	RNF43	IPI	UniProtKB:P61077	Human	PMID:18313049
Molecular Function	GO:0005515	protein binding	RNF43	IPI	UniProtKB:P62837	Human	PMID:18313049
Molecular Function	GO:0005515	protein binding	RNF43	IPI	UniProtKB:Q9ULX6	Human	PMID:18313049
Molecular Function	GO:0005515	protein binding	RNF43	IPI	UniProtKB:P61077	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	RNF43	IPI	UniProtKB:P62837	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	RNF43	IPI	UniProtKB:Q6UXX9	Human	PMID:29769720
Molecular Function	GO:0005515	protein binding	Rnf43	IPI	UniProtKB:Q9D1E5	Mouse	MGI:MGI:6303730|PMID:31073040
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF43	IDA		Human	PMID:22575959
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF43	IDA		Human	PMID:22895187
Cellular Component	GO:0005886	plasma membrane	RNF43	IDA		Human	PMID:22575959
Cellular Component	GO:0005886	plasma membrane	RNF43	IDA		Human	PMID:22895187
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	RNF43	IMP		Human	PMID:22575959
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	RNF43	IMP		Human	PMID:22895187
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Rnf43	IMP		Mouse	MGI:MGI:5433224|PMID:22895187
Biological Process	GO:0016567	protein ubiquitination	RNF43	IDA		Human	PMID:22575959
Biological Process	GO:0072089	stem cell proliferation	Rnf43	IMP		Mouse	MGI:MGI:5433224|PMID:22895187
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RNF43	IDA		Human	PMID:22895187
Biological Process	GO:0038018	Wnt receptor catabolic process	RNF43	IDA		Human	PMID:22895187

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern