Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ripk3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RIPK3
- Mouse genes Ripk3
- Rat genes Ripk3
- Zfish genes ripk3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ripk3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	RIPK3	IPI	UniProtKB:Q9Y572	Human	PMID:22817896
Molecular Function	GO:0004704	NF-kappaB-inducing kinase activity	Ripk3	IDA		Mouse	PMID:10490590
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13546	Human	PMID:19524512
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13546	Human	PMID:19524513
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q9H171	Human	PMID:19590578
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q92974	Human	PMID:21887730
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13489	Human	PMID:21931591
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13490	Human	PMID:21931591
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13546	Human	PMID:22265413
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q8NB16	Human	PMID:22265413
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13546	Human	PMID:22265414
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q8NB16	Human	PMID:22265414
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13546	Human	PMID:22817896
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:P89462	Human	PMID:26559832
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13546	Human	PMID:26559832
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:U5TQE9	Human	PMID:26559832
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:O60566	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q12933	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q13546	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q8NB16	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q96FA3	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:Q9UNE7	Human	PMID:29883609
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:J9TC74	Human	PMID:30185776
Molecular Function	GO:0005515	protein binding	RIPK3	IPI	UniProtKB:P08543	Human	PMID:33348174
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:5706670\|PMID:26649818
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9UER7	Mouse	MGI:MGI:5468077\|PMID:23260419
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:5926457\|PMID:28842570
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q8C669	Mouse	MGI:MGI:6163945\|PMID:29883609
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:5315337\|PMID:21052097
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9QY24	Mouse	MGI:MGI:5927398\|PMID:28607035
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:5437800\|PMID:22922364
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9D2Y4	Mouse	MGI:MGI:5796070\|PMID:26559832
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:4947443\|PMID:21368763
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9D2Y4	Mouse	MGI:MGI:6436434\|PMID:27321907
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q60855\|UniProtKB:Q61160	Mouse	MGI:MGI:4359574\|PMID:19524513
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9D2Y4	Mouse	MGI:MGI:5532864\|PMID:24095729
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:5566546\|PMID:24557836
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:6362574\|PMID:31519887
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9D2Y4	Mouse	MGI:MGI:5516182\|PMID:22265413
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9QY24	Mouse	MGI:MGI:6436371\|PMID:22423968
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	UniProtKB:Q9D2Y4	Mouse	MGI:MGI:5532892\|PMID:24012422
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	MGI:MGI:1927664	Mouse	PMID:23201684
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	PR:Q9ET01	Mouse	PMID:19498109
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	PR:P15105	Mouse	PMID:19498109
Molecular Function	GO:0005515	protein binding	Ripk3	IPI	PR:P26443	Mouse	PMID:19498109
Molecular Function	GO:0004672	protein kinase activity	RIPK3	IDA		Human	PMID:22265413
Molecular Function	GO:0004672	protein kinase activity	RIPK3	IMP		Human	PMID:22265414
Molecular Function	GO:0004672	protein kinase activity	RIPK3	IMP		Human	PMID:22817896
Molecular Function	GO:0004672	protein kinase activity	RIPK3	IMP		Human	PMID:29883609
Molecular Function	GO:0004672	protein kinase activity	Ripk3	IDA		Mouse	PMID:10490590
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ripk3	IDA		Mouse	MGI:MGI:6434626\|PMID:32296175
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ripk3	IDA		Mouse	MGI:MGI:5532892\|PMID:24012422
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ripk3	IDA		Mouse	MGI:MGI:6436412\|PMID:32200799
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ripk3	IDA		Mouse	MGI:MGI:5532864\|PMID:24095729
Molecular Function	GO:0044877	protein-containing complex binding	RIPK3	IMP		Human	PMID:22265414
Cellular Component	GO:0005737	cytoplasm	Ripk3	IDA		Mouse	MGI:MGI:5927398\|PMID:28607035
Cellular Component	GO:0005737	cytoplasm	Ripk3	IDA		Mouse	MGI:MGI:6436412\|PMID:32200799
Cellular Component	GO:0005737	cytoplasm	Ripk3	IDA		Mouse	MGI:MGI:6434626\|PMID:32296175
Cellular Component	GO:0005829	cytosol	RIPK3	IDA		Human	PMID:22265413
Cellular Component	GO:0005622	intracellular anatomical structure	Ripk3	IDA		Mouse	PMID:10490590
Cellular Component	GO:0005634	nucleus	Ripk3	IDA		Mouse	MGI:MGI:6434626\|PMID:32296175
Cellular Component	GO:0005634	nucleus	Ripk3	IDA		Mouse	MGI:MGI:6436412\|PMID:32200799
Cellular Component	GO:0005634	nucleus	Ripk3	IDA		Mouse	MGI:MGI:5927398\|PMID:28607035
Cellular Component	GO:0032991	protein-containing complex	RIPK3	IDA		Human	PMID:22817896
Biological Process	GO:0032147	activation of protein kinase activity	RIPK3	IMP		Human	PMID:22817896
Biological Process	GO:1990000	amyloid fibril formation	RIPK3	IMP		Human	PMID:22817896
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Ripk3	IMP		Mouse	MGI:MGI:6140989\|PMID:27258785
Biological Process	GO:0051607	defense response to virus	Ripk3	IDA		Mouse	MGI:MGI:6436371\|PMID:22423968
Biological Process	GO:0051607	defense response to virus	Ripk3	IMP		Mouse	MGI:MGI:6436445\|PMID:27746097
Biological Process	GO:0051607	defense response to virus	Ripk3	IDA		Mouse	MGI:MGI:6434626\|PMID:32296175
Biological Process	GO:0051607	defense response to virus	Ripk3	IDA		Mouse	MGI:MGI:6357088\|PMID:30635240
Biological Process	GO:0051607	defense response to virus	Ripk3	IMP		Mouse	MGI:MGI:6442612\|PMID:27917412
Biological Process	GO:0051607	defense response to virus	Ripk3	IMP		Mouse	MGI:MGI:6436434\|PMID:27321907
Biological Process	GO:0051607	defense response to virus	Ripk3	IDA		Mouse	MGI:MGI:6436412\|PMID:32200799
Biological Process	GO:0097528	execution phase of necroptosis	Ripk3	IMP		Mouse	MGI:MGI:6436445\|PMID:27746097
Biological Process	GO:0097528	execution phase of necroptosis	Ripk3	IMP		Mouse	MGI:MGI:6442612\|PMID:27917412
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ripk3	IDA		Mouse	PMID:10490590
Biological Process	GO:0048535	lymph node development	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0070266	necroptotic process	RIPK3	IMP		Human	PMID:21737330
Biological Process	GO:0070266	necroptotic process	RIPK3	IMP		Human	PMID:29883609
Biological Process	GO:0070266	necroptotic process	Ripk3	IMP		Mouse	MGI:MGI:5532892\|PMID:24012422
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:109324	Mouse	PMID:22675671
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:104798	Mouse	PMID:21368763
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:1261423	Mouse	PMID:21368763
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:1336166	Mouse	PMID:21368763
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:104798	Mouse	PMID:19498109
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:1261423	Mouse	PMID:21402742
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:108212	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:1921506	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Ripk3	IGI	MGI:MGI:1336166	Mouse	PMID:22675671
Biological Process	GO:0097527	necroptotic signaling pathway	RIPK3	IMP		Human	PMID:22265413
Biological Process	GO:0097527	necroptotic signaling pathway	RIPK3	IMP		Human	PMID:22817896
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Ripk3	IDA		Mouse	PMID:10490590
Biological Process	GO:0051351	positive regulation of ligase activity	Ripk3	IDA		Mouse	PMID:19498109
Biological Process	GO:0060545	positive regulation of necroptotic process	RIPK3	IDA		Human	PMID:22265414
Biological Process	GO:0060545	positive regulation of necroptotic process	RIPK3	IMP		Human	PMID:22817896
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IMP		Mouse	MGI:MGI:5602911\|PMID:24813849
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IDA		Mouse	MGI:MGI:6436371\|PMID:22423968
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IMP		Mouse	MGI:MGI:5315337\|PMID:21052097
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IMP		Mouse	MGI:MGI:6436434\|PMID:27321907
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IDA		Mouse	MGI:MGI:6436412\|PMID:32200799
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IDA		Mouse	MGI:MGI:6434626\|PMID:32296175
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IMP		Mouse	MGI:MGI:5516181\|PMID:22265414
Biological Process	GO:0060545	positive regulation of necroptotic process	Ripk3	IMP		Mouse	MGI:MGI:5602910\|PMID:24813850
Biological Process	GO:0010940	positive regulation of necrotic cell death	Ripk3	IMP		Mouse	MGI:MGI:5796070\|PMID:26559832
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RIPK3	IDA		Human	PMID:21931591
Biological Process	GO:0051353	positive regulation of oxidoreductase activity	Ripk3	IDA		Mouse	PMID:19498109
Biological Process	GO:0010922	positive regulation of phosphatase activity	RIPK3	IMP		Human	PMID:22265414
Biological Process	GO:0090312	positive regulation of protein deacetylation	Ripk3	IGI	MGI:MGI:1927664	Mouse	PMID:23201684
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Ripk3	IMP		Mouse	MGI:MGI:5315337\|PMID:21052097
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Ripk3	IMP		Mouse	PMID:19498109
Biological Process	GO:0051347	positive regulation of transferase activity	Ripk3	IGI	MGI:MGI:108212	Mouse	PMID:19498109
Biological Process	GO:0097300	programmed necrotic cell death	Ripk3	IMP		Mouse	MGI:MGI:6140989\|PMID:27258785
Biological Process	GO:0046777	protein autophosphorylation	RIPK3	IDA		Human	PMID:22265414
Biological Process	GO:0006476	protein deacetylation	Ripk3	IGI	MGI:MGI:1927664	Mouse	PMID:23201684
Biological Process	GO:0072593	reactive oxygen species metabolic process	Ripk3	IMP		Mouse	PMID:19498109
Biological Process	GO:0046006	regulation of activated T cell proliferation	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0070235	regulation of activation-induced cell death of T cells	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0002819	regulation of adaptive immune response	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0042981	regulation of apoptotic process	Ripk3	IMP		Mouse	MGI:MGI:6436445\|PMID:27746097
Biological Process	GO:0042981	regulation of apoptotic process	Ripk3	IMP		Mouse	MGI:MGI:6436434\|PMID:27321907
Biological Process	GO:0042981	regulation of apoptotic process	Ripk3	IMP		Mouse	MGI:MGI:6442612\|PMID:27917412
Biological Process	GO:0042981	regulation of apoptotic process	Ripk3	IDA		Mouse	MGI:MGI:6436412\|PMID:32200799
Biological Process	GO:2000452	regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	Ripk3	IMP		Mouse	PMID:21052097
Biological Process	GO:0001914	regulation of T cell mediated cytotoxicity	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0032649	regulation of type II interferon production	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0048536	spleen development	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0033077	T cell differentiation in thymus	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0043029	T cell homeostasis	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153
Biological Process	GO:0048538	thymus development	Ripk3	IGI	UniProtKB:Q61160	Mouse	MGI:MGI:5291865\|PMID:21876153

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.