Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RFC1
  • Mouse genes Rfc1
  • Rat genes Rfc1
  • Zfish genes rfc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rfc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061860	DNA clamp unloader activity	RFC1	IMP		Human	PMID:23277426
Molecular Function	GO:0003690	double-stranded DNA binding	Rfc1	IDA		Rat	PMID:9826522|RGD:2307113
Molecular Function	GO:0005515	protein binding	RFC1	IPI	UniProtKB:P35250	Human	PMID:15655353
Molecular Function	GO:0005515	protein binding	RFC1	IPI	UniProtKB:Q14683	Human	PMID:16438930
Molecular Function	GO:0005515	protein binding	RFC1	IPI	UniProtKB:P35250	Human	PMID:9488738
Molecular Function	GO:0005515	protein binding	Rfc1	IPI	RGD:3269	Rat	PMID:7729533|RGD:2307140
Molecular Function	GO:0019904	protein domain specific binding	Rfc1	IPI	RGD:2326	Rat	PMID:11356826|RGD:2307111
Molecular Function	GO:0043565	sequence-specific DNA binding	Rfc1	IDA		Rat	PMID:9826522|RGD:2307113
Cellular Component	GO:0005737	cytoplasm	Rfc1	IDA		Rat	PMID:7729533|RGD:2307140
Cellular Component	GO:0005663	DNA replication factor C complex	RFC1	IDA		Human	PMID:9488738
Cellular Component	GO:0031391	Elg1 RFC-like complex	RFC1	IDA		Human	PMID:23277426
Cellular Component	GO:0070062	extracellular exosome	RFC1	HDA		Human	PMID:19056867
Cellular Component	GO:0005730	nucleolus	Rfc1	IDA		Rat	PMID:7729533|RGD:2307140
Cellular Component	GO:0005654	nucleoplasm	RFC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Rfc1	IDA		Mouse	PMID:11555636
Cellular Component	GO:0005634	nucleus	Rfc1	IDA		Rat	PMID:11356826|RGD:2307111
Cellular Component	GO:0005634	nucleus	Rfc1	IDA		Rat	PMID:9826522|RGD:2307113
Cellular Component	GO:0032991	protein-containing complex	Rfc1	IDA		Rat	PMID:11356826|RGD:2307111
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Rfc1	IMP		Rat	PMID:9826522|RGD:2307113
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Rfc1	IDA		Rat	PMID:9677428|RGD:633853
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Rfc1	IMP		Rat	PMID:9826522|RGD:2307113

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern