Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAP2A
  • Mouse genes Rap2a
  • Rat genes Rap2a
  • Zfish genes rap2ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rap2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	RAP2A	IMP		Human	PMID:9312017
Molecular Function	GO:0005525	GTP binding	RAP2A	IMP		Human	PMID:10591105
Molecular Function	GO:0005525	GTP binding	RAP2A	IDA		Human	PMID:22797597
Molecular Function	GO:0005525	GTP binding	RAP2A	IMP		Human	PMID:9312017
Molecular Function	GO:0003924	GTPase activity	RAP2A	IDA		Human	PMID:1900290
Molecular Function	GO:0000287	magnesium ion binding	RAP2A	IMP		Human	PMID:10591105
Molecular Function	GO:0000287	magnesium ion binding	RAP2A	IMP		Human	PMID:9312017
Molecular Function	GO:0005515	protein binding	RAP2A	IPI	UniProtKB:O95819	Human	PMID:14966141
Molecular Function	GO:0005515	protein binding	RAP2A	IPI	UniProtKB:Q9UKE5	Human	PMID:15342639
Molecular Function	GO:0005515	protein binding	RAP2A	IPI	UniProtKB:P46934	Human	PMID:20159449
Molecular Function	GO:0005515	protein binding	RAP2A	IPI	UniProtKB:Q9UKE5	Human	PMID:20159449
Molecular Function	GO:0005515	protein binding	RAP2A	IPI	UniProtKB:P54852	Human	PMID:30614533
Molecular Function	GO:0005515	protein binding	RAP2A	IPI	UniProtKB:Q59EK9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAP2A	IPI	UniProtKB:Q9NZL6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rap2a	IPI	UniProtKB:P97492	Mouse	MGI:MGI:5009199|PMID:10926822
Molecular Function	GO:0005515	protein binding	Rap2a	IPI	UniProtKB:P46935|UniProtKB:P83510	Mouse	MGI:MGI:4835109|PMID:20159449
Cellular Component	GO:0005829	cytosol	Rap2a	IDA		Mouse	PMID:19061864
Cellular Component	GO:0016020	membrane	Rap2a	IDA		Mouse	PMID:19061864
Cellular Component	GO:0005886	plasma membrane	RAP2A	IDA		Human	PMID:22797597
Cellular Component	GO:0055037	recycling endosome	RAP2A	IDA		Human	PMID:19061864
Cellular Component	GO:0055037	recycling endosome	RAP2A	IDA		Human	PMID:22797597
Cellular Component	GO:0055037	recycling endosome	Rap2a	IDA		Mouse	PMID:19061864
Cellular Component	GO:0055038	recycling endosome membrane	RAP2A	IDA		Human	PMID:19061864
Cellular Component	GO:0055038	recycling endosome membrane	Rap2a	IDA		Mouse	MGI:MGI:3822406|PMID:19061864
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	RAP2A	IDA		Human	PMID:15953419
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	RAP2A	IMP		Human	PMID:15953419
Cellular Component	GO:0045202	synapse	Rap2a	IDA		Rat	PMID:20159449|RGD:8554407
Cellular Component	GO:0097060	synaptic membrane	Rap2a	IDA		Rat	PMID:20159449|RGD:8554407
Biological Process	GO:0031532	actin cytoskeleton reorganization	RAP2A	IDA		Human	PMID:15342639
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	RAP2A	IDA		Human	PMID:22797597
Biological Process	GO:0045184	establishment of protein localization	RAP2A	IDA		Human	PMID:19061864
Biological Process	GO:0030033	microvillus assembly	RAP2A	IMP		Human	PMID:22797597
Biological Process	GO:0030336	negative regulation of cell migration	Rap2a	IDA		Mouse	PMID:19061864
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	RAP2A	IDA		Human	PMID:15342639
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	Rap2a	IDA		Mouse	PMID:19061864
Biological Process	GO:0001934	positive regulation of protein phosphorylation	RAP2A	IMP		Human	PMID:22797597
Biological Process	GO:0008104	protein localization	RAP2A	IDA		Human	PMID:15342639
Biological Process	GO:0072659	protein localization to plasma membrane	RAP2A	IMP		Human	PMID:22797597
Biological Process	GO:0032486	Rap protein signal transduction	Rap2a	IDA		Mouse	MGI:MGI:3822406|PMID:19061864
Biological Process	GO:0048814	regulation of dendrite morphogenesis	RAP2A	IDA		Human	PMID:20159449
Biological Process	GO:0046328	regulation of JNK cascade	RAP2A	IDA		Human	PMID:14966141
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	RAP2A	IDA		Human	PMID:15953419
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	RAP2A	IMP		Human	PMID:15953419
Biological Process	GO:0051963	regulation of synapse assembly	RAP2A	IDA		Human	PMID:30063210
Biological Process	GO:0051963	regulation of synapse assembly	RAP2A	IMP		Human	PMID:30063210

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern