Rap2a Gene Detail

Summary

• Symbol
  Rap2a
• Name
  RAS related protein 2a
• Synonyms
  5830461H18Rik

• Feature Type
  protein coding gene
• IDs
  MGI:97855
  NCBI Gene: 76108
• Gene Overview
  MyGene.info: RAP2A

Location & Maps

• Sequence Map
  Chr14:120503601-120507194 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    3594 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 64.72 cM
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  RAP2A, RAP2A, member of RAS oncogene family

• Vertebrate Orthologs
  9

• Human Ortholog
  RAP2A, RAP2A, member of RAS oncogene family
  Orthology source: HomoloGene, HGNC
• Synonyms
  KREV, K-REV, RAP2, RbBP-30
• Links
  HGNC:9861

  NCBI Gene ID: 5911

  neXtProt AC: NX_P10114

  UniProt: P10114

  
  
• Chr Location
  13q32.1; chr13:97434221-97467998 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 10875
  1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: RAP2A
• Protein SuperFamily
  ras protein
• Gene Tree
  Rap2a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Gene trapped
  2
• Radiation induced
  1
• Genomic Mutations
  2 involving Rap2a
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  7 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  30
• GO References
  6

• External Resources
  FuncBase

Expression

• cDNA Data
  92
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase rap2a

Interactions

• Rap2a interacts with 302 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  25
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS27341.1
• UniGene
  261448

• VEGA
  OTTMUSG00000017002 (Evidence)
• Ensembl
  ENSMUSG00000051615 (Evidence)
• NCBI Gene
  76108

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000017002	VEGA Gene Model | MGI Sequence Detail	3594	C57BL/6J
transcript	OTTMUST00000041224	VEGA | MGI Sequence Detail	3594	Not Applicable
polypeptide	OTTMUSP00000018473	VEGA | MGI Sequence Detail	79	Not Applicable

Polymorphisms

• SNPs within 2kb
  312 from dbSNP Build 142

• RFLP
  1

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000013723 ras-related protein Rap-2a
  (term hierarchy)
• InterPro Domains
  IPR027417 P-loop containing nucleoside triphosphate hydrolase
  IPR001806 Small GTPase superfamily
  IPR020849 Small GTPase superfamily, Ras type
  IPR005225 Small GTP-binding protein domain

Molecular
Reagents

• All nucleic 93

  cDNA 93

  
  

  Microarray probesets 5

Other
Accession IDs

MGD-MRK-13764, MGI:1923358

References

• Summaries
  All 33

  Developmental Gene Expression 1

  Gene Ontology 6

  Phenotypes 6
• Earliest
  J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
• Latest
  J:164745 Kawabe H, et al., Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron. 2010 Feb 11;65(3):358-72