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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rab5a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rab5a
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0019003GDP bindingRAB5AIDAHumanPMID:15378032
Molecular FunctionGO:0019003GDP bindingRAB5AIDAHumanPMID:23382462
Molecular FunctionGO:0051021GDP-dissociation inhibitor bindingRab5aIDARatPMID:14709549|RGD:1359793
Molecular FunctionGO:0005525GTP bindingRAB5AIDAHumanPMID:15378032
Molecular FunctionGO:0003924GTPase activityRAB5AIDAHumanPMID:15378032
Molecular FunctionGO:0003924GTPase activityRAB5AIDAHumanPMID:17562788
Molecular FunctionGO:0003924GTPase activityRAB5AIDAHumanPMID:24891604
Molecular FunctionGO:0003924GTPase activityRab5aIDAMousePMID:12446704
Molecular FunctionGO:0019001guanyl nucleotide bindingRab5aIDAMousePMID:12446704
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q15075HumanPMID:10491193
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q15075HumanPMID:11870209
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q8NEU8HumanPMID:15016378
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UKG1HumanPMID:15016378
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:P37840HumanPMID:15207266
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9P2R3HumanPMID:15328530
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:P23727HumanPMID:15377662
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q15276HumanPMID:15378032
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9H1K0HumanPMID:16034420
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q96NW4HumanPMID:16525121
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q01968HumanPMID:16902405
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q15075HumanPMID:16902405
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q96HU1HumanPMID:17562788
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UKG1HumanPMID:17581628
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UKG1HumanPMID:18034774
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q96Q42HumanPMID:21300063
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q01968HumanPMID:21378754
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UH99HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:O75503HumanPMID:22431521
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:P51149HumanPMID:22431521
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9BV81HumanPMID:23182941
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UJ41HumanPMID:23382462
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q15042HumanPMID:24891604
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q01968HumanPMID:25107275
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q13492HumanPMID:26005850
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UH99HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UH99HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UKG1HumanPMID:29568061
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UH99HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UKG1HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:O15273HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:O15287HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:O60506-4HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:P14136HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:P15923-3HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:P17024HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q0VD86HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q6IAA8HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q6ZQX7-4HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q8TAB5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q96HB5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q96PV4HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9H7C4HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9NS73-5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9UQM7HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q9Y3D0HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:P24386HumanPMID:7957092
Molecular FunctionGO:0005515protein bindingRAB5AIPIUniProtKB:Q15075HumanPMID:9697774
Molecular FunctionGO:0005515protein bindingRab5aIPIUniProtKB:Q8K3G9MouseMGI:MGI:6271154|PMID:25568335
Molecular FunctionGO:0005515protein bindingRab5aIPIUniProtKB:Q01968,UniProtKB:Q8CDA1MouseMGI:MGI:5763358|PMID:25869668
Molecular FunctionGO:0005515protein bindingRab5aIPIPR:Q80Y56MousePMID:20534488
Molecular FunctionGO:0005515protein bindingRab5aIPIPR:Q8BL66MousePMID:20534488
Cellular ComponentGO:0015629actin cytoskeletonRab5aIDAMousePMID:21419809
Cellular ComponentGO:0030424axonRab5al1IDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0030424axonRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0043679axon terminusRab5al1IDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0043679axon terminusRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0005737cytoplasmRAB5AIDAHumanPMID:18034774
Cellular ComponentGO:0005737cytoplasmRAB5AIDAHumanPMID:21266579
Cellular ComponentGO:0005737cytoplasmRab5aIDAMousePMID:18656450
Cellular ComponentGO:0005737cytoplasmRab5aIDARatPMID:16154939|RGD:2306449
Cellular ComponentGO:0098559cytoplasmic side of early endosome membraneRAB5AIMPHumanPMID:23382462
Cellular ComponentGO:0005829cytosolRAB5AIDAHumanPMID:23382462
Cellular ComponentGO:0030425dendriteRab5al1IDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0030425dendriteRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0005769early endosomeRAB5AIDAHumanPMID:15078902
Cellular ComponentGO:0005769early endosomeRAB5AIDAHumanPMID:15378032
Cellular ComponentGO:0005769early endosomeRAB5AIDAHumanPMID:17562788
Cellular ComponentGO:0005769early endosomeRAB5AIDAHumanPMID:18767904
Cellular ComponentGO:0005769early endosomeRAB5AIDAHumanPMID:21645192
Cellular ComponentGO:0005769early endosomeRAB5AIDAHumanPMID:24334765
Cellular ComponentGO:0005769early endosomeRAB5AIDAHumanPMID:25869668
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:19549681
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:12446704
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:11092755
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:8197185
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:9034150
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:14668490
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:26582200
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:23416069
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:25592972
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:24035762
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:27390154
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:17716972
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:17765678
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:19509052
Cellular ComponentGO:0005769early endosomeRab5aIDAMousePMID:24029230
Cellular ComponentGO:0005769early endosomeRab5al1IDARatPMID:25799061|RGD:11053432
Cellular ComponentGO:0005769early endosomeRab5aIDARatPMID:18353411|RGD:2306454
Cellular ComponentGO:0005769early endosomeRab5aIDARatPMID:25799061|RGD:11053432
Cellular ComponentGO:0032009early phagosomeRab5aIDAMouseMGI:MGI:6271154|PMID:25568335
Cellular ComponentGO:0030139endocytic vesicleRab5aIDAMousePMID:8197185
Cellular ComponentGO:0005768endosomeRab5aIDAMouseMGI:MGI:6271154|PMID:25568335
Cellular ComponentGO:0005768endosomeRab5aIDAMousePMID:22783020
Cellular ComponentGO:0005768endosomeRab5aIDAMousePMID:18794329
Cellular ComponentGO:0005768endosomeRab5al1IDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0005768endosomeRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0010008endosome membraneRAB5AIDAHumanPMID:15016378
Cellular ComponentGO:0010008endosome membraneRAB5AIDAHumanPMID:22431521
Cellular ComponentGO:0070062extracellular exosomeRAB5AHDAHumanPMID:20458337
Cellular ComponentGO:0098978glutamatergic synapseRab5al1IDARatPMID:15629704|RGD:155230721
Cellular ComponentGO:0098978glutamatergic synapseRab5al1IMPRatPMID:15629704|RGD:155230721
Cellular ComponentGO:0098978glutamatergic synapseRab5aIDARatPMID:15629704|RGD:155230721
Cellular ComponentGO:0098978glutamatergic synapseRab5aIMPRatPMID:15629704|RGD:155230721
Cellular ComponentGO:0043231intracellular membrane-bounded organelleRAB5AIDAHumanGO_REF:0000052
Cellular ComponentGO:0045121membrane raftRab5aIDAMousePMID:12388596
Cellular ComponentGO:0043005neuron projectionRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0043005neuron projectionRab5aIDARatPMID:8943215|RGD:2306448
Cellular ComponentGO:0043025neuronal cell bodyRab5al1IDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0043025neuronal cell bodyRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0005654nucleoplasmRAB5AIDAHumanGO_REF:0000052
Cellular ComponentGO:0048471perinuclear region of cytoplasmRab5aIDARatPMID:12703553|RGD:2306444
Cellular ComponentGO:0045335phagocytic vesicleRab5aIDAMouseMGI:MGI:6271154|PMID:25568335
Cellular ComponentGO:0045335phagocytic vesicleRab5aIDAMousePMID:22493499
Cellular ComponentGO:0005886plasma membraneRab5aIDAMousePMID:8197185
Cellular ComponentGO:0005886plasma membraneRab5aIDARatPMID:16154939|RGD:2306449
Cellular ComponentGO:0098842postsynaptic early endosomeRab5al1IDARatPMID:10930461|RGD:12050141
Cellular ComponentGO:0098842postsynaptic early endosomeRab5aIDARatPMID:10930461|RGD:12050141
Cellular ComponentGO:0098844postsynaptic endocytic zone membraneRab5al1IDARatPMID:15629704|RGD:155230721
Cellular ComponentGO:0098844postsynaptic endocytic zone membraneRab5al1IMPRatPMID:15629704|RGD:155230721
Cellular ComponentGO:0098844postsynaptic endocytic zone membraneRab5aIDARatPMID:15629704|RGD:155230721
Cellular ComponentGO:0098844postsynaptic endocytic zone membraneRab5aIMPRatPMID:15629704|RGD:155230721
Cellular ComponentGO:0032991protein-containing complexRab5aIDARatPMID:14709549|RGD:1359793
Cellular ComponentGO:0055037recycling endosomeRab5aIDARatPMID:10468577|RGD:4892345
Cellular ComponentGO:0001726ruffleRab5aIDAMousePMID:12446704
Cellular ComponentGO:0001726ruffleRab5aIDAMousePMID:21419809
Cellular ComponentGO:0036477somatodendritic compartmentRAB5AIDAHumanPMID:16141272
Cellular ComponentGO:0036477somatodendritic compartmentRab5al1IDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0036477somatodendritic compartmentRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0008021synaptic vesicleRab5al1IDARatPMID:17110340|RGD:12050113
Cellular ComponentGO:0008021synaptic vesicleRab5al1IDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0008021synaptic vesicleRab5aIDARatPMID:17110340|RGD:12050113
Cellular ComponentGO:0008021synaptic vesicleRab5aIDARatPMID:8043272|RGD:2306269
Cellular ComponentGO:0030672synaptic vesicle membraneRab5al1EXPRatPMID:20926670|RGD:13432355
Cellular ComponentGO:0030672synaptic vesicle membraneRab5al1IDARatPMID:20926670|RGD:13432355
Cellular ComponentGO:0030672synaptic vesicle membraneRab5al1IMPRatPMID:20926670|RGD:13432355
Cellular ComponentGO:0030672synaptic vesicle membraneRab5al1IDARatPMID:17110340|RGD:12050113
Cellular ComponentGO:0030672synaptic vesicle membraneRab5aEXPRatPMID:20926670|RGD:13432355
Cellular ComponentGO:0030672synaptic vesicle membraneRab5aIDARatPMID:20926670|RGD:13432355
Cellular ComponentGO:0030672synaptic vesicle membraneRab5aIMPRatPMID:20926670|RGD:13432355
Cellular ComponentGO:0030672synaptic vesicle membraneRab5aIDARatPMID:17110340|RGD:12050113
Cellular ComponentGO:0043195terminal boutonRAB5AIDAHumanPMID:16141272
Cellular ComponentGO:0043195terminal boutonRab5al1HDARatPMID:24876496|RGD:10047219
Cellular ComponentGO:0043195terminal boutonRab5aHDARatPMID:24876496|RGD:10047219
Cellular ComponentGO:0042589zymogen granule membraneRab5aIDARatPMID:8166729|RGD:2306267
Biological ProcessGO:0150093amyloid-beta clearance by transcytosisRAB5AIGIUniProtKB:Q07954HumanPMID:26005850
Biological ProcessGO:0045022early endosome to late endosome transportRAB5AIMPHumanPMID:17562788
Biological ProcessGO:0006897endocytosisRAB5AIDAHumanPMID:15378032
Biological ProcessGO:0006897endocytosisRab5aIDAMousePMID:8197185
Biological ProcessGO:0006897endocytosisRab5aIDAMousePMID:12446704
Biological ProcessGO:0006897endocytosisRab5aIMPRatPMID:16154939|RGD:2306449
Biological ProcessGO:0006897endocytosisrab5abIMPZFIN:ZDB-MRPHLNO-150409-2ZfishPMID:25478908
Biological ProcessGO:0007032endosome organizationRab5al1IMPRatPMID:8043272|RGD:2306269
Biological ProcessGO:0007032endosome organizationRab5aIMPRatPMID:8043272|RGD:2306269
Biological ProcessGO:0055113epiboly involved in gastrulation with mouth forming secondrab5abIMPZFIN:ZDB-MRPHLNO-150409-2ZfishPMID:25478908
Biological ProcessGO:0044788modulation by host of viral processRAB5AIMPHumanPMID:19376974
Biological ProcessGO:0038092nodal signaling pathwayrab5abIMPZFIN:ZDB-MRPHLNO-150409-2ZfishPMID:25478908
Biological ProcessGO:0045921positive regulation of exocytosisRAB5AIMPHumanPMID:19966785
Biological ProcessGO:0014911positive regulation of smooth muscle cell migrationRab5aIMPRatPMID:21125971|RGD:4892313
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationRab5aIMPRatPMID:21125971|RGD:4892313
Biological ProcessGO:0098884postsynaptic neurotransmitter receptor internalizationRab5al1IDARatPMID:15629704|RGD:155230721
Biological ProcessGO:0098884postsynaptic neurotransmitter receptor internalizationRab5al1IMPRatPMID:15629704|RGD:155230721
Biological ProcessGO:0098884postsynaptic neurotransmitter receptor internalizationRab5aIDARatPMID:15629704|RGD:155230721
Biological ProcessGO:0098884postsynaptic neurotransmitter receptor internalizationRab5aIMPRatPMID:15629704|RGD:155230721
Biological ProcessGO:2000286receptor internalization involved in canonical Wnt signaling pathwayRAB5AIMPHumanPMID:16890161
Biological ProcessGO:0051036regulation of endosome sizeRAB5AIMPHumanPMID:17562788
Biological ProcessGO:0051489regulation of filopodium assemblyRAB5AIDAHumanPMID:14978216
Biological ProcessGO:0048169regulation of long-term neuronal synaptic plasticityRab5aIMPRatPMID:18653660|RGD:2306450
Biological ProcessGO:2000300regulation of synaptic vesicle exocytosisRAB5AIMPHumanPMID:16141272
Biological ProcessGO:0060061Spemann organizer formationrab5abIMPZFIN:ZDB-MRPHLNO-150409-2ZfishPMID:25478908
Biological ProcessGO:0048488synaptic vesicle endocytosisRab5al1IDARatPMID:20956291|RGD:155230772
Biological ProcessGO:0048488synaptic vesicle endocytosisRab5al1IMPRatPMID:20956291|RGD:155230772
Biological ProcessGO:0048488synaptic vesicle endocytosisRab5aIDARatPMID:20956291|RGD:155230772
Biological ProcessGO:0048488synaptic vesicle endocytosisRab5aIMPRatPMID:20956291|RGD:155230772
Biological ProcessGO:0036465synaptic vesicle recyclingRAB5AIDAHumanPMID:16141272

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory