Rab5a
Gene Detail

Symbol Name ID

Rab5a RAB5A, member RAS oncogene family MGI:105926

Synonyms

2410015H04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

27.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:53479234-53507671 bp, + strand From Ensembl annotation of GRCm38   28438 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68142  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab5a

Human homologs

Human Homolog		RAB5A, RAB5A, member RAS oncogene family
NCBI Gene ID		5868
neXtProt AC		NX_P20339
Human Synonyms		RAB5
Human Chr (Location)		3p24-p22; chr3:19988572-20026667 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(1) Gene trapped(20)

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	cell differentiation, endocytosis, ...
Component	actin cytoskeleton, axon, ...
Function	GDP binding, GDP-dissociation inhibitor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 28

Assay Type	Results
Western blot	1

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(20) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000017831 (Evidence)
Entrez Gene	271457 (Evidence)
DFCI	TC1572967, TC1615320
NIA Mouse Gene Index	U018104
Consensus CDS Project	CCDS28879.1
International Mouse Knockout Project Status	Rab5a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000017831	Ensembl Gene Model | MGI Sequence Detail	28438	C57BL/6J
transcript	ENSMUST00000017975	Ensembl | MGI Sequence Detail	2357	Not Applicable
polypeptide	ENSMUSP00000017975	Ensembl | MGI Sequence Detail	215	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013633	ras-related protein Rab-5A

References

(Earliest) J:18627 Bucci C, et al., Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5061-5
(Latest) J:187732 Kawamura N, et al., Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012 Sep 18;3:1071
All references(61)

Other accession IDs

MGD-MRK-33604, MGI:1914237, MGI:2146915, MGI:2146988