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Rab5a
Gene Detail
 Symbol
Name
ID
Rab5a
RAB5A, member RAS oncogene family
MGI:105926
Synonyms 2410015H04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
27.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:53479234-53507671 bp, + strand
From Ensembl annotation of GRCm38

  28438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68142  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab5a

Human
homologs
Human Homolog RAB5A, RAB5A, member RAS oncogene family
NCBI Gene ID 5868
neXtProt AC  NX_P20339
Human Synonyms  RAB5
Human Chr (Location)  3p24-p22; chr3:19947080-19985175 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(20) Targeted(2)
Incidental mutations (data from Mutagenetix )
Interactions
Rab5a interacts with 263 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process cell differentiation, endocytosis, ...
Component actin cytoskeleton, axon, ...
Function GDP binding, GDP-dissociation inhibitor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 28
Assay TypeResults
Western blot 1
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000017831 (Evidence)
Entrez Gene271457 (Evidence)
DFCITC1572967, TC1615320
NIA Mouse Gene IndexU018104
Consensus CDS ProjectCCDS28879.1
International Mouse Knockout Project StatusRab5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017831 Ensembl Gene Model | MGI Sequence Detail 28438 C57BL/6J ±  kb
transcript ENSMUST00000017975 Ensembl | MGI Sequence Detail 2357 Not Applicable 
polypeptide ENSMUSP00000017975 Ensembl | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(127 from dbSNP Build 137)    SNPs within 2kb including multiple locations(167)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013633 ras-related protein Rab-5A
References (Earliest) J:18627 Bucci C, et al., Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5061-5
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(67)
Other
accession IDs
MGD-MRK-33604, MGI:1914237, MGI:2146915, MGI:2146988

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory