Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPRU
  • Mouse genes Ptpru
  • Rat genes Ptpru
  • Zfish genes ptprua,ptprub
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptpru

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	PTPRU	IPI	UniProtKB:P35222	Human	PMID:16574648
Molecular Function	GO:0008013	beta-catenin binding	Ptpru	IPI	UniProtKB:P35222	Mouse	PMID:9054423
Molecular Function	GO:0005515	protein binding	PTPRU	IPI	UniProtKB:P10721	Human	PMID:10397721
Molecular Function	GO:0005515	protein binding	PTPRU	IPI	UniProtKB:O00203	Human	PMID:17622474
Molecular Function	GO:0005515	protein binding	PTPRU	IPI	UniProtKB:O60493	Human	PMID:17622474
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRU	IDA		Human	PMID:12501215
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRU	IMP		Human	PMID:16574648
Cellular Component	GO:0005911	cell-cell junction	PTPRU	IDA		Human	PMID:12501215
Biological Process	GO:0031100	animal organ regeneration	Ptpru	IEP		Rat	PMID:7591957|RGD:1599982
Biological Process	GO:0034109	homotypic cell-cell adhesion	Ptpru	IDA		Mouse	PMID:9054423
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	PTPRU	IDA		Human	PMID:16574648
Biological Process	GO:0030336	negative regulation of cell migration	PTPRU	IDA		Human	PMID:12501215
Biological Process	GO:0030336	negative regulation of cell migration	PTPRU	IDA		Human	PMID:16574648
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTPRU	IDA		Human	PMID:16574648
Biological Process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	PTPRU	IDA		Human	PMID:16574648
Biological Process	GO:0006470	protein dephosphorylation	PTPRU	IDA		Human	PMID:12501215
Biological Process	GO:0034394	protein localization to cell surface	PTPRU	IDA		Human	PMID:16574648
Biological Process	GO:0051384	response to glucocorticoid	Ptpru	IEP		Rat	PMID:17457373|RGD:1642654
Biological Process	GO:0001757	somite specification	ptprub	IMP		Zfish	PMID:15226256

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern