About   Help   FAQ
Ptpru
Gene Detail
Symbol

Name
ID
Ptpru
protein tyrosine phosphatase, receptor type, U
MGI:1321151
Synonyms
Ptprl, RPTPlambda
Feature Type
protein coding gene
Genetic Map
Chromosome 4
64.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:131768457-131838288 bp, - strand
From VEGA annotation of GRCm38

  69832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTPRU
Protein SuperFamily: receptor tyrosine-protein phosphatase, kappa/mu/T/U types
Gene Tree: Ptpru

Human
homologs
PTPRU, protein tyrosine phosphatase, receptor type, U
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10076
neXtProt AC: NX_Q92729

Human Synonyms: FMI, hPTP-J, PCP-2, PTP, PTP-J, PTP-PI, PTPPSI, PTPRO, PTP-RO, PTPU2, R-PTP-PSI, R-PTP-U

Human Chr (Location): 1p35.3; chr1:29236516-29326813 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Genomic Mutations involving Ptpru (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ptpru interacts with 184 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process canonical Wnt signaling pathway, cell adhesion, ...
Component cell-cell junction, cell junction, ...
Function beta-catenin binding, hydrolase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (190)    Tissues (155)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 150
Northern blot 36
Western blot 1
RT-PCR 3
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PTPRU ; Xenbase ptpru    NEW 
Molecular
reagents
All nucleic(82) Genomic(1) cDNA(76) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009567 (Evidence)
Ensembl Gene Model ENSMUSG00000028909 (Evidence)
Entrez Gene 19273 (Evidence)
UniGene 4860
DFCI TC1577240, TC1596746, TC1698982
DoTS DT.101145365, DT.101138543, DT.55201743, DT.480896, DT.101738851, DT.94287747
NIA Mouse Gene Index U025584
EC 3.1.3.48
Consensus CDS Project CCDS18714.1, CCDS38896.1
International Mouse Phenotyping Consortium Status Ptpru
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009567 VEGA Gene Model | MGI Sequence Detail 69832 C57BL/6J ±  kb
transcript OTTMUST00000021931 VEGA | MGI Sequence Detail 4416 Not Applicable 
polypeptide OTTMUSP00000010000 VEGA | MGI Sequence Detail 1446 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(32) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(860 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR000998 MAM domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013481 receptor-type tyrosine-protein phosphatase U
References
(Earliest) J:37785 Avraham S, et al., Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. Gene. 1997 Dec 19;204(1-2):5-16
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(43)
Other
accession IDs
MGD-MRK-39493, MGI:109494

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory