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Ptpru Gene Detail
Summary
  • Symbol
    Ptpru
  • Name
    protein tyrosine phosphatase, receptor type, U
  • Synonyms
    Ptprl, RPTPlambda
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321151
    NCBI Gene: 19273
  • Gene Overview
    MyGene.info: PTPRU
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131768457-131838288 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 64.50 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    859 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321151
protein coding gene Chr4:131768457-131838314 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028857
protein coding gene Chr4:133864800-133942517 (-)
A/J MGP_AJ_G0028816
protein coding gene Chr4:128311116-128382797 (-)
AKR/J MGP_AKRJ_G0028769
protein coding gene Chr4:131902889-131976236 (-)
BALB/cJ MGP_BALBcJ_G0028839
protein coding gene Chr4:128925930-128997420 (-)
C3H/HeJ MGP_C3HHeJ_G0028553
protein coding gene Chr4:132155043-132229797 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029281
protein coding gene Chr4:138686432-138761559 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026553
protein coding gene Chr4:121405443-121476684 (-)
CAST/EiJ MGP_CASTEiJ_G0027986
protein coding gene Chr4:130209626-130293712 (-)
CBA/J MGP_CBAJ_G0028519
protein coding gene Chr4:142220085-142300164 (-)
DBA/2J MGP_DBA2J_G0028668
protein coding gene Chr4:128736925-128807209 (-)
FVB/NJ MGP_FVBNJ_G0028635
protein coding gene Chr4:127584959-127654542 (-)
LP/J MGP_LPJ_G0028769
protein coding gene Chr4:134024108-134099062 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028661
protein coding gene Chr4:146876454-146951020 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029319
protein coding gene Chr4:132296970-132369706 (-)
PWK/PhJ MGP_PWKPhJ_G0027707
protein coding gene Chr4:125403358-125476279 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027533
protein coding gene Chr4:128178128-128252923 (-)
WSB/EiJ MGP_WSBEiJ_G0028066
protein coding gene Chr4:132474186-132546405 (-)



Homology
more
  • Human Ortholog
    PTPRU, protein tyrosine phosphatase, receptor type U
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPRU, protein tyrosine phosphatase, receptor type U
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FMI, hPTP-J, PCP-2, PTP, PTP-J, PTP-PI, PTPPSI, PTPRO, PTP-RO, PTPU2, R-PTP-PSI, R-PTP-U
  • Links
    NCBI Gene ID: 10076
    neXtProt AC: NX_Q92729
    UniProt: Q92729

  • Chr Location
    1p35.3; chr1:29236516-29326813 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028909 Ensembl Gene Model | MGI Sequence Detail 69832 C57BL/6J ±  kb
transcript ENSMUST00000030741 Ensembl | MGI Sequence Detail 4416 Not Applicable  
polypeptide ENSMUSP00000030741 Ensembl | MGI Sequence Detail 1446 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    Genomic 1
    cDNA 77
    Primer pair 3
    Other 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-39493, MGI:109494
References
more
  • Summaries
    All 50
    Developmental Gene Expression 15
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:37785 Avraham S, et al., Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. Gene. 1997 Dec 19;204(1-2):5-16
  • Latest
    J:245526 Bibollet-Bahena O, et al., A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory