Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKAR2B
  • Mouse genes Prkar2b
  • Rat genes Prkar2b
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkar2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030552	cAMP binding	Prkar2b	IDA		Rat	PMID:11907174|RGD:2312572
Molecular Function	GO:0030552	cAMP binding	Prkar2b	IDA		Rat	PMID:14625280|RGD:2312570
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	PRKAR2B	IDA		Human	PMID:21812984
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	PRKAR2B	IDA		Human	PMID:21812984
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar2b	IDA		Mouse	PMID:7775586
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar2b	IDA		Rat	PMID:11907174|RGD:2312572
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Prkar2b	IDA		Rat	PMID:16816331|RGD:2312556
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:17148597
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P13861,UniProtKB:P49841,UniProtKB:Q9P0R6	Human	PMID:20007971
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P13861,UniProtKB:Q9P0R6	Human	PMID:20007971
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:24605759
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:25477193
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P13861,UniProtKB:Q9P0R6	Human	PMID:25920809
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:A0A0S2Z4Y8	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:A0A0S2Z551	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:A0A0S2Z5D3	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P24588	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:Q86UN6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:O43687-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P24588	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P33176	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:Q16514	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:Q16610	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:Q86UN6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:Q9BSF0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PRKAR2B	IPI	UniProtKB:P17612	Human	PMID:33058759
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:P05132	Mouse	MGI:MGI:5919049|PMID:26158466
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:O70585	Mouse	MGI:MGI:3722528|PMID:17610895
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:P05132	Mouse	MGI:MGI:5919565|PMID:26278174
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:P05132	Mouse	MGI:MGI:5919473|PMID:22323819
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:P05132	Mouse	MGI:MGI:5004728|PMID:21614075
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:P05132|UniProtKB:Q5S006	Mouse	MGI:MGI:5553024|PMID:24464040
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:D4A772|UniProtKB:P84060	Rat	PMID:17610895|RGD:126781731
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:P17612	Rat	PMID:24464040|RGD:8553364
Molecular Function	GO:0005515	protein binding	Prkar2b	IPI	UniProtKB:Q5S007	Rat	PMID:24464040|RGD:8553364
Molecular Function	GO:0019904	protein domain specific binding	Prkar2b	IDA		Rat	PMID:16996504|RGD:2312601
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR2B	IPI	UniProtKB:P17612-1	Human	PMID:21812984
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PRKAR2B	IPI	UniProtKB:P17612-2	Human	PMID:21812984
Molecular Function	GO:0019901	protein kinase binding	Prkar2b	IPI	UniProtKB:Q5S006|UniProtKB:Q5S007	Mouse	MGI:MGI:5553024|PMID:24464040
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PRKAR2B	IDA		Human	PMID:21423175
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar2b	IDA		Mouse	PMID:21502359
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar2b	IDA		Rat	PMID:11907174|RGD:2312572
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	Prkar2b	IDA		Rat	PMID:16816331|RGD:2312556
Cellular Component	GO:0005813	centrosome	PRKAR2B	IDA		Human	PMID:21399614
Cellular Component	GO:0097546	ciliary base	Prkar2b	IDA		Mouse	PMID:22007132
Cellular Component	GO:0005737	cytoplasm	PRKAR2B	IDA		Human	PMID:21423175
Cellular Component	GO:0005737	cytoplasm	Prkar2b	IDA		Mouse	PMID:21502359
Cellular Component	GO:0005737	cytoplasm	Prkar2b	IDA		Rat	PMID:18550536|RGD:2312619
Cellular Component	GO:0030425	dendrite	Prkar2b	IDA		Rat	PMID:10618500|RGD:631929
Cellular Component	GO:0043198	dendritic shaft	Prkar2b	IDA		Mouse	MGI:MGI:5553024|PMID:24464040
Cellular Component	GO:0043197	dendritic spine	Prkar2b	IDA		Mouse	MGI:MGI:5553024|PMID:24464040
Cellular Component	GO:0070062	extracellular exosome	PRKAR2B	HDA		Human	PMID:23533145
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2b	IMP		Mouse	PMID:19447092
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2b	IDA		Mouse	PMID:19447092
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2b	IDA		Mouse	PMID:15483123
Cellular Component	GO:0098978	glutamatergic synapse	Prkar2b	IMP		Mouse	PMID:15483123
Cellular Component	GO:0045121	membrane raft	Prkar2b	IDA		Rat	PMID:12573460|RGD:2312526
Cellular Component	GO:0043025	neuronal cell body	Prkar2b	IDA		Rat	PMID:10618500|RGD:631929
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Prkar2b	IDA		Rat	PMID:18550536|RGD:2312619
Cellular Component	GO:0005886	plasma membrane	PRKAR2B	IDA		Human	PMID:21423175
Cellular Component	GO:0098794	postsynapse	Prkar2b	IDA		Mouse	PMID:19447092
Cellular Component	GO:0098794	postsynapse	Prkar2b	IMP		Mouse	PMID:19447092
Cellular Component	GO:0098794	postsynapse	Prkar2b	IDA		Mouse	PMID:24464040
Cellular Component	GO:0098794	postsynapse	Prkar2b	IDA		Rat	PMID:19447092|RGD:12050092
Biological Process	GO:0006631	fatty acid metabolic process	Prkar2b	IMP	MGI:MGI:2158642	Mouse	PMID:8757131
Biological Process	GO:0007612	learning	Prkar2b	IMP	MGI:MGI:2158642	Mouse	PMID:9570795
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Prkar2b	IDA		Mouse	PMID:15483123
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Prkar2b	IMP		Mouse	PMID:15483123
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	PRKAR2B	IDA		Human	PMID:21812984
Biological Process	GO:0045859	regulation of protein kinase activity	Prkar2b	IDA		Rat	PMID:11907174|RGD:2312572
Biological Process	GO:0045859	regulation of protein kinase activity	Prkar2b	IDA		Rat	PMID:16816331|RGD:2312556
Biological Process	GO:0097332	response to antipsychotic drug	Prkar2b	IEP		Rat	PMID:11907174|RGD:2312572
Biological Process	GO:0097338	response to clozapine	Prkar2b	IEP		Rat	PMID:11907174|RGD:2312572

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern