Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRG4
  • Mouse genes Prg4
  • Rat genes Prg4
  • Zfish genes prg4a,prg4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prg4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PRG4	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PRG4	HDA		Human	PMID:25037231
Cellular Component	GO:0005615	extracellular space	Prg4	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Prg4	IDA		Mouse	PMID:15719068
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Prg4	IMP	MGI:MGI:3513195	Mouse	PMID:21939632
Biological Process	GO:0032635	interleukin-6 production	Prg4	IMP	MGI:MGI:3513195	Mouse	PMID:21939632
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Prg4	IMP	MGI:MGI:3513195	Mouse	PMID:21939632
Biological Process	GO:0042127	regulation of cell population proliferation	Prg4	IMP	MGI:MGI:3513195	Mouse	PMID:15719068

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern