Prg4
Gene Detail

Symbol Name ID

Prg4 proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) MGI:1891344

Synonyms

DOL54, lubricin, MSF, SZP

Feature Type

protein coding gene

Genetic Map

Chromosome 1

63.84 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:150449816-150466165 bp, - strand From VEGA annotation of GRCm38   16350 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:130465  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 zebrafish

Gene Tree: Prg4

Human homologs

Human Homolog		PRG4, proteoglycan 4
NCBI Gene ID		10216
neXtProt AC		NX_Q92954
Human Synonyms		bG174L6.2, CACP, HAPO, JCAP, MSF, SZP
Human Chr (Location)		1q25-q31; chr1:186265405-186283688 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRG4

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Aging homozygous null mice develop a hopping gait, irregular endochondral growth plates, altered cartilage surface, camptodactyly, progressive synovial hyperplasia and, ultimately, joint failure.

 
Human Diseases Modeled Using Mouse Prg4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	hematopoietic stem cell proliferation, immune response, ...
Component	extracellular region, extracellular space
Function	polysaccharide binding, scavenger receptor activity

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (36)    Tissues (10)    Images (25)
Theiler Stages: 23, 26

Assay Type	Results
RNA in situ	36

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(6) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033522 (Evidence)
Ensembl Gene Model	ENSMUSG00000006014 (Evidence)
Entrez Gene	96875 (Evidence)
DFCI	TC1588613, TC1665832
DoTS	DT.101135951, DT.101394913, DT.40184387, DT.99854578
NIA Mouse Gene Index	U021875
Consensus CDS Project	CCDS48391.1, CCDS48392.1
International Mouse Knockout Project Status	Prg4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033522	VEGA Gene Model | MGI Sequence Detail	16350	C57BL/6J
transcript	OTTMUST00000084349	VEGA | MGI Sequence Detail	3821	Not Applicable
polypeptide	OTTMUSP00000045445	VEGA | MGI Sequence Detail	1221	Not Applicable

All sequences(52) RefSeq(4) UniProt(7)

Protein-related information

Resource	ID	Description
InterPro	IPR003302	Cornifin (SPRR1)
InterPro	IPR018486	Hemopexin, conserved site
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR020436	Somatomedin B, chordata
InterPro	IPR001212	Somatomedin B domain
Protein Ontology	PR:000013208	proteoglycan 4

References

(Earliest) J:75732 Kuroda M, et al., Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5025-30
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(40)