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Prg4
Gene Detail
Symbol

Name
ID
Prg4
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
MGI:1891344
Synonyms
DOL54, lubricin, MSF, SZP
Feature Type
protein coding gene
Genetic Map
Chromosome 1
63.84 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:150449816-150466165 bp, - strand
From VEGA annotation of GRCm38

  16350 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137352  Vertebrate Homology Class
1 mouse; 1 dog

HCOP human homology predictions: PRG4
Gene Tree: Prg4

Human
homologs
PRG4, proteoglycan 4
Orthology source: HGNC

IDs:
NCBI Gene ID: 10216
neXtProt AC: NX_Q92954

Human Synonyms: CACP, HAPO, JCAP, MSF, SZP

Human Chr (Location): 1q25-q31; chr1:186296273-186314562 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRG4

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Aging homozygous null mice develop a hopping gait, irregular endochondral growth plates, altered cartilage surface, camptodactyly, progressive synovial hyperplasia and, ultimately, joint failure.
 
Human Diseases Modeled in Mice Using Prg4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Prg4 interacts with 144 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process hematopoietic stem cell proliferation, immune response, ...
Component extracellular region, extracellular space
Function polysaccharide binding, scavenger receptor activity
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (36)    Tissues (10)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prg4    NEW 
Molecular
reagents
All nucleic(7) cDNA(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033522 (Evidence)
Ensembl Gene Model ENSMUSG00000006014 (Evidence)
Entrez Gene 96875 (Evidence)
DFCI TC1588613, TC1665832
DoTS DT.101135951, DT.101394913, DT.40184387, DT.99854578
NIA Mouse Gene Index U021875
Consensus CDS Project CCDS48391.1, CCDS48392.1
International Mouse Phenotyping Consortium Status Prg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033522 VEGA Gene Model | MGI Sequence Detail 16350 C57BL/6J ±  kb
transcript OTTMUST00000084349 VEGA | MGI Sequence Detail 3821 Not Applicable 
polypeptide OTTMUSP00000045445 VEGA | MGI Sequence Detail 1221 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(223 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003302 Cornifin (SPRR1)
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR020436 Somatomedin B, chordata
InterPro IPR001212 Somatomedin B domain
Protein Ontology PR:000013208 proteoglycan 4
References
(Earliest) J:75732 Kuroda M, et al., Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5025-30
(Latest) J:207489 Ogawa H, et al., Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes Dev. 2014 Jan 15;28(2):127-39
All references(45)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory