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Prg4 Gene Detail
Summary
  • Symbol
    Prg4
  • Name
    proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
  • Synonyms
    DOL54, lubricin, MSF, SZP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891344
    NCBI Gene: 96875
  • Gene Overview
    MyGene.info: PRG4
Location & Maps
more
  • Sequence Map
    Chr1:150449816-150466165 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16350 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 63.84 cM, cytoband G
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRG4, proteoglycan 4
  • Vertebrate Orthologs
    2
  • Human Ortholog
    PRG4, proteoglycan 4
    Orthology source: HGNC
  • Synonyms
    CACP, HAPO, JCAP, MSF, SZP
  • Links
    NCBI Gene ID: 10216
    neXtProt AC: NX_Q92954

  • Chr Location
    1q25-q31; chr1:186296273-186314562 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Prg4 mouse models; 1 with human PRG4 associations

Human Disease Mouse Models
       Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome; CACP   OMIM: 208250 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    2 involving Prg4
  • Incidental Mutations
Aging homozygous null mice develop a hopping gait, irregular endochondral growth plates, altered cartilage surface, camptodactyly, progressive synovial hyperplasia and, ultimately, joint failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033522 VEGA Gene Model | MGI Sequence Detail 16350 C57BL/6J ±  kb
transcript OTTMUST00000084349 VEGA | MGI Sequence Detail 3821 Not Applicable  
polypeptide OTTMUSP00000045445 VEGA | MGI Sequence Detail 1221 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    209 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:75732 Kuroda M, et al., Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5025-30
  • Latest
    J:223424 Hill A, et al., Lubricin protects the temporomandibular joint surfaces from degeneration. PLoS One. 2014;9(9):e106497

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory