Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDM8
  • Mouse genes Prdm8
  • Rat genes Prdm8
  • Zfish genes prdm8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdm8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Prdm8	IDA		Mouse	PMID:22284184
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	Prdm8	IDA		Mouse	PMID:19646955
Molecular Function	GO:0042054	histone methyltransferase activity	Prdm8	IDA		Mouse	PMID:19646955
Molecular Function	GO:0005515	protein binding	PRDM8	IPI	UniProtKB:O95278,UniProtKB:Q6VVB1	Human	PMID:22961547
Molecular Function	GO:0005515	protein binding	Prdm8	IPI	PR:Q8C6A8	Mouse	PMID:22284184
Molecular Function	GO:0003714	transcription corepressor activity	Prdm8	IMP	MGI:MGI:5315763	Mouse	PMID:22284184
Cellular Component	GO:0016604	nuclear body	PRDM8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PRDM8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PRDM8	IDA		Human	PMID:22961547
Cellular Component	GO:0005634	nucleus	Prdm8	IDA		Mouse	PMID:19646955
Cellular Component	GO:0005634	nucleus	Prdm8	IDA		Mouse	PMID:22284184
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	Prdm8	IMP	MGI:MGI:5315763	Mouse	PMID:22284184
Biological Process	GO:0021540	corpus callosum morphogenesis	Prdm8	IMP	MGI:MGI:5315763	Mouse	PMID:22284184
Biological Process	GO:0021957	corticospinal tract morphogenesis	Prdm8	IMP	MGI:MGI:5315763	Mouse	PMID:22284184
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Prdm8	IDA		Mouse	PMID:19646955
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Prdm8	IMP	MGI:MGI:5315763	Mouse	PMID:22284184
Biological Process	GO:0022008	neurogenesis	Prdm8	IDA		Mouse	PMID:19050759

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern