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Prdm8
Gene Detail
Symbol

Name
ID
Prdm8
PR domain containing 8
MGI:1924880
Feature Type
protein coding gene
Genetic Map
Chromosome 5
47.77 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:98180869-98187448 bp, + strand
From NCBI annotation of GRCm38

  6580 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Prdm8

Human
homologs
Human Homolog PRDM8, PR domain containing 8
NCBI Gene ID 56978
neXtProt AC  NX_Q9NQV8
Human Synonyms  PFM5
Human Chr (Location)  4q21; chr4:80183879-80204329 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit premature termination of corticopsinal motor neuron axons, absent corpus callosum and hippocampal commissure, excessive scratching, skin lesions, and contraction of hindpaws resulting a handstand phenotype.
 
Interactions
Prdm8 interacts with 207 markers (Mir10a, Mir17, Mir20a, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (229)    Tissues (72)    Images (110)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 78
RNA in situ 125
Northern blot 12
RT-PCR 14
cDNA source data(8)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(9) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035456 (Evidence)
Entrez Gene77630 (Evidence)
UniGene332511
DoTSDT.101722469, DT.60103579, DT.94133769
EC2.1.1.-
Consensus CDS ProjectCCDS39178.1
International Mouse Knockout Project StatusPrdm8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 77630 NCBI Gene Model | MGI Sequence Detail 6580 C57BL/6J ±  kb
transcript NM_029947 RefSeq | MGI Sequence Detail 3119 C57BL/6 
polypeptide Q8BZ97 UniProt | EBI | MGI Sequence Detail 687 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000013189 PR domain zinc finger protein 8
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory