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Prdm8 Gene Detail
Summary
  • Symbol
    Prdm8
  • Name
    PR domain containing 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924880
    NCBI Gene: 77630
  • Gene Overview
    MyGene.info: PRDM8
Location & Maps
more
  • Sequence Map
    Chr5:98167198-98188991 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21794 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.77 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRDM8, PR/SET domain 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRDM8, PR/SET domain 8
    Orthology source: HomoloGene
  • Synonyms
    EPM10, PFM5
  • Links
    NCBI Gene ID: 56978
    neXtProt AC: NX_Q9NQV8

  • Chr Location
    4q21; chr4:80183741-80204329 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PRDM8 associations

Human Disease Mouse Models
       Epilepsy, Progressive Myoclonic, 10; EPM10   OMIM: 616640
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Prdm8
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit premature termination of corticopsinal motor neuron axons, absent corpus callosum and hippocampal commissure, excessive scratching, skin lesions, and contraction of hindpaws resulting a handstand phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053329 VEGA Gene Model | MGI Sequence Detail 21794 C57BL/6J ±  kb
transcript OTTMUST00000148309 VEGA | MGI Sequence Detail 3316 Not Applicable  
polypeptide OTTMUSP00000077108 VEGA | MGI Sequence Detail 688 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    117 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 14
    cDNA 9
    Primer pair 3
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:223395 Jung CC, et al., Transcription factor PRDM8 is required for rod bipolar and type 2 OFF-cone bipolar cell survival and amacrine subtype identity. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3010-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory