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Prdm8
Gene Detail
Symbol

Name
ID
Prdm8
PR domain containing 8
MGI:1924880
Feature Type
protein coding gene
Genetic Map
Chromosome 5
47.77 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:98180869-98187448 bp, + strand
From Ensembl annotation of GRCm38

  6580 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRDM8
Gene Tree: Prdm8

Human
homologs
PRDM8, PR domain containing 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56978
neXtProt AC: NX_Q9NQV8

Human Synonyms: PFM5

Human Chr (Location): 4q21; chr4:80183741-80204329 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit premature termination of corticopsinal motor neuron axons, absent corpus callosum and hippocampal commissure, excessive scratching, skin lesions, and contraction of hindpaws resulting a handstand phenotype.
 
Interactions
Prdm8 interacts with 207 markers (Mir10a, Mir17, Mir20a, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (229)    Tissues (72)    Images (110)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 78
RNA in situ 125
Northern blot 12
RT-PCR 14
cDNA source data(8)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase prdm8 ; ZFIN prdm8b    NEW 
Molecular
reagents
All nucleic(14) cDNA(9) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000035456 (Evidence)
Entrez Gene 77630 (Evidence)
UniGene 332511
DoTS DT.94133769, DT.60103579, DT.101722469
EC 2.1.1.-
Consensus CDS Project CCDS39178.1
International Mouse Phenotyping Consortium Status Prdm8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035456 Ensembl Gene Model | MGI Sequence Detail 6580 C57BL/6J ±  kb
transcript ENSMUST00000112959 Ensembl | MGI Sequence Detail 3119 Not Applicable 
polypeptide ENSMUSP00000108583 Ensembl | MGI Sequence Detail 688 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000013189 PR domain zinc finger protein 8
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212695 Inoue M, et al., Prdm8 regulates the morphological transition at multipolar phase during neocortical development. PLoS One. 2014;9(1):e86356
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory