Prdm8
Gene Detail

Symbol Name ID

Prdm8 PR domain containing 8 MGI:1924880

Feature Type

protein coding gene

Genetic Map

Chromosome 5

47.77 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:98180869-98187448 bp, + strand From NCBI annotation of GRCm38   6580 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:129760  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 zebrafish

Gene Tree: Prdm8

Human homologs

Human Homolog		PRDM8, PR domain containing 8
NCBI Gene ID		56978
neXtProt AC		NX_Q9NQV8
Human Synonyms		PFM5
Human Chr (Location)		4q21; chr4:81106424-81125483 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit premature termination of corticopsinal motor neuron axons, absent corpus callosum and hippocampal commissure, excessive scratching, skin lesions, and contraction of hindpaws resulting a handstand phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	central nervous system projection neuron axonogenesis, corpus callosum morphogenesis, ...
Component	histone methyltransferase complex, nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (229)    Tissues (69)    Images (110)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	78
RNA in situ	125
Northern blot	12
RT-PCR	14

cDNA source data(8)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(9) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035456 (Evidence)
Entrez Gene	77630 (Evidence)
UniGene	332511
DoTS	DT.101722469, DT.60103579, DT.94133769
Consensus CDS Project	CCDS39178.1
International Mouse Knockout Project Status	Prdm8

Sequences

Length	Strain/Species
genomic	77630	NCBI Gene Model | MGI Sequence Detail	6580	C57BL/6J
transcript	NM_029947	RefSeq | MGI Sequence Detail	3119	C57BL/6
polypeptide	Q8BZ97	UniProt | EBI | MGI Sequence Detail	687	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001214	SET domain
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000013189	PR domain zinc finger protein 8

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182304 Ross SE, et al., Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron. 2012 Jan 26;73(2):292-303
All references(31)