Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRDM4
  • Mouse genes Prdm4
  • Rat genes Prdm4
  • Zfish genes prdm4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prdm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005123	death receptor binding	Prdm4	IPI	RGD:3177	Rat	PMID:10485890|RGD:633619
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Prdm4	IMP		Mouse	MGI:MGI:5543872|PMID:23918801
Molecular Function	GO:1990226	histone methyltransferase binding	Prdm4	IPI	UniProtKB:Q8CIG8	Mouse	MGI:MGI:5645199|PMID:23048031
Molecular Function	GO:0005515	protein binding	PRDM4	IPI	UniProtKB:Q8IXL7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRDM4	IPI	UniProtKB:Q8WYA6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PRDM4	IPI	UniProtKB:P62166	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PRDM4	IPI	UniProtKB:P46934	Human	PMID:35044719
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Prdm4	IMP		Mouse	MGI:MGI:5543872|PMID:23918801
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PRDM4	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Prdm4	IDA		Mouse	MGI:MGI:5645199|PMID:23048031
Cellular Component	GO:0005737	cytoplasm	Prdm4	IDA		Rat	PMID:10485890|RGD:633619
Cellular Component	GO:0035097	histone methyltransferase complex	Prdm4	IPI	UniProtKB:Q8CIG8	Mouse	MGI:MGI:5645199|PMID:23048031
Cellular Component	GO:0005634	nucleus	Prdm4	IDA		Mouse	MGI:MGI:5645199|PMID:23048031
Cellular Component	GO:0005634	nucleus	Prdm4	IDA		Rat	PMID:10485890|RGD:633619
Biological Process	GO:0071363	cellular response to growth factor stimulus	Prdm4	IEP		Rat	PMID:10485890|RGD:633619
Biological Process	GO:0031670	cellular response to nutrient	Prdm4	IEP		Rat	PMID:10485890|RGD:633619
Biological Process	GO:0030308	negative regulation of cell growth	Prdm4	IDA		Rat	PMID:10485890|RGD:633619
Biological Process	GO:0010629	negative regulation of gene expression	Prdm4	IMP		Rat	PMID:23048031|RGD:10054084
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Prdm4	IMP		Mouse	MGI:MGI:5543872|PMID:23918801
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	Prdm4	IMP		Rat	PMID:23048031|RGD:10054084
Biological Process	GO:2000736	regulation of stem cell differentiation	Prdm4	IMP		Rat	PMID:23048031|RGD:10054084

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern