Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPM1D
  • Mouse genes Ppm1d
  • Rat genes Ppm1d
  • Zfish genes ppm1da,ppm1db
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppm1d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	PPM1D	IPI	UniProtKB:Q16539	Human	PMID:21283629
Molecular Function	GO:0005515	protein binding	PPM1D	IPI	UniProtKB:Q00987	Human	PMID:17936559
Molecular Function	GO:0005515	protein binding	PPM1D	IPI	UniProtKB:P16104	Human	PMID:20118229
Molecular Function	GO:0005515	protein binding	PPM1D	IPI	UniProtKB:Q13950	Human	PMID:22065775
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	PPM1D	IDA		Human	PMID:20801214
Cellular Component	GO:0005829	cytosol	PPM1D	IDA		Human	PMID:28343630
Cellular Component	GO:0005730	nucleolus	PPM1D	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PPM1D	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PPM1D	IDA		Human	PMID:28343630
Biological Process	GO:0009267	cellular response to starvation	Ppm1d	IEP		Rat	PMID:23520533|RGD:8693590
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	Ppm1d	IDA		Mouse	PMID:21522133
Biological Process	GO:0006306	DNA methylation	Ppm1d	IDA		Mouse	MGI:MGI:5551345|PMID:24135283
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Ppm1d	IMP	MGI:MGI:2179128	Mouse	PMID:11809801
Biological Process	GO:0031507	heterochromatin formation	Ppm1d	IDA		Mouse	MGI:MGI:5551345|PMID:24135283
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	PPM1D	IMP		Human	PMID:23242139
Biological Process	GO:0035970	peptidyl-threonine dephosphorylation	PPM1D	IDA		Human	PMID:20801214
Biological Process	GO:0009617	response to bacterium	Ppm1d	IMP	MGI:MGI:2179128	Mouse	PMID:11809801

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern