Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLEKHM1
  • Mouse genes Plekhm1
  • Rat genes Plekhm1
  • Zfish genes plekhm1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plekhm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:A0A0D6GID3	Human	PMID:25500191
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:O95166	Human	PMID:25500191
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P18067	Human	PMID:25500191
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P49754	Human	PMID:25500191
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P51149	Human	PMID:27291868
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P49754	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P49754|UniProtKB:Q96AX1|UniProtKB:Q9H270|UniProtKB:Q9P253	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P51149	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:Q96BM9	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:Q96JC1	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:Q9NVJ2	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:O95166	Human	PMID:33452816
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P18067	Human	PMID:33452816
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P42345	Human	PMID:33452816
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P49754	Human	PMID:33452816
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:P51149	Human	PMID:33452816
Molecular Function	GO:0005515	protein binding	PLEKHM1	IPI	UniProtKB:Q96JC1	Human	PMID:33452816
Molecular Function	GO:0005515	protein binding	Plekhm1	IPI	UniProtKB:P51150|UniProtKB:Q3TJZ6|UniProtKB:Q62073|UniProtKB:Q99J78|UniProtKB:Q9ERR1	Mouse	MGI:MGI:5806241|PMID:27777970
Molecular Function	GO:0005515	protein binding	Plekhm1	IPI	PR:P63005	Mouse	PMID:22073305
Cellular Component	GO:0044754	autolysosome	PLEKHM1	IDA		Human	PMID:28325809
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PLEKHM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	PLEKHM1	IDA		Human	PMID:28325809
Cellular Component	GO:0005730	nucleolus	PLEKHM1	IDA		Human	GO_REF:0000052
Biological Process	GO:0061909	autophagosome-lysosome fusion	PLEKHM1	IMP		Human	PMID:28325809
Biological Process	GO:1902774	late endosome to lysosome transport	PLEKHM1	IMP		Human	PMID:28325809
Biological Process	GO:0032418	lysosome localization	PLEKHM1	IDA		Human	PMID:28325809
Biological Process	GO:0032418	lysosome localization	Plekhm1	IMP		Mouse	MGI:MGI:5806241|PMID:27777970
Biological Process	GO:0045780	positive regulation of bone resorption	Plekhm1	IMP		Mouse	MGI:MGI:5806241|PMID:27777970
Biological Process	GO:1900029	positive regulation of ruffle assembly	Plekhm1	IMP		Mouse	MGI:MGI:5806241|PMID:27777970

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern