Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLEKHA1
  • Mouse genes Plekha1
  • Rat genes Plekha1
  • Zfish genes plekha1a,plekha1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plekha1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030165	PDZ domain binding	PLEKHA1	IPI	UniProtKB:O75970	Human	PMID:11802782
Molecular Function	GO:0030165	PDZ domain binding	PLEKHA1	IPI	UniProtKB:Q12923	Human	PMID:14516276
Molecular Function	GO:0030165	PDZ domain binding	PLEKHA1	IPI	UniProtKB:Q9NSN8	Human	PMID:15485858
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	PLEKHA1	IDA		Human	PMID:11001876
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	PLEKHA1	IDA		Human	PMID:17823121
Molecular Function	GO:0005515	protein binding	PLEKHA1	IPI	UniProtKB:O75970	Human	PMID:11802782
Molecular Function	GO:0005515	protein binding	PLEKHA1	IPI	UniProtKB:Q9P0V3	Human	PMID:18654987
Cellular Component	GO:0005737	cytoplasm	PLEKHA1	IDA		Human	PMID:12101241
Cellular Component	GO:0005737	cytoplasm	PLEKHA1	IDA		Human	PMID:14516276
Cellular Component	GO:0005829	cytosol	PLEKHA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	PLEKHA1	HDA		Human	PMID:19056867
Cellular Component	GO:0005654	nucleoplasm	PLEKHA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PLEKHA1	IDA		Human	PMID:12101241
Cellular Component	GO:0005886	plasma membrane	PLEKHA1	IDA		Human	PMID:14516276
Cellular Component	GO:0032587	ruffle membrane	PLEKHA1	IDA		Human	PMID:12101241
Biological Process	GO:0008209	androgen metabolic process	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:19056881
Biological Process	GO:0050853	B cell receptor signaling pathway	PLEKHA1	IDA		Human	PMID:12101241
Biological Process	GO:0070301	cellular response to hydrogen peroxide	PLEKHA1	IDA		Human	PMID:14516276
Biological Process	GO:0045184	establishment of protein localization	PLEKHA1	IDA		Human	PMID:14516276
Biological Process	GO:0008210	estrogen metabolic process	Plekha1	IGI	MGI:MGI:97530	Mouse	PMID:19056881
Biological Process	GO:0060325	face morphogenesis	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:17143286
Biological Process	GO:0008585	female gonad development	Plekha1	IGI	MGI:MGI:97530	Mouse	PMID:19056881
Biological Process	GO:0033327	Leydig cell differentiation	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:19056881
Biological Process	GO:0001553	luteinization	Plekha1	IGI	MGI:MGI:97530	Mouse	PMID:19056881
Biological Process	GO:0035264	multicellular organism growth	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:17143286
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PLEKHA1	IMP		Human	PMID:14516276
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PLEKHA1	IDA		Human	PMID:12101241
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:17143286
Biological Process	GO:0009791	post-embryonic development	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:17143286
Biological Process	GO:0060021	roof of mouth development	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:17143286
Biological Process	GO:0031529	ruffle organization	PLEKHA1	IDA		Human	PMID:15485858
Biological Process	GO:0048705	skeletal system morphogenesis	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:17143286
Biological Process	GO:0007283	spermatogenesis	Plekha1	IMP	MGI:MGI:3526857	Mouse	PMID:19056881

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern