Plekha1
Gene Detail

Symbol Name ID

Plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 MGI:2442213

Synonyms

C920009D07Rik, TAPP1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

73.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:130865756-130913312 bp, + strand From VEGA annotation of GRCm38   47557 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Plekha1

Human homologs

Human Homolog		PLEKHA1, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
NCBI Gene ID		59338
neXtProt AC		NX_Q9HB21
Human Synonyms		TAPP1
Human Chr (Location)		10q26.13; chr10:124134094-124191871 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLEKHA1

Alleles and phenotypes

All alleles(77) : Targeted(2) Gene trapped(75)
 

Mcie homozygous for a gene trapped allele exhibit postnatal lethality and increased body weight.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	androgen metabolic process, B cell receptor signaling pathway, ...
Component	cytoplasm, membrane, ...
Function	lipid binding, PDZ domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (146)    Tissues (26)    Images (30)
Theiler Stages: 11, 12, 13, 14, 23

Assay Type	Results
RNA in situ	146

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000029137 (Evidence)
Ensembl Gene Model	ENSMUSG00000040268 (Evidence)
Entrez Gene	101476 (Evidence)
DFCI	TC1578694, TC1580233, TC1585669, TC1589929, TC1601849
DoTS	DT.101263871, DT.110996153, DT.40162853, DT.491817
NIA Mouse Gene Index	U008848
Consensus CDS Project	CCDS21907.1
International Mouse Knockout Project Status	Plekha1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029137	VEGA Gene Model | MGI Sequence Detail	47557	C57BL/6J
transcript	OTTMUST00000072263	VEGA | MGI Sequence Detail	2301	Not Applicable
polypeptide	OTTMUSP00000037143	VEGA | MGI Sequence Detail	383	Not Applicable

All sequences(63) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(197 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000012853	pleckstriny domain-containing family A member 1

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:188003 Landego I, et al., Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. Eur J Immunol. 2012 Oct;42(10):2760-70
All references(39)

Other accession IDs

MGI:2141852