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Plekha1
Gene Detail
Symbol

Name
ID
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
MGI:2442213
Synonyms
C920009D07Rik, TAPP1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
73.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:130865756-130913312 bp, + strand
From VEGA annotation of GRCm38

  47557 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plekha1

Human
homologs
Human Homolog PLEKHA1, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
NCBI Gene ID 59338
neXtProt AC  NX_Q9HB21
Human Synonyms  TAPP1
Human Chr (Location)  10q26.13; chr10:122374578-122432355 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLEKHA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(79) : Gene trapped(75) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mcie homozygous for a gene trapped allele exhibit postnatal lethality and increased body weight.
 
Interactions
Plekha1 interacts with 344 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process androgen metabolic process, B cell receptor signaling pathway, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function lipid binding, PDZ domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (182)    Tissues (62)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 182
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000029137 (Evidence)
Ensembl Gene ModelENSMUSG00000040268 (Evidence)
Entrez Gene101476 (Evidence)
DFCITC1578694, TC1580233, TC1585669, TC1589929, TC1601849
DoTSDT.101263871, DT.110996153, DT.40162853, DT.491817
NIA Mouse Gene IndexU008848
Consensus CDS ProjectCCDS21907.1
International Mouse Knockout Project StatusPlekha1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029137 VEGA Gene Model | MGI Sequence Detail 47557 C57BL/6J ±  kb
transcript OTTMUST00000072263 VEGA | MGI Sequence Detail 2301 Not Applicable 
polypeptide OTTMUSP00000037143 VEGA | MGI Sequence Detail 383 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(30) UniProt(7)
Polymorphisms
SNPs within 2kb(210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012853 pleckstrin homology domain-containing family A member 1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:188003 Landego I, et al., Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. Eur J Immunol. 2012 Oct;42(10):2760-70
All references(40)
Other
accession IDs
MGI:2141852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory