Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLEC
  • Mouse genes Plec
  • Rat genes Plec
  • Zfish genes pleca,plecb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plec

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Plec	IDA		Mouse	PMID:10556294
Molecular Function	GO:0051015	actin filament binding	Plec	IDA		Mouse	PMID:9808630
Molecular Function	GO:0030506	ankyrin binding	PLEC	IPI	UniProtKB:O70511	Human	PMID:21223964
Molecular Function	GO:0030506	ankyrin binding	Plec	IPI	UniProtKB:O70511	Rat	PMID:21223964|RGD:8554309
Molecular Function	GO:0045296	cadherin binding	PLEC	HDA		Human	PMID:25468996
Molecular Function	GO:0008092	cytoskeletal protein binding	Plec	IDA		Rat	PMID:12095991|RGD:729534
Molecular Function	GO:0002162	dystroglycan binding	Plec	IDA		Mouse	PMID:23836526
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:Q9UMD9	Human	PMID:12482924
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:O14656	Human	PMID:18827015
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:P16144	Human	PMID:19242489
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:Q03001	Human	PMID:19932097
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:Q03001-1	Human	PMID:19932097
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:P35637	Human	PMID:22240165
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:P02533|UniProtKB:P04264|UniProtKB:P05783|UniProtKB:P05787|UniProtKB:P08670|UniProtKB:P13645|UniProtKB:P13647|UniProtKB:P17661|UniProtKB:P19012	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:P42858	Human	PMID:25959826
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PLEC	IPI	UniProtKB:Q14145	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:P02535|UniProtKB:P04104|UniProtKB:P05784|UniProtKB:P11679|UniProtKB:P20152|UniProtKB:P31001|UniProtKB:Q61414|UniProtKB:Q61781|UniProtKB:Q922U2	Mouse	MGI:MGI:7260090|PMID:24940650
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:P35486|UniProtKB:Q9D2G2	Mouse	MGI:MGI:6189615|PMID:29128334
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:P16144	Mouse	MGI:MGI:5926858|PMID:25703379
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:Q9ER39	Mouse	MGI:MGI:3814961|PMID:18827015
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:P20152	Mouse	PMID:15128297
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:E9Q6R7	Mouse	PMID:17389230
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:P70451	Mouse	PMID:12200133
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:O54950	Mouse	PMID:16608880
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:Q91ZU6	Mouse	PMID:19932097
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:P11531	Mouse	PMID:17389230
Molecular Function	GO:0005515	protein binding	Plec	IPI	UniProtKB:Q62165	Mouse	PMID:17389230
Molecular Function	GO:0005515	protein binding	Plec	IPI	RGD:1314799	Rat	PMID:12200133|RGD:729631
Molecular Function	GO:0043621	protein self-association	Plec	IDA		Mouse	PMID:22144912
Molecular Function	GO:0003723	RNA binding	PLEC	HDA		Human	PMID:22658674
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Plec	IMP		Rat	PMID:12095991|RGD:729534
Cellular Component	GO:0016324	apical plasma membrane	Plec	IDA		Rat	PMID:12389737|RGD:1599914
Cellular Component	GO:0030424	axon	Plec	IDA		Mouse	PMID:19625254
Cellular Component	GO:0009925	basal plasma membrane	Plec	IDA		Rat	PMID:12389737|RGD:1599914
Cellular Component	GO:0005903	brush border	Plec	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0071944	cell periphery	Plec	IDA		Mouse	PMID:9389647
Cellular Component	GO:0043292	contractile fiber	Plec	IDA		Mouse	PMID:14627610
Cellular Component	GO:0005737	cytoplasm	Plec	IDA		Mouse	PMID:23836526
Cellular Component	GO:0005829	cytosol	PLEC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Plec	IDA		Mouse	PMID:19625254
Cellular Component	GO:0070062	extracellular exosome	PLEC	HDA		Human	PMID:19199708
Cellular Component	GO:0005925	focal adhesion	PLEC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	PLEC	HDA		Human	PMID:21423176
Cellular Component	GO:0030056	hemidesmosome	PLEC	IDA		Human	PMID:12482924
Cellular Component	GO:0030056	hemidesmosome	Plec	IDA		Mouse	PMID:22144912
Cellular Component	GO:0045111	intermediate filament cytoskeleton	PLEC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005741	mitochondrial outer membrane	Plec	IMP		Mouse	PMID:18541706
Cellular Component	GO:0043209	myelin sheath	Plec	IDA		Mouse	PMID:19625254
Cellular Component	GO:0030016	myofibril	Plec	IDA		Mouse	PMID:26019234
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Plec	IDA		Rat	PMID:8686756|RGD:1599918
Cellular Component	GO:0042383	sarcolemma	PLEC	IDA		Human	PMID:21109228
Cellular Component	GO:0042383	sarcolemma	Plec	IDA		Mouse	PMID:17389230
Cellular Component	GO:0042383	sarcolemma	Plec	IDA		Rat	PMID:11482454|RGD:1599917
Cellular Component	GO:0042383	sarcolemma	Plec	IDA		Rat	PMID:21223964|RGD:8554309
Cellular Component	GO:0016528	sarcoplasm	Plec	IDA		Rat	PMID:21223964|RGD:8554309
Cellular Component	GO:0030018	Z disc	Plec	IDA		Mouse	PMID:17389230
Biological Process	GO:0030036	actin cytoskeleton organization	Plec	IMP		Mouse	PMID:9808630
Biological Process	GO:0030036	actin cytoskeleton organization	Plec	IMP	MGI:MGI:3613062	Mouse	PMID:16344482
Biological Process	GO:0007015	actin filament organization	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26519478
Biological Process	GO:2000689	actomyosin contractile ring assembly actin filament organization	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26519478
Biological Process	GO:0034332	adherens junction organization	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26519478
Biological Process	GO:0055013	cardiac muscle cell development	Plec	IMP	MGI:MGI:2181791	Mouse	PMID:9389647
Biological Process	GO:0000902	cell morphogenesis	Plec	IMP		Mouse	PMID:9808630
Biological Process	GO:0048870	cell motility	Plec	IMP		Mouse	PMID:9808630
Biological Process	GO:0031668	cellular response to extracellular stimulus	Plec	IMP		Mouse	PMID:9808630
Biological Process	GO:0071498	cellular response to fluid shear stress	Plec	IMP		Mouse	PMID:9808630
Biological Process	GO:0071464	cellular response to hydrostatic pressure	Plec	IMP		Mouse	PMID:25447312
Biological Process	GO:0071260	cellular response to mechanical stimulus	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26519478
Biological Process	GO:0030855	epithelial cell differentiation	Plec	IEP		Rat	PMID:8686756|RGD:1599918
Biological Process	GO:0061436	establishment of skin barrier	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:17606998
Biological Process	GO:0007565	female pregnancy	Plec	IEP		Rat	PMID:12389737|RGD:1599914
Biological Process	GO:0010761	fibroblast migration	Plec	IMP	MGI:MGI:3613062	Mouse	PMID:16344482
Biological Process	GO:0010467	gene expression	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:19932097
Biological Process	GO:0010467	gene expression	Plec	IMP		Mouse	PMID:24487589
Biological Process	GO:0031581	hemidesmosome assembly	PLEC	IDA		Human	PMID:12482924
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:23836526
Biological Process	GO:0045109	intermediate filament organization	Plec	IMP		Mouse	PMID:24487589
Biological Process	GO:0045109	intermediate filament organization	Plec	IMP		Mouse	PMID:18541706
Biological Process	GO:0045109	intermediate filament organization	Plec	IMP	MGI:MGI:3799314	Mouse	PMID:18490514
Biological Process	GO:0045109	intermediate filament organization	Plec	IMP	MGI:MGI:3799315	Mouse	PMID:26487297
Biological Process	GO:0045109	intermediate filament organization	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26519478
Biological Process	GO:0003334	keratinocyte development	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:17606998
Biological Process	GO:0030216	keratinocyte differentiation	Plec	IMP		Mouse	PMID:25447312
Biological Process	GO:0002522	leukocyte migration involved in immune response	Plec	IMP	MGI:MGI:3613062	Mouse	PMID:16344482
Biological Process	GO:0007626	locomotory behavior	pleca	IMP	ZFIN:ZDB-MRPHLNO-150622-8	Zfish	PMID:25866181
Biological Process	GO:0007626	locomotory behavior	plecb	IMP	ZFIN:ZDB-MRPHLNO-150622-9	Zfish	PMID:25866181
Biological Process	GO:0070584	mitochondrion morphogenesis	Plec	IMP		Mouse	PMID:18541706
Biological Process	GO:0007005	mitochondrion organization	Plec	IMP		Mouse	PMID:18541706
Biological Process	GO:0007005	mitochondrion organization	Plec	IMP	MGI:MGI:3799315	Mouse	PMID:18490514
Biological Process	GO:0035264	multicellular organism growth	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:17606998
Biological Process	GO:0022011	myelination in peripheral nervous system	Plec	IMP	MGI:MGI:4414774	Mouse	PMID:19625254
Biological Process	GO:0022011	myelination in peripheral nervous system	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:19625254
Biological Process	GO:0045445	myoblast differentiation	Plec	IMP		Mouse	PMID:25447312
Biological Process	GO:0030239	myofibril assembly	plecb	IMP	ZFIN:ZDB-MRPHLNO-150622-9	Zfish	PMID:25866181
Biological Process	GO:0006469	negative regulation of protein kinase activity	Plec	IMP		Mouse	PMID:12200133
Biological Process	GO:0006997	nucleus organization	Plec	IMP	MGI:MGI:3799315	Mouse	PMID:26487297
Biological Process	GO:0032287	peripheral nervous system myelin maintenance	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:23836526
Biological Process	GO:0008104	protein localization	Plec	IMP		Mouse	PMID:16608880
Biological Process	GO:0043933	protein-containing complex organization	Plec	IMP		Mouse	PMID:16608880
Biological Process	GO:2000983	regulation of ATP citrate synthase activity	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26019234
Biological Process	GO:0043114	regulation of vascular permeability	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26519478
Biological Process	GO:0022904	respiratory electron transport chain	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26019234
Biological Process	GO:0032094	response to food	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:17606998
Biological Process	GO:0007584	response to nutrient	Plec	IDA		Rat	PMID:12095991|RGD:729534
Biological Process	GO:0045214	sarcomere organization	Plec	IMP		Mouse	PMID:24487589
Biological Process	GO:0048741	skeletal muscle fiber development	Plec	IMP		Mouse	PMID:24487589
Biological Process	GO:0048741	skeletal muscle fiber development	Plec	IMP	MGI:MGI:3799315	Mouse	PMID:18490514
Biological Process	GO:0007519	skeletal muscle tissue development	Plec	IMP	MGI:MGI:2181791	Mouse	PMID:9389647
Biological Process	GO:0007519	skeletal muscle tissue development	pleca	IMP	ZFIN:ZDB-MRPHLNO-150622-8	Zfish	PMID:25866181
Biological Process	GO:0007519	skeletal muscle tissue development	plecb	IMP	ZFIN:ZDB-MRPHLNO-150622-9	Zfish	PMID:25866181
Biological Process	GO:0014866	skeletal myofibril assembly	Plec	IMP		Mouse	PMID:24487589
Biological Process	GO:0043588	skin development	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:17606998
Biological Process	GO:0043588	skin development	Plec	IMP	MGI:MGI:2181791	Mouse	PMID:9389647
Biological Process	GO:0010818	T cell chemotaxis	Plec	IMP	MGI:MGI:3613062	Mouse	PMID:16344482
Biological Process	GO:0120193	tight junction organization	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:26519478
Biological Process	GO:0019226	transmission of nerve impulse	Plec	IMP	MGI:MGI:3721885	Mouse	PMID:19625254
Biological Process	GO:0019226	transmission of nerve impulse	Plec	IMP	MGI:MGI:4414774	Mouse	PMID:19625254

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern