Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PKLR
  • Mouse genes Pklr
  • Rat genes Pklr
  • Zfish genes pklr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pklr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048029	monosaccharide binding	Pklr	IPI	CHEBI:78682	Rat	PMID:6742850|RGD:152176660
Molecular Function	GO:0005515	protein binding	PKLR	IPI	UniProtKB:Q9UBL6-2	Human	PMID:32296183
Molecular Function	GO:0004743	pyruvate kinase activity	Pklr	IDA		Mouse	PMID:7295297
Molecular Function	GO:0004743	pyruvate kinase activity	Pklr	IDA		Mouse	PMID:15155459
Molecular Function	GO:0004743	pyruvate kinase activity	Pklr	IDA		Rat	PMID:18062843|RGD:2317315
Molecular Function	GO:0004743	pyruvate kinase activity	Pklr	IDA		Rat	PMID:1834654|RGD:1599371
Molecular Function	GO:0004743	pyruvate kinase activity	Pklr	IDA		Rat	PMID:4273555|RGD:2302790
Molecular Function	GO:0004743	pyruvate kinase activity	Pklr	IDA		Rat	PMID:4353083|RGD:2302851
Molecular Function	GO:0004743	pyruvate kinase activity	Pklr	IDA		Rat	PMID:5492954|RGD:2302789
Cellular Component	GO:0005737	cytoplasm	Pklr	IDA		Mouse	PMID:18698006
Cellular Component	GO:0005829	cytosol	Pklr	IDA		Mouse	PMID:30150719
Cellular Component	GO:0005829	cytosol	Pklr	IDA		Rat	PMID:1834654|RGD:1599371
Cellular Component	GO:0070062	extracellular exosome	PKLR	HDA		Human	PMID:19056867
Cellular Component	GO:0005886	plasma membrane	Pklr	IDA		Mouse	PMID:18698006
Biological Process	GO:0006754	ATP biosynthetic process	Pklr	IDA		Rat	PMID:4273555|RGD:2302790
Biological Process	GO:0006754	ATP biosynthetic process	Pklr	IDA		Rat	PMID:5492954|RGD:2302789
Biological Process	GO:0005975	carbohydrate metabolic process	Pklr	IDA		Rat	PMID:1834654|RGD:1599371
Biological Process	GO:0071872	cellular response to epinephrine stimulus	Pklr	IEP		Rat	PMID:10620345|RGD:1625584
Biological Process	GO:0032869	cellular response to insulin stimulus	Pklr	IDA		Rat	PMID:9395079|RGD:1625596
Biological Process	GO:0006096	glycolytic process	Pklr	IDA		Mouse	PMID:7295297
Biological Process	GO:0006096	glycolytic process	Pklr	IDA		Rat	PMID:4273555|RGD:2302790
Biological Process	GO:0006096	glycolytic process	Pklr	IDA		Rat	PMID:4353083|RGD:2302851
Biological Process	GO:0001889	liver development	pklr	IMP	ZFIN:ZDB-MRPHLNO-131120-7	Zfish	PMID:23813869
Biological Process	GO:0042866	pyruvate biosynthetic process	Pklr	IDA		Rat	PMID:4273555|RGD:2302790
Biological Process	GO:0042866	pyruvate biosynthetic process	Pklr	IDA		Rat	PMID:5492954|RGD:2302789
Biological Process	GO:0033198	response to ATP	Pklr	IDA		Rat	PMID:11104754|RGD:1625594
Biological Process	GO:0051591	response to cAMP	Pklr	IDA		Rat	PMID:9395079|RGD:1625596
Biological Process	GO:0009749	response to glucose	Pklr	IEP		Rat	PMID:16644726|RGD:1625590
Biological Process	GO:0009408	response to heat	Pklr	IDA		Rat	PMID:12417155|RGD:1625591
Biological Process	GO:0001666	response to hypoxia	Pklr	IEP		Rat	PMID:11356723|RGD:68728
Biological Process	GO:0010226	response to lithium ion	Pklr	IDA		Rat	PMID:10700396|RGD:1625595
Biological Process	GO:0010038	response to metal ion	Pklr	IEP		Rat	PMID:11357483|RGD:1625593
Biological Process	GO:0007584	response to nutrient	Pklr	IEP		Rat	PMID:11368649|RGD:1625592
Biological Process	GO:0051707	response to other organism	Pklr	IMP	MGI:MGI:3027066	Mouse	PMID:14595440

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern